Project Achilles
Project Achilles is a systematic effort aimed at identifying and cataloging gene essentiality across hundreds of genomically characterized cancer cell lines. Achilles uses genome-scale RNAi and CRISPR-Cas9 genetic perturbation reagents to silence or knockout individual genes and identify those genes that affect cell survival.
[{"category": "Organization", "contact_details": [{"contact_type": "email", "value": "achilles@broadinstitute.org"}, {"contact_type": "url", "value": "https://depmap.org/portal/achilles/"}], "id": "broad", "label": "Project Achilles, Broad Institute"}]
[{"category": "Product", "description": "Network embeddings of the Bioteque graph that represent biological entities and their associations", "id": "bioteque.embeddings", "name": "Bioteque Embeddings", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "achilles"}, {"relation_type": "prov:hadPrimarySource", "source": "bioteque"}, {"relation_type": "prov:hadPrimarySource", "source": "bto"}, {"relation_type": "prov:hadPrimarySource", "source": "ccle"}, {"relation_type": "prov:hadPrimarySource", "source": "cellosaurus"}, {"relation_type": "prov:hadPrimarySource", "source": "chebi"}, {"relation_type": "prov:hadPrimarySource", "source": "chemicalchecker"}, {"relation_type": "prov:hadPrimarySource", "source": "clue"}, {"relation_type": "prov:hadPrimarySource", "source": "compartments"}, {"relation_type": "prov:hadPrimarySource", "source": "corum"}, {"relation_type": "prov:hadPrimarySource", "source": "cosmic"}, {"relation_type": "prov:hadPrimarySource", "source": "creeds"}, {"relation_type": "prov:hadPrimarySource", "source": "ctd"}, {"relation_type": "prov:hadPrimarySource", "source": "depmap"}, {"relation_type": "prov:hadPrimarySource", "source": "disgenet"}, {"relation_type": "prov:hadPrimarySource", "source": "dorothea"}, {"relation_type": "prov:hadPrimarySource", "source": "drugbank"}, {"relation_type": "prov:hadPrimarySource", "source": "drugcentral"}, {"relation_type": "prov:hadPrimarySource", "source": "gdsc"}, {"relation_type": "prov:hadPrimarySource", "source": "go"}, {"relation_type": "prov:hadPrimarySource", "source": "gtex"}, {"relation_type": "prov:hadPrimarySource", "source": "hpa"}, {"relation_type": "prov:hadPrimarySource", "source": "huri"}, {"relation_type": "prov:hadPrimarySource", "source": "intact"}, {"relation_type": "prov:hadPrimarySource", "source": "interpro"}, {"relation_type": "prov:hadPrimarySource", "source": "lincs"}, {"relation_type": "prov:hadPrimarySource", "source": "offsides"}, {"relation_type": "prov:hadPrimarySource", "source": "omnipath"}, {"relation_type": "prov:hadPrimarySource", "source": "opentargets"}, {"relation_type": "prov:hadPrimarySource", "source": "pharmacodb"}, {"relation_type": "prov:hadPrimarySource", "source": "prism"}, {"relation_type": "prov:hadPrimarySource", "source": "progeny"}, {"relation_type": "prov:hadPrimarySource", "source": "reactome"}, {"relation_type": "prov:hadPrimarySource", "source": "repodb"}, {"relation_type": "prov:hadPrimarySource", "source": "repohub"}, {"relation_type": "prov:hadPrimarySource", "source": "sider"}, {"relation_type": "prov:hadPrimarySource", "source": "string"}, {"relation_type": "prov:hadPrimarySource", "source": "tissues"}], "product_url": "https://bioteque.irbbarcelona.org/downloads/embeddings"}]
{"activity_status": "active", "category": "DataSource", "contacts": [{"category": "Organization", "contact_details": [{"contact_type": "email", "value": "achilles@broadinstitute.org"}, {"contact_type": "url", "value": "https://depmap.org/portal/achilles/"}], "id": "broad", "label": "Project Achilles, Broad Institute"}], "creation_date": "2025-07-08T00:00:00Z", "curators": [{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://depmap.org/"}], "label": "DepMap"}], "description": "Project Achilles is a systematic effort aimed at identifying and cataloging gene essentiality across hundreds of genomically characterized cancer cell lines. Achilles uses genome-scale RNAi and CRISPR-Cas9 genetic perturbation reagents to silence or knockout individual genes and identify those genes that affect cell survival.", "domains": ["biomedical", "genomics", "health"], "homepage_url": "https://depmap.org/portal/achilles/", "id": "achilles", "last_modified_date": "2025-12-13T00:00:00Z", "layout": "resource_detail", "license": {"id": "https://depmap.org/portal/terms/", "label": "DepMap Terms of Use"}, "name": "Project Achilles", "products": [{"category": "Product", "description": "Network embeddings of the Bioteque graph that represent biological entities and their associations", "id": "bioteque.embeddings", "name": "Bioteque Embeddings", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "achilles"}, {"relation_type": "prov:hadPrimarySource", "source": "bioteque"}, {"relation_type": "prov:hadPrimarySource", "source": "bto"}, {"relation_type": "prov:hadPrimarySource", "source": "ccle"}, {"relation_type": "prov:hadPrimarySource", "source": "cellosaurus"}, {"relation_type": "prov:hadPrimarySource", "source": "chebi"}, {"relation_type": "prov:hadPrimarySource", "source": "chemicalchecker"}, {"relation_type": "prov:hadPrimarySource", "source": "clue"}, {"relation_type": "prov:hadPrimarySource", "source": "compartments"}, {"relation_type": "prov:hadPrimarySource", "source": "corum"}, {"relation_type": "prov:hadPrimarySource", "source": "cosmic"}, {"relation_type": "prov:hadPrimarySource", "source": "creeds"}, {"relation_type": "prov:hadPrimarySource", "source": "ctd"}, {"relation_type": "prov:hadPrimarySource", "source": "depmap"}, {"relation_type": "prov:hadPrimarySource", "source": "disgenet"}, {"relation_type": "prov:hadPrimarySource", "source": "dorothea"}, {"relation_type": "prov:hadPrimarySource", "source": "drugbank"}, {"relation_type": "prov:hadPrimarySource", "source": "drugcentral"}, {"relation_type": "prov:hadPrimarySource", "source": "gdsc"}, {"relation_type": "prov:hadPrimarySource", "source": "go"}, {"relation_type": "prov:hadPrimarySource", "source": "gtex"}, {"relation_type": "prov:hadPrimarySource", "source": "hpa"}, {"relation_type": "prov:hadPrimarySource", "source": "huri"}, {"relation_type": "prov:hadPrimarySource", "source": "intact"}, {"relation_type": "prov:hadPrimarySource", "source": "interpro"}, {"relation_type": "prov:hadPrimarySource", "source": "lincs"}, {"relation_type": "prov:hadPrimarySource", "source": "offsides"}, {"relation_type": "prov:hadPrimarySource", "source": "omnipath"}, {"relation_type": "prov:hadPrimarySource", "source": "opentargets"}, {"relation_type": "prov:hadPrimarySource", "source": "pharmacodb"}, {"relation_type": "prov:hadPrimarySource", "source": "prism"}, {"relation_type": "prov:hadPrimarySource", "source": "progeny"}, {"relation_type": "prov:hadPrimarySource", "source": "reactome"}, {"relation_type": "prov:hadPrimarySource", "source": "repodb"}, {"relation_type": "prov:hadPrimarySource", "source": "repohub"}, {"relation_type": "prov:hadPrimarySource", "source": "sider"}, {"relation_type": "prov:hadPrimarySource", "source": "string"}, {"relation_type": "prov:hadPrimarySource", "source": "tissues"}], "product_url": "https://bioteque.irbbarcelona.org/downloads/embeddings"}], "publications": [{"authors": ["Tsherniak A", "Vazquez F", "Montgomery PG", "Weir BA", "Kryukov G", "Cowley GS"], "doi": "10.1016/j.cell.2017.06.010", "id": "doi:10.1016/j.cell.2017.06.010", "journal": "Cell", "title": "Defining a Cancer Dependency Map", "year": "2017"}], "taxon": ["NCBITaxon:9606"]}