Target Central Resource Database
The Target Central Resource Database (TCRD) is a comprehensive multi-omics knowledge base developed by the NIH Common Fund Illuminating the Druggable Genome (IDG) program to catalog and illuminate the human proteome, with special focus on understudied proteins in four major druggable protein families G-protein coupled receptors (GPCRs), nuclear receptors, ion channels, and protein kinases. TCRD aggregates data from over 80 diverse sources including protein-protein interactions, disease associations, drug-target relationships, gene expression profiles, tissue specificity, pathway memberships, phenotype associations, and pharmacological data to create a unified resource for target prioritization and drug discovery research. The database employs a protein Target Development Level (TDL) classification system (Tclin, Tchem, Tbio, Tdark) that ranks proteins based on the amount of available knowledge, specifically highlighting understudied dark proteins that lack adequate characterization. TCRD contains extensive information on protein sequences, structures, functions, disease relationships, and chemical interactions, integrating data from resources such as UniProt, ChEMBL, DrugCentral, STRING, GTEx, OMIM, and many others. The database is designed to be machine-learning ready with structured data formats suitable for computational analysis and target prediction algorithms. TCRD serves as the backend data infrastructure for Pharos, the user-friendly web interface that enables researchers to browse, visualize, and analyze the integrated target data through interactive tools and visualizations. The resource is continuously updated with new data sources and releases, with current version 6.13.5 containing comprehensive annotations for the human proteome.
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