PRS Atlas
The PRS Atlas is a comprehensive resource analyzing 162 polygenic risk scores (PRS) derived from genome-wide association studies against 551 heritable traits from the UK Biobank study (N=334,398). The atlas was developed to highlight putative causal relationships across the human phenome using Mendelian randomization approaches. PRS were constructed using independent SNPs (p<5×10⁻⁵) to evaluate associations with complex traits, providing insights into disease susceptibility and potential causal risk factors. The resource includes a web application for querying and visualizing associations between genetic liability and diverse health outcomes.
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