PRISM
PRISM (Profiling Relative Inhibition Simultaneously in Mixtures) is a high-throughput drug screening technology developed by the Broad Institute that measures the sensitivity of cancer cell lines to therapeutic compounds. PRISM uses DNA barcoding to pool hundreds of cell lines together, enabling massively parallel drug screening at unprecedented scale. The platform is integrated into the Cancer Dependency Map (DepMap) project and provides comprehensive dose-response data for drug-cancer cell line interactions.
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"publications": [{"authors": ["Steven M Corsello", "Rohith T Nagari", "Ryan D Spangler", "Jordan Rossen", "Mustafa Kocak", "Todd R Golub"], "doi": "10.1038/s43018-019-0018-6", "id": "doi:10.1038/s43018-019-0018-6", "journal": "Nature Cancer", "preferred": true, "title": "Discovering the anticancer potential of non-oncology drugs by systematic viability profiling", "year": "2020"}], "synonyms": ["PRISM", "Profiling Relative Inhibition Simultaneously in Mixtures"], "taxon": ["NCBITaxon:9606"]}