ENCODE cCRE Registry (SCREEN)
The ENCODE Registry of candidate cis-Regulatory Elements (cCREs) is a curated annotation of regulatory regions in the human and mouse genomes derived from ENCODE and Roadmap Epigenomics data. Each cCRE is classified by its biochemical signature, including promoter-like, enhancer-like, and CTCF-bound elements based on DNase hypersensitivity, H3K4me3, H3K27ac, and CTCF ChIP-seq signals. The registry is explorable through the SCREEN (Search Candidate cis-Regulatory Elements by ENCODE) web portal, which lets users browse cCREs and their activity across cell types and tissues. cCREs/SCREEN are produced as part of the ENCODE project and serve as an upstream source for downstream resources such as GenomicKB.
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