TERA: Toxicological Effect and Risk Assessment Knowledge Graph
The Toxicological Effect and Risk Assessment (TERA) Knowledge Graph is an integrated knowledge graph for ecological risk assessment based on chemical effect data from U.S. EPA ECOTOX. TERA aligns toxicological data to non-proprietary identifiers using ontology alignment tools and external sources such as Wikidata, enabling the use of external chemical knowledge graphs including ChEBI, PubChem, and MeSH. The knowledge graph also includes aggregated data from NCBI Taxonomy and Encyclopedia of Life (EOL) trait data. By linking ECOTOX to external sources, TERA enables the extrapolation of chemical effect data, extending the reach of ecological risk assessment while limiting the need for laboratory experiments. The knowledge graph has been applied to predict adverse biological effects of chemicals using knowledge graph embeddings and supports various applications in environmental toxicology and risk assessment.

[{"category": "Individual", "contact_details": [{"contact_type": "github", "value": "Erik-BM"}], "label": "Erik B. Myklebust"}]
[{"category": "DocumentationProduct", "description": "API documentation for the TERA knowledge graph package", "format": "http", "id": "tera.documentation", "name": "TERA Documentation", "product_url": "https://niva-knowledge-graph.github.io/TERA/"}, {"category": "Product", "description": "TERA knowledge graph dataset snapshot version 1.1.0 hosted on Zenodo, including NT files and CSV mappings", "format": "http", "id": "tera.zenodo-dataset", "license": {"id": "https://creativecommons.org/licenses/by/4.0/", "label": "CC-BY 4.0"}, "name": "TERA Knowledge Graph Dataset (Zenodo)", "product_file_size": 5905580032, "product_url": "https://zenodo.org/records/4244313"}, {"category": "Product", "description": "Chemical data from EPA ECOTOX in N-Triples RDF format", "format": "ntriples", "id": "tera.ecotox-chemical-nt", "name": "ECOTOX Chemical Data (N-Triples)", "product_file_size": 680300, "product_url": "https://zenodo.org/records/4244313/files/ecotox_chemical.nt"}, {"category": "Product", "description": "Taxonomy data from EPA ECOTOX in N-Triples RDF format", "format": "ntriples", "id": "tera.ecotox-taxonomy-nt", "name": "ECOTOX Taxonomy Data (N-Triples)", "product_file_size": 22800000, "product_url": "https://zenodo.org/records/4244313/files/ecotox_taxonomy.nt"}, {"category": "Product", "description": "Chemical effects data in N-Triples RDF format", "format": "ntriples", "id": "tera.effects-nt", "name": "Effects Data (N-Triples)", "product_file_size": 1000000000, "product_url": "https://zenodo.org/records/4244313/files/effects.nt"}, {"category": "Product", "description": "MeSH (Medical Subject Headings) data in N-Triples RDF format", "format": "ntriples", "id": "tera.mesh-nt", "name": "MeSH Data (N-Triples)", "product_file_size": 2100000000, "product_url": "https://zenodo.org/records/4244313/files/mesh.nt"}, {"category": "Product", "description": "NCBI Taxonomy data in N-Triples RDF format", "format": "ntriples", "id": "tera.ncbi-nt", "name": "NCBI Taxonomy Data (N-Triples)", "product_file_size": 1400000000, "product_url": "https://zenodo.org/records/4244313/files/ncbi.nt"}, {"category": "Product", "description": "Encyclopedia of Life traits data in N-Triples RDF format", "format": "ntriples", "id": "tera.traits-nt", "name": "EOL Traits Data (N-Triples)", "product_file_size": 968000000, "product_url": "https://zenodo.org/records/4244313/files/traits.nt"}, {"category": "MappingProduct", "description": "Mapping file linking CAS Registry Numbers to MeSH identifiers", "format": "csv", "id": "tera.cas-to-mesh-csv", "name": "CAS to MeSH Mapping (CSV)", "product_file_size": 109400, "product_url": "https://zenodo.org/records/4244313/files/cas_to_mesh.csv"}, {"category": "MappingProduct", "description": "Mapping file linking ChEBI identifiers to MeSH identifiers", "format": "csv", "id": "tera.chebi-to-mesh-csv", "name": "ChEBI to MeSH Mapping (CSV)", "product_file_size": 78600, "product_url": "https://zenodo.org/records/4244313/files/chebi_to_mesh.csv"}, {"category": "MappingProduct", "description": "Mapping file linking ChEMBL identifiers to MeSH identifiers", "format": "csv", "id": "tera.chembl-to-mesh-csv", "name": "ChEMBL to MeSH Mapping (CSV)", "product_file_size": 108500, "product_url": "https://zenodo.org/records/4244313/files/chembl_to_mesh.csv"}, {"category": "MappingProduct", "description": "Mapping file linking PubChem compound identifiers (CID) to MeSH identifiers", "format": "csv", "id": "tera.cid-to-mesh-csv", "name": "PubChem CID to MeSH Mapping (CSV)", "product_file_size": 108000, "product_url": "https://zenodo.org/records/4244313/files/cid_to_mesh.csv"}, {"category": "MappingProduct", "description": "Mapping file linking NCBI Taxonomy identifiers to Encyclopedia of Life identifiers", "format": "csv", "id": "tera.ncbi-to-eol-csv", "name": "NCBI to EOL Mapping (CSV)", "product_file_size": 3800000, "product_url": "https://zenodo.org/records/4244313/files/ncbi_to_eol.csv"}, {"category": "ProgrammingInterface", "description": "Python package providing APIs for data aggregation, integration, and access of TERA knowledge graph", "format": "python", "id": "tera.python-package", "name": "TERA Python Package", "repository": "https://github.com/NIVA-Knowledge-Graph/TERA"}]
{"activity_status": "active", "category": "KnowledgeGraph", "contacts": [{"category": "Individual", "contact_details": [{"contact_type": "github", "value": "Erik-BM"}], "label": "Erik B. Myklebust"}], "creation_date": "2025-10-28T00:00:00Z", "description": "The Toxicological Effect and Risk Assessment (TERA) Knowledge Graph is an integrated knowledge graph for ecological risk assessment based on chemical effect data from U.S. EPA ECOTOX. TERA aligns toxicological data to non-proprietary identifiers using ontology alignment tools and external sources such as Wikidata, enabling the use of external chemical knowledge graphs including ChEBI, PubChem, and MeSH. The knowledge graph also includes aggregated data from NCBI Taxonomy and Encyclopedia of Life (EOL) trait data. By linking ECOTOX to external sources, TERA enables the extrapolation of chemical effect data, extending the reach of ecological risk assessment while limiting the need for laboratory experiments. The knowledge graph has been applied to predict adverse biological effects of chemicals using knowledge graph embeddings and supports various applications in environmental toxicology and risk assessment.\n", "domains": ["toxicology", "environment", "biological systems"], "evaluation_page": "resource/tera/tera_eval_automated.html", "homepage_url": "https://niva-knowledge-graph.github.io/TERA/", "id": "tera", "last_modified_date": "2025-10-28T00:00:00Z", "layout": "resource_detail", "license": {"id": "https://opensource.org/licenses/MIT", "label": "MIT License"}, "name": "TERA: Toxicological Effect and Risk Assessment Knowledge Graph", "products": [{"category": "DocumentationProduct", "description": "API documentation for the TERA knowledge graph package", "format": "http", "id": "tera.documentation", "name": "TERA Documentation", "product_url": "https://niva-knowledge-graph.github.io/TERA/"}, {"category": "Product", "description": "TERA knowledge graph dataset snapshot version 1.1.0 hosted on Zenodo, including NT files and CSV mappings", "format": "http", "id": "tera.zenodo-dataset", "license": {"id": "https://creativecommons.org/licenses/by/4.0/", "label": "CC-BY 4.0"}, "name": "TERA Knowledge Graph Dataset (Zenodo)", "product_file_size": 5905580032, "product_url": "https://zenodo.org/records/4244313"}, {"category": "Product", "description": "Chemical data from EPA ECOTOX in N-Triples RDF format", "format": "ntriples", "id": "tera.ecotox-chemical-nt", "name": "ECOTOX Chemical Data (N-Triples)", "product_file_size": 680300, "product_url": "https://zenodo.org/records/4244313/files/ecotox_chemical.nt"}, {"category": "Product", "description": "Taxonomy data from EPA ECOTOX in N-Triples RDF format", "format": "ntriples", "id": "tera.ecotox-taxonomy-nt", "name": "ECOTOX Taxonomy Data (N-Triples)", "product_file_size": 22800000, "product_url": "https://zenodo.org/records/4244313/files/ecotox_taxonomy.nt"}, {"category": "Product", "description": "Chemical effects data in N-Triples RDF format", "format": "ntriples", "id": "tera.effects-nt", "name": "Effects Data (N-Triples)", "product_file_size": 1000000000, "product_url": "https://zenodo.org/records/4244313/files/effects.nt"}, {"category": "Product", "description": "MeSH (Medical Subject Headings) data in N-Triples RDF format", "format": "ntriples", "id": "tera.mesh-nt", "name": "MeSH Data (N-Triples)", "product_file_size": 2100000000, "product_url": "https://zenodo.org/records/4244313/files/mesh.nt"}, {"category": "Product", "description": "NCBI Taxonomy data in N-Triples RDF format", "format": "ntriples", "id": "tera.ncbi-nt", "name": "NCBI Taxonomy Data (N-Triples)", "product_file_size": 1400000000, "product_url": "https://zenodo.org/records/4244313/files/ncbi.nt"}, {"category": "Product", "description": "Encyclopedia of Life traits data in N-Triples RDF format", "format": "ntriples", "id": "tera.traits-nt", "name": "EOL Traits Data (N-Triples)", "product_file_size": 968000000, "product_url": "https://zenodo.org/records/4244313/files/traits.nt"}, {"category": "MappingProduct", "description": "Mapping file linking CAS Registry Numbers to MeSH identifiers", "format": "csv", "id": "tera.cas-to-mesh-csv", "name": "CAS to MeSH Mapping (CSV)", "product_file_size": 109400, "product_url": "https://zenodo.org/records/4244313/files/cas_to_mesh.csv"}, {"category": "MappingProduct", "description": "Mapping file linking ChEBI identifiers to MeSH identifiers", "format": "csv", "id": "tera.chebi-to-mesh-csv", "name": "ChEBI to MeSH Mapping (CSV)", "product_file_size": 78600, "product_url": "https://zenodo.org/records/4244313/files/chebi_to_mesh.csv"}, {"category": "MappingProduct", "description": "Mapping file linking ChEMBL identifiers to MeSH identifiers", "format": "csv", "id": "tera.chembl-to-mesh-csv", "name": "ChEMBL to MeSH Mapping (CSV)", "product_file_size": 108500, "product_url": "https://zenodo.org/records/4244313/files/chembl_to_mesh.csv"}, {"category": "MappingProduct", "description": "Mapping file linking PubChem compound identifiers (CID) to MeSH identifiers", "format": "csv", "id": "tera.cid-to-mesh-csv", "name": "PubChem CID to MeSH Mapping (CSV)", "product_file_size": 108000, "product_url": "https://zenodo.org/records/4244313/files/cid_to_mesh.csv"}, {"category": "MappingProduct", "description": "Mapping file linking NCBI Taxonomy identifiers to Encyclopedia of Life identifiers", "format": "csv", "id": "tera.ncbi-to-eol-csv", "name": "NCBI to EOL Mapping (CSV)", "product_file_size": 3800000, "product_url": "https://zenodo.org/records/4244313/files/ncbi_to_eol.csv"}, {"category": "ProgrammingInterface", "description": "Python package providing APIs for data aggregation, integration, and access of TERA knowledge graph", "format": "python", "id": "tera.python-package", "name": "TERA Python Package", "repository": "https://github.com/NIVA-Knowledge-Graph/TERA"}], "publications": [{"authors": ["Erik Bryhn Myklebust", "Ernesto Jimenez-Ruiz", "Jiaoyan Chen", "Raoul Wolf", "Knut Erik Tollefsen"], "category": "Publication", "id": "https://doi.org/10.48550/arXiv.1908.10128", "journal": "arXiv:1908.10128", "preferred": true, "title": "TERA: the Toxicological Effect and Risk Assessment Knowledge Graph", "year": "2019"}, {"authors": ["Erik B. Myklebust", "Ernesto Jimenez-Ruiz", "Jiaoyan Chen", "Raoul Wolf", "Knut Erik Tollefsen"], "category": "Publication", "id": "https://doi.org/10.3233/sw-222804", "journal": "Semantic Web Journal", "preferred": false, "title": "Prediction of Adverse Biological Effects of Chemicals Using Knowledge Graph Embeddings", "year": "2022"}], "repository": "https://github.com/NIVA-Knowledge-Graph/TERA"}