NHLBI Trans-Omics for Precision Medicine
The NHLBI Trans-Omics for Precision Medicine (TOPMed) program generates scientific resources to enhance understanding of fundamental biological processes that underlie heart, lung, blood, and sleep disorders, providing whole genome sequencing and multi-omics data from diverse populations.
[{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://www.nhlbi.nih.gov/"}], "label": "NHLBI (National Heart, Lung, and Blood Institute)"}]
[{"category": "GraphicalInterface", "description": "TOPMed program website for navigating cohorts, resources, and program documentation.", "format": "http", "id": "topmed.portal", "name": "TOPMed Portal", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "topmed"}], "product_url": "https://topmed.nhlbi.nih.gov/"}, {"category": "GraphicalInterface", "description": "TOPMed data access page with instructions and links for controlled-access data workflows.", "format": "http", "id": "topmed.data-access", "name": "TOPMed Data Access", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "topmed"}], "product_url": "https://topmed.nhlbi.nih.gov/data-resources/data-access"}, {"category": "DocumentationProduct", "description": "PDF summary table of whole-genome sequencing counts available in TOPMed.", "format": "pdf", "id": "topmed.wgs-counts", "name": "TOPMed WGS Counts PDF", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "topmed"}], "product_file_size": 442890, "product_url": "https://topmed.nhlbi.nih.gov/sites/default/files/documents/TOPMed%20WGS%20Counts%2020250505.pdf"}]
{"activity_status": "active", "category": "DataSource", "contacts": [{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://www.nhlbi.nih.gov/"}], "label": "NHLBI (National Heart, Lung, and Blood Institute)"}], "creation_date": "2025-10-30T00:00:00Z", "description": "The NHLBI Trans-Omics for Precision Medicine (TOPMed) program generates scientific resources to enhance understanding of fundamental biological processes that underlie heart, lung, blood, and sleep disorders, providing whole genome sequencing and multi-omics data from diverse populations.", "domains": ["genomics", "clinical", "precision medicine"], "homepage_url": "https://topmed.nhlbi.nih.gov/", "id": "topmed", "infores_id": "topmed", "last_modified_date": "2026-02-20T00:00:00Z", "layout": "resource_detail", "name": "NHLBI Trans-Omics for Precision Medicine", "products": [{"category": "GraphicalInterface", "description": "TOPMed program website for navigating cohorts, resources, and program documentation.", "format": "http", "id": "topmed.portal", "name": "TOPMed Portal", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "topmed"}], "product_url": "https://topmed.nhlbi.nih.gov/"}, {"category": "GraphicalInterface", "description": "TOPMed data access page with instructions and links for controlled-access data workflows.", "format": "http", "id": "topmed.data-access", "name": "TOPMed Data Access", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "topmed"}], "product_url": "https://topmed.nhlbi.nih.gov/data-resources/data-access"}, {"category": "DocumentationProduct", "description": "PDF summary table of whole-genome sequencing counts available in TOPMed.", "format": "pdf", "id": "topmed.wgs-counts", "name": "TOPMed WGS Counts PDF", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "topmed"}], "product_file_size": 442890, "product_url": "https://topmed.nhlbi.nih.gov/sites/default/files/documents/TOPMed%20WGS%20Counts%2020250505.pdf"}], "publications": [{"authors": ["Daniel Taliun", "Daniel N. Harris", "Michael D. Kessler", "Jedidiah Carlson", "Zachary A. Szpiech", "Raul Torres", "Sarah A. Gagliano Taliun", "Andr\u00e9 Corvelo", "Stephanie M. Gogarten", "Hyun Min Kang", "Achilleas N. Pitsillides", "Jonathon LeFaive", "Seung-been Lee", "Xiaowen Tian", "Brian L. Browning", "Sayantan Das", "Anne-Katrin Emde", "Wayne E. Clarke", "Douglas P. Loesch", "Amol C. Shetty", "Thomas W. Blackwell", "Albert V. Smith", "Quenna Wong", "Xiaoming Liu", "Matthew P. Conomos", "Dean M. Bobo", "Fran\u00e7ois Aguet", "Christine Albert", "Alvaro Alonso", "Kristin G. Ardlie", "Dan E. Arking", "Stella Aslibekyan", "Paul L. Auer", "John Barnard", "R. Graham Barr", "Lucas Barwick", "Lewis C. Becker", "Rebecca L. Beer", "Emelia J. Benjamin", "Lawrence F. Bielak", "John Blangero", "Michael Boehnke", "Donald W. Bowden", "Jennifer A. Brody", "Esteban G. Burchard", "Brian E. Cade", "James F. Casella", "Brandon Chalazan", "Daniel I. Chasman", "Yii-Der Ida Chen", "Michael H. Cho", "Seung Hoan Choi", "Mina K. Chung", "Clary B. Clish", "Adolfo Correa", "Joanne E. Curran", "Brian Custer", "Dawood Darbar", "Michelle Daya", "Mariza de Andrade", "Dawn L. DeMeo", "Susan K. Dutcher", "Patrick T. Ellinor", "Leslie S. Emery", "Celeste Eng", "Diane Fatkin", "Tasha Fingerlin", "Lukas Forer", "Myriam Fornage", "Nora Franceschini", "Christian Fuchsberger", "Stephanie M. Fullerton", "Soren Germer", "Mark T. Gladwin", "Daniel J. Gottlieb", "Xiuqing Guo", "Michael E. Hall", "Jiang He", "Nancy L. Heard-Costa", "Susan R. Heckbert", "Marguerite R. Irvin", "Jill M. Johnsen", "Andrew D. Johnson", "Robert Kaplan", "Sharon L. R. Kardia", "Tanika Kelly", "Shannon Kelly", "Eimear E. Kenny", "Douglas P. Kiel", "Robert Klemmer", "Barbara A. Konkle", "Charles Kooperberg", "Anna K\u00f6ttgen", "Leslie A. Lange", "Jessica Lasky-Su", "Daniel Levy", "Xihong Lin", "Keng-Han Lin", "Chunyu Liu", "Ruth J. F. Loos", "Lori Garman", "Robert Gerszten", "Steven A. Lubitz", "Kathryn L. Lunetta", "Angel C. Y. Mak", "Ani Manichaikul", "Alisa K. Manning", "Rasika A. Mathias", "David D. McManus", "Stephen T. McGarvey", "James B. Meigs", "Deborah A. Meyers", "Julie L. Mikulla", "Mollie A. Minear", "Braxton D. Mitchell", "Sanghamitra Mohanty", "May E. Montasser", "Courtney Montgomery", "Alanna C. Morrison", "Joanne M. Murabito", "Andrea Natale", "Pradeep Natarajan", "Sarah C. Nelson", "Kari E. North", "Jeffrey R. O\u2019Connell", "Nicholette D. Palmer", "Nathan Pankratz", "Gina M. Peloso", "Patricia A. Peyser", "Jacob Pleiness", "Wendy S. Post", "Bruce M. Psaty", "D. C. Rao", "Susan Redline", "Alexander P. Reiner", "Dan Roden", "Jerome I. Rotter", "Ingo Ruczinski", "Chlo\u00e9 Sarnowski", "Sebastian Schoenherr", "David A. Schwartz", "Jeong-Sun Seo", "Sudha Seshadri", "Vivien A. Sheehan", "Wayne H. Sheu", "M. Benjamin Shoemaker", "Nicholas L. Smith", "Jennifer A. Smith", "Nona Sotoodehnia", "Adrienne M. Stilp", "Weihong Tang", "Kent D. Taylor", "Marilyn Telen", "Timothy A. Thornton", "Russell P. Tracy", "David J. Van Den Berg", "Ramachandran S. Vasan", "Karine A. Viaud-Martinez", "Scott Vrieze", "Daniel E. Weeks", "Bruce S. Weir", "Scott T. Weiss", "Lu-Chen Weng", "Cristen J. Willer", "Yingze Zhang", "Xutong Zhao", "Donna K. Arnett", "Allison E. Ashley-Koch", "Kathleen C. Barnes", "Eric Boerwinkle", "Stacey Gabriel", "Richard Gibbs", "Kenneth M. Rice", "Stephen S. Rich", "Edwin K. Silverman", "Pankaj Qasba", "Weiniu Gan", "Namiko Abe", "Laura Almasy", "Seth Ament", "Peter Anderson", "Pramod Anugu", "Deborah Applebaum-Bowden", "Tim Assimes", "Dimitrios Avramopoulos", "Emily Barron-Casella", "Terri Beaty", "Gerald Beck", "Diane Becker", "Amber Beitelshees", "Takis Benos", "Marcos Bezerra", "Joshua Bis", "Russell Bowler", "Ulrich Broeckel", "Jai Broome", "Karen Bunting", "Carlos Bustamante", "Erin Buth", "Jonathan Cardwell", "Vincent Carey", "Cara Carty", "Richard Casaburi", "Peter Castaldi", "Mark Chaffin", "Christy Chang", "Yi-Cheng Chang", "Sameer Chavan", "Bo-Juen Chen", "Wei-Min Chen", "Lee-Ming Chuang", "Ren-Hua Chung", "Suzy Comhair", "Elaine Cornell", "Carolyn Crandall", "James Crapo", "Jeffrey Curtis", "Coleen Damcott", "Sean David", "Colleen Davis", "Lisa de las Fuentes", "Michael DeBaun", "Ranjan Deka", "Scott Devine", "Qing Duan", "Ravi Duggirala", "Jon Peter Durda", "Charles Eaton", "Lynette Ekunwe", "Adel El Boueiz", "Serpil Erzurum", "Charles Farber", "Matthew Flickinger", "Myriam Fornage", "Chris Frazar", "Mao Fu", "Lucinda Fulton", "Shanshan Gao", "Yan Gao", "Margery Gass", "Bruce Gelb", "Xiaoqi Priscilla Geng", "Mark Geraci", "Auyon Ghosh", "Chris Gignoux", "David Glahn", "Da-Wei Gong", "Harald Goring", "Sharon Graw", "Daniel Grine", "C. Charles Gu", "Yue Guan", "Namrata Gupta", "Jeff Haessler", "Nicola L. Hawley", "Ben Heavner", "David Herrington", "Craig Hersh", "Bertha Hidalgo", "James Hixson", "Brian Hobbs", "John Hokanson", "Elliott Hong", "Karin Hoth", "Chao Agnes Hsiung", "Yi-Jen Hung", "Haley Huston", "Chii Min Hwu", "Rebecca Jackson", "Deepti Jain", "Min A. Jhun", "Craig Johnson", "Rich Johnston", "Kimberly Jones", "Sekar Kathiresan", "Alyna Khan", "Wonji Kim", "Greg Kinney", "Holly Kramer", "Christoph Lange", "Ethan Lange", "Leslie Lange", "Cecelia Laurie", "Meryl LeBoff", "Jiwon Lee", "Seunggeun Shawn Lee", "Wen-Jane Lee", "David Levine", "Joshua Lewis", "Xiaohui Li", "Yun Li", "Henry Lin", "Honghuang Lin", "Keng Han Lin", "Simin Liu", "Yongmei Liu", "Yu Liu", "James Luo", "Michael Mahaney", "Barry Make", "JoAnn Manson", "Lauren Margolin", "Lisa Martin", "Susan Mathai", "Susanne May", "Patrick McArdle", "Merry-Lynn McDonald", "Sean McFarland", "Daniel McGoldrick", "Caitlin McHugh", "Hao Mei", "Luisa Mestroni", "Nancy Min", "Ryan L. Minster", "Matt Moll", "Arden Moscati", "Solomon Musani", "Stanford Mwasongwe", "Josyf C. Mychaleckyj", "Girish Nadkarni", "Rakhi Naik", "Take Naseri", "Sergei Nekhai", "Bonnie Neltner", "Heather Ochs-Balcom", "David Paik", "James Pankow", "Afshin Parsa", "Juan Manuel Peralta", "Marco Perez", "James Perry", "Ulrike Peters", "Lawrence S. Phillips", "Toni Pollin", "Julia Powers Becker", "Meher Preethi Boorgula", "Michael Preuss", "Dandi Qiao", "Zhaohui Qin", "Nicholas Rafaels", "Laura Raffield", "Laura Rasmussen-Torvik", "Aakrosh Ratan", "Robert Reed", "Elizabeth Regan", "Muagututi\u2018a Sefuiva Reupena", "Carolina Roselli", "Pamela Russell", "Sarah Ruuska", "Kathleen Ryan", "Ester Cerdeira Sabino", "Danish Saleheen", "Shabnam Salimi", "Steven Salzberg", "Kevin Sandow", "Vijay G. Sankaran", "Christopher Scheller", "Ellen Schmidt", "Karen Schwander", "Frank Sciurba", "Christine Seidman", "Jonathan Seidman", "Stephanie L. Sherman", "Aniket Shetty", "Wayne Hui-Heng Sheu", "Brian Silver", "Josh Smith", "Tanja Smith", "Sylvia Smoller", "Beverly Snively", "Michael Snyder", "Tamar Sofer", "Garrett Storm", "Elizabeth Streeten", "Yun Ju Sung", "Jody Sylvia", "Adam Szpiro", "Carole Sztalryd", "Hua Tang", "Margaret Taub", "Matthew Taylor", "Simeon Taylor", "Machiko Threlkeld", "Lesley Tinker", "David Tirschwell", "Sarah Tishkoff", "Hemant Tiwari", "Catherine Tong", "Michael Tsai", "Dhananjay Vaidya", "Peter VandeHaar", "Tarik Walker", "Robert Wallace", "Avram Walts", "Fei Fei Wang", "Heming Wang", "Karol Watson", "Jennifer Wessel", "Kayleen Williams", "L. Keoki Williams", "Carla Wilson", "Joseph Wu", "Huichun Xu", "Lisa Yanek", "Ivana Yang", "Rongze Yang", "Norann Zaghloul", "Maryam Zekavat", "Snow Xueyan Zhao", "Wei Zhao", "Degui Zhi", "Xiang Zhou", "Xiaofeng Zhu", "George J. Papanicolaou", "Deborah A. Nickerson", "Sharon R. Browning", "Michael C. Zody", "Sebastian Z\u00f6llner", "James G. Wilson", "L. Adrienne Cupples", "Cathy C. Laurie", "Cashell E. Jaquish", "Ryan D. Hernandez", "Timothy D. O\u2019Connor", "Gon\u00e7alo R. Abecasis"], "doi": "10.1038/s41586-021-03205-y", "id": "doi:10.1038/s41586-021-03205-y", "journal": "Nature", "preferred": true, "title": "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program", "year": "2021"}], "synonyms": ["TOPMed", "Trans-Omics for Precision Medicine"], "taxon": ["NCBITaxon:9606"]}