name: FDA Global Substance Registration System (UNII)
description: FDA's Global Substance Registration System (GSRS) is a comprehensive database that provides Unique Ingredient Identifiers (UNIIs) for substances in FDA-regulated products. UNIIs uniquely define substances based on scientific identity characteristics using ISO 11238 data elements, enabling efficient and accurate exchange of substance information across regulatory domains.
contacts: [{"category": "Organization", "contact_details": [{"contact_type": "email", "value": "FDA-SRS@fda.hhs.gov"}], "label": "FDA Substance Registration System Team"}]
products: [{"category": "GraphicalInterface", "description": "Web-based search interface for finding substances by UNII, name, or other identifiers", "format": "http", "id": "unii.search", "name": "UNII Search Service", "product_url": "https://precision.fda.gov/uniisearch"}, {"category": "Product", "compression": "zip", "description": "Downloadable list of all UNIIs with basic substance information", "format": "csv", "id": "unii.list", "name": "UNII List Download", "product_url": "https://precision.fda.gov/uniisearch/archive/latest/UNIIs.zip", "warnings": ["File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29: HTTP 403 error when accessing file"]}, {"category": "Product", "compression": "zip", "description": "Comprehensive UNII data with detailed substance attributes and mappings", "format": "mixed", "id": "unii.data", "name": "UNII Data Download", "product_url": "https://precision.fda.gov/uniisearch/archive/latest/UNII_Data.zip", "warnings": ["File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29: HTTP 403 error when accessing file"]}, {"category": "Product", "description": "Legacy UNII identifiers for historical substances", "format": "txt", "id": "unii.legacy", "name": "Legacy UNIIs", "product_url": "https://precision.fda.gov/uniisearch/archive/latest/Legacy_UNIIs.txt", "warnings": ["File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29: HTTP 403 error when accessing file"]}, {"description": "The MechRepoNet knowledge graph in its original format", "id": "mechreponet.kg", "name": "MechRepoNet Knowledge Graph", "original_source": ["ctd", "do", "go", "chebi", "reactome", "interpro", "hp", "cl", "pr", "uberon", "ncbitaxon", "hetionet", "complexportal", "rnacentral", "mirtarbase", "unii", "biolink"], "product_url": "https://github.com/SuLab/MechRepoNet/releases/tag/publication", "secondary_source": ["mechreponet"]}]
raw_data: {"activity_status": "active", "category": "DataSource", "contacts": [{"category": "Organization", "contact_details": [{"contact_type": "email", "value": "FDA-SRS@fda.hhs.gov"}], "label": "FDA Substance Registration System Team"}], "creation_date": "2025-07-17T00:00:00Z", "description": "FDA's Global Substance Registration System (GSRS) is a comprehensive database that provides Unique Ingredient Identifiers (UNIIs) for substances in FDA-regulated products. UNIIs uniquely define substances based on scientific identity characteristics using ISO 11238 data elements, enabling efficient and accurate exchange of substance information across regulatory domains.", "domains": ["clinical", "drug discovery", "pharmacology", "public health"], "homepage_url": "https://precision.fda.gov/uniisearch", "id": "unii", "last_modified_date": "2025-09-24T00:00:00Z", "layout": "resource_detail", "name": "FDA Global Substance Registration System (UNII)", "products": [{"category": "GraphicalInterface", "description": "Web-based search interface for finding substances by UNII, name, or other identifiers", "format": "http", "id": "unii.search", "name": "UNII Search Service", "product_url": "https://precision.fda.gov/uniisearch"}, {"category": "Product", "compression": "zip", "description": "Downloadable list of all UNIIs with basic substance information", "format": "csv", "id": "unii.list", "name": "UNII List Download", "product_url": "https://precision.fda.gov/uniisearch/archive/latest/UNIIs.zip", "warnings": ["File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29: HTTP 403 error when accessing file"]}, {"category": "Product", "compression": "zip", "description": "Comprehensive UNII data with detailed substance attributes and mappings", "format": "mixed", "id": "unii.data", "name": "UNII Data Download", "product_url": "https://precision.fda.gov/uniisearch/archive/latest/UNII_Data.zip", "warnings": ["File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29: HTTP 403 error when accessing file"]}, {"category": "Product", "description": "Legacy UNII identifiers for historical substances", "format": "txt", "id": "unii.legacy", "name": "Legacy UNIIs", "product_url": "https://precision.fda.gov/uniisearch/archive/latest/Legacy_UNIIs.txt", "warnings": ["File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29_ HTTP 403 error when accessing file", "File was not able to be retrieved when checked on 2025-09-29: HTTP 403 error when accessing file"]}, {"description": "The MechRepoNet knowledge graph in its original format", "id": "mechreponet.kg", "name": "MechRepoNet Knowledge Graph", "original_source": ["ctd", "do", "go", "chebi", "reactome", "interpro", "hp", "cl", "pr", "uberon", "ncbitaxon", "hetionet", "complexportal", "rnacentral", "mirtarbase", "unii", "biolink"], "product_url": "https://github.com/SuLab/MechRepoNet/releases/tag/publication", "secondary_source": ["mechreponet"]}], "publications": [{"id": "https://www.fda.gov/science-research/fda-grand-rounds/fdas-global-substance-registration-system-gsrs-unique-ingredient-identifiers-uniis-uniquely-define", "title": "FDA Grand Rounds: FDA's Global Substance Registration System (GSRS) Unique Ingredient Identifiers (UNIIs)"}], "repository": "https://ginas.ncats.nih.gov/ginas/app"}