AOP-Wiki
The AOP-Wiki is the primary collaborative authoring and curation interface for the Adverse Outcome Pathway Knowledge Base (AOP-KB). It enables the community to develop, review, browse, and export Adverse Outcome Pathways (AOPs) linking molecular initiating events through key events to adverse outcomes relevant to human and ecological risk assessment. Structured exports (XML and tabular subsets) support computational toxicology, ontology mapping, and integration into predictive assessment workflows.
[{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://aopwiki.org/info_pages/10"}], "label": "AOP-Wiki Coordination Group"}]
[{"category": "GraphicalInterface", "description": "Web portal for browsing, authoring, and reviewing AOPs, key events (KEs), key event relationships (KERs), stressors, and supporting documentation", "format": "http", "id": "aop-wiki.portal", "name": "AOP-Wiki Portal", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://aopwiki.org/"}, {"category": "ProgrammingInterface", "connection_url": "https://aopwiki-rdf.prod.openrisknet.org/", "description": "OpenRiskNet SPARQL endpoint loaded with RDF converted from AOP-Wiki quarterly XML dumps for querying AOPs, key events, key event relationships, and stressors.", "format": "http", "id": "aop-wiki.sparql", "is_public": true, "name": "AOP-Wiki SPARQL Endpoint", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://openrisknet.org/e-infrastructure/services/133/"}, {"category": "Product", "description": "Quarterly permanent XML snapshot (versioned) of AOP-Wiki content suitable for citation and archival use", "format": "xml", "id": "aop-wiki.quarterly-xml", "latest_version": "2026-04-01", "name": "AOP-Wiki Quarterly XML Snapshot", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://aopwiki.org/downloads"}, {"category": "Product", "description": "Nightly XML export (rolling) containing latest AOP-Wiki content (overwritten daily)", "format": "xml", "id": "aop-wiki.nightly-xml", "name": "AOP-Wiki Nightly XML Export", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_file_size": 9933339, "product_url": "https://aopwiki.org/downloads/aop-wiki-xml.gz"}, {"category": "Product", "description": "Tab-delimited subset listing AOP to Key Event (including MIE, intermediate KE, and Adverse Outcome) associations", "format": "tsv", "id": "aop-wiki.ke-overview", "name": "AOP-Wiki Key Events TSV", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_file_size": 238066, "product_url": "https://aopwiki.org/downloads/aop_ke_mie_ao.tsv"}, {"category": "Product", "description": "Tab-delimited subset listing Key Event Relationships (KERs) with evidence and quantitative understanding indicators", "format": "tsv", "id": "aop-wiki.ker", "name": "AOP-Wiki Key Event Relationships TSV", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_file_size": 189389, "product_url": "https://aopwiki.org/downloads/aop_ke_ker.tsv"}, {"category": "Product", "description": "Tab-delimited subset of Key Event Components (actions, biological objects/processes with ontology references)", "format": "tsv", "id": "aop-wiki.ke-components", "name": "AOP-Wiki Key Event Components TSV", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_file_size": 291132, "product_url": "https://aopwiki.org/downloads/aop_ke_ec.tsv"}, {"category": "Product", "description": "Per-AOP dynamic XML feed accessible via each AOP page (XML button) for up-to-minute content retrieval", "format": "xml", "id": "aop-wiki.dynamic-aop-xml", "name": "AOP-Wiki Dynamic AOP XML Feed", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://aopwiki.org/aops"}, {"category": "DocumentationProduct", "description": "This document is the AOP Developers' Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways (AOPs). The Guidance Document provides a historical background for the AOP development programme, and outlines the elements required to construct an AOP as well as the principles of the AOP framework.", "format": "http", "id": "aop-wiki.devhandbook", "name": "AOP Developers' Handbook", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://aopwiki.org/handbooks/4"}, {"category": "Product", "description": "The EPA has developed the Adverse Outcome Pathway Database (AOP-DB) to better characterize adverse outcomes of toxicological interest that are relevant to human health and the environment. Since its inception, the AOP-DB has been developed with the aim of integrating AOP molecular target information with other publicly available datasets to facilitate computational analyses of AOP information.", "format": "http", "id": "aop-db.data", "name": "AOP-DB Data", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "1000genomes"}, {"relation_type": "prov:hadPrimarySource", "source": "aop-db"}, {"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}, {"relation_type": "prov:hadPrimarySource", "source": "ctd"}, {"relation_type": "prov:hadPrimarySource", "source": "disgenet"}, {"relation_type": "prov:hadPrimarySource", "source": "ensembl"}, {"relation_type": "prov:hadPrimarySource", "source": "gwascatalog"}, {"relation_type": "prov:hadPrimarySource", "source": "ncbigene"}, {"relation_type": "prov:hadPrimarySource", "source": "string"}, {"relation_type": "prov:hadPrimarySource", "source": "toxcast"}], "product_url": "https://catalog.data.gov/dataset/adverse-outcome-pathway-database-aop-db-version-2"}, {"category": "ProgrammingInterface", "connection_url": "https://aopdb.rdf.bigcat-bioinformatics.org/", "description": "OpenRiskNet Virtuoso SPARQL endpoint loaded with RDF of the EPA AOP-DB for querying integrated AOP, gene, chemical, disease, tissue, pathway, orthology, ontology, and gene interaction relationships.", "format": "http", "id": "aop-db.sparql", "is_public": true, "name": "AOP-DB SPARQL Endpoint", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-db"}, {"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://openrisknet.org/e-infrastructure/services/147/"}, {"category": "GraphProduct", "description": "RDF knowledge graph (Turtle) repackaging AOP-Wiki data as an open knowledge graph", "format": "ttl", "id": "biobricks-aopwiki.graph", "name": "BioBricks AOP-Wiki Graph", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "biobricks-aopwiki"}, {"relation_type": "prov:wasDerivedFrom", "source": "aop-wiki"}], "product_url": "https://github.com/biobricks-ai/aopwikirdf-kg", "warnings": ["File was not able to be retrieved when checked on 2026-07-10: HTTP 404 error when accessing file", "File was not able to be retrieved when checked on 2026-07-15: HTTP 404 error when accessing file"]}]
{"activity_status": "active", "category": "DataSource", "collection": ["aop", "ber"], "contacts": [{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://aopwiki.org/info_pages/10"}], "label": "AOP-Wiki Coordination Group"}], "creation_date": "2025-09-04T00:00:00Z", "description": "The AOP-Wiki is the primary collaborative authoring and curation interface for the Adverse Outcome Pathway Knowledge Base (AOP-KB). It enables the community to develop, review, browse, and export Adverse Outcome Pathways (AOPs) linking molecular initiating events through key events to adverse outcomes relevant to human and ecological risk assessment. Structured exports (XML and tabular subsets) support computational toxicology, ontology mapping, and integration into predictive assessment workflows.", "domains": ["toxicology", "environment", "pathways"], "homepage_url": "https://aopwiki.org/", "id": "aop-wiki", "last_modified_date": "2026-05-26T00:00:00Z", "layout": "resource_detail", "license": {"id": "https://aopwiki.org/", "label": "Varies"}, "name": "AOP-Wiki", "products": [{"category": "GraphicalInterface", "description": "Web portal for browsing, authoring, and reviewing AOPs, key events (KEs), key event relationships (KERs), stressors, and supporting documentation", "format": "http", "id": "aop-wiki.portal", "name": "AOP-Wiki Portal", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://aopwiki.org/"}, {"category": "ProgrammingInterface", "connection_url": "https://aopwiki-rdf.prod.openrisknet.org/", "description": "OpenRiskNet SPARQL endpoint loaded with RDF converted from AOP-Wiki quarterly XML dumps for querying AOPs, key events, key event relationships, and stressors.", "format": "http", "id": "aop-wiki.sparql", "is_public": true, "name": "AOP-Wiki SPARQL Endpoint", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://openrisknet.org/e-infrastructure/services/133/"}, {"category": "Product", "description": "Quarterly permanent XML snapshot (versioned) of AOP-Wiki content suitable for citation and archival use", "format": "xml", "id": "aop-wiki.quarterly-xml", "latest_version": "2026-04-01", "name": "AOP-Wiki Quarterly XML Snapshot", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://aopwiki.org/downloads"}, {"category": "Product", "description": "Nightly XML export (rolling) containing latest AOP-Wiki content (overwritten daily)", "format": "xml", "id": "aop-wiki.nightly-xml", "name": "AOP-Wiki Nightly XML Export", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_file_size": 9933339, "product_url": "https://aopwiki.org/downloads/aop-wiki-xml.gz"}, {"category": "Product", "description": "Tab-delimited subset listing AOP to Key Event (including MIE, intermediate KE, and Adverse Outcome) associations", "format": "tsv", "id": "aop-wiki.ke-overview", "name": "AOP-Wiki Key Events TSV", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_file_size": 238066, "product_url": "https://aopwiki.org/downloads/aop_ke_mie_ao.tsv"}, {"category": "Product", "description": "Tab-delimited subset listing Key Event Relationships (KERs) with evidence and quantitative understanding indicators", "format": "tsv", "id": "aop-wiki.ker", "name": "AOP-Wiki Key Event Relationships TSV", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_file_size": 189389, "product_url": "https://aopwiki.org/downloads/aop_ke_ker.tsv"}, {"category": "Product", "description": "Tab-delimited subset of Key Event Components (actions, biological objects/processes with ontology references)", "format": "tsv", "id": "aop-wiki.ke-components", "name": "AOP-Wiki Key Event Components TSV", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_file_size": 291132, "product_url": "https://aopwiki.org/downloads/aop_ke_ec.tsv"}, {"category": "Product", "description": "Per-AOP dynamic XML feed accessible via each AOP page (XML button) for up-to-minute content retrieval", "format": "xml", "id": "aop-wiki.dynamic-aop-xml", "name": "AOP-Wiki Dynamic AOP XML Feed", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://aopwiki.org/aops"}, {"category": "DocumentationProduct", "description": "This document is the AOP Developers' Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways (AOPs). The Guidance Document provides a historical background for the AOP development programme, and outlines the elements required to construct an AOP as well as the principles of the AOP framework.", "format": "http", "id": "aop-wiki.devhandbook", "name": "AOP Developers' Handbook", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://aopwiki.org/handbooks/4"}, {"category": "Product", "description": "The EPA has developed the Adverse Outcome Pathway Database (AOP-DB) to better characterize adverse outcomes of toxicological interest that are relevant to human health and the environment. Since its inception, the AOP-DB has been developed with the aim of integrating AOP molecular target information with other publicly available datasets to facilitate computational analyses of AOP information.", "format": "http", "id": "aop-db.data", "name": "AOP-DB Data", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "1000genomes"}, {"relation_type": "prov:hadPrimarySource", "source": "aop-db"}, {"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}, {"relation_type": "prov:hadPrimarySource", "source": "ctd"}, {"relation_type": "prov:hadPrimarySource", "source": "disgenet"}, {"relation_type": "prov:hadPrimarySource", "source": "ensembl"}, {"relation_type": "prov:hadPrimarySource", "source": "gwascatalog"}, {"relation_type": "prov:hadPrimarySource", "source": "ncbigene"}, {"relation_type": "prov:hadPrimarySource", "source": "string"}, {"relation_type": "prov:hadPrimarySource", "source": "toxcast"}], "product_url": "https://catalog.data.gov/dataset/adverse-outcome-pathway-database-aop-db-version-2"}, {"category": "ProgrammingInterface", "connection_url": "https://aopdb.rdf.bigcat-bioinformatics.org/", "description": "OpenRiskNet Virtuoso SPARQL endpoint loaded with RDF of the EPA AOP-DB for querying integrated AOP, gene, chemical, disease, tissue, pathway, orthology, ontology, and gene interaction relationships.", "format": "http", "id": "aop-db.sparql", "is_public": true, "name": "AOP-DB SPARQL Endpoint", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "aop-db"}, {"relation_type": "prov:hadPrimarySource", "source": "aop-wiki"}], "product_url": "https://openrisknet.org/e-infrastructure/services/147/"}, {"category": "GraphProduct", "description": "RDF knowledge graph (Turtle) repackaging AOP-Wiki data as an open knowledge graph", "format": "ttl", "id": "biobricks-aopwiki.graph", "name": "BioBricks AOP-Wiki Graph", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "biobricks-aopwiki"}, {"relation_type": "prov:wasDerivedFrom", "source": "aop-wiki"}], "product_url": "https://github.com/biobricks-ai/aopwikirdf-kg", "warnings": ["File was not able to be retrieved when checked on 2026-07-10: HTTP 404 error when accessing file", "File was not able to be retrieved when checked on 2026-07-15: HTTP 404 error when accessing file"]}], "taxon": ["NCBITaxon:9606"], "version": "2.8"}