PharmacoDB
PharmacoDB is a comprehensive integrative pharmacogenomics database that aggregates and standardizes large-scale cancer drug screening studies to enable systematic exploration and comparison of drug response phenotypes across diverse cancer cell line models. The database addresses critical challenges in pharmacogenomics research by harmonizing disparate datasets that historically used heterogeneous formats for drug sensitivity measurements and lacked standardized identifiers for cell lines and compounds. PharmacoDB integrates multiple major cancer pharmacogenomic datasets including the Cancer Cell Line Encyclopedia (CCLE), Genomics of Drug Sensitivity in Cancer (GDSC), Cancer Therapeutics Response Portal (CTRP), and others, assembling them into a unified queryable resource. The database contains dose-response data for over 56,000 compounds tested across approximately 1,758 cancer cell lines representing 30 different tissue types, with more than 6.3 million individual drug screening experiments profiling sensitivity measurements. Users can search across all integrated studies to identify instances where a specific compound or cell line has been characterized, visualize and compare dose-response curves for particular cell line-compound pairs from different datasets, and explore patterns of drug sensitivity across tissue types. PharmacoDB provides both a user-friendly web interface for interactive browsing and data visualization, as well as a RESTful JSON API for programmatic access enabling computational workflows and large-scale analyses. The database is designed to support biomarker discovery, drug repurposing investigations, and comparative pharmacogenomics studies by providing standardized access to otherwise fragmented cancer drug screening data.
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