ReDrugs
ReDrugs is a probabilistic knowledge graph for drug repositioning that integrates drug-target, protein-protein, and disease-gene interactions from multiple databases. The system uses evidence-weighted nanopublications to assign confidence scores to interactions based on experimental methods and manual curation. ReDrugs was designed to identify novel drug candidates for diseases, particularly melanoma, by filtering and analyzing systems biology networks with probabilistic methods. The platform included both a web interface and API for exploring molecular interaction networks. The web interface appears to be no longer accessible.
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{"activity_status": "inactive", "category": "KnowledgeGraph", "creation_date": "2025-11-22T00:00:00Z", "description": "ReDrugs is a probabilistic knowledge graph for drug repositioning that integrates drug-target, protein-protein, and disease-gene interactions from multiple databases. The system uses evidence-weighted nanopublications to assign confidence scores to interactions based on experimental methods and manual curation. ReDrugs was designed to identify novel drug candidates for diseases, particularly melanoma, by filtering and analyzing systems biology networks with probabilistic methods. The platform included both a web interface and API for exploring molecular interaction networks. The web interface appears to be no longer accessible.", "domains": ["drug discovery", "systems biology", "biomedical", "pharmacology", "translational"], "evaluation_page": "resource/redrugs/redrugs_eval_automated.html", "homepage_url": "http://redrugs.tw.rpi.edu/", "id": "redrugs", "last_modified_date": "2025-11-22T00:00:00Z", "layout": "resource_detail", "license": {"id": "https://creativecommons.org/licenses/by/4.0/", "label": "CC BY 4.0", "logo": "http://mirrors.creativecommons.org/presskit/buttons/80x15/png/by.png"}, "name": "ReDrugs", "products": [{"category": "GraphicalInterface", "description": "Interactive web interface for exploring drug-disease networks with probabilistic filtering and graph visualization", "id": "redrugs.web", "name": "ReDrugs Web Interface", "original_source": ["redrugs"], "product_url": "http://redrugs.tw.rpi.edu/"}, {"category": "ProgrammingInterface", "description": "SADI web services API for querying the knowledge graph including resource search, interaction lookup, and network expansion", "id": "redrugs.api", "name": "ReDrugs API", "original_source": ["redrugs"], "product_url": "http://redrugs.tw.rpi.edu/api/"}], "publications": [{"authors": ["McCusker JP", "Dumontier M", "Yan R", "He S", "Dordick JS", "McGuinness DL"], "doi": "10.7717/peerj-cs.106", "id": "doi:10.7717/peerj-cs.106", "journal": "PeerJ Computer Science", "title": "Finding melanoma drugs through a probabilistic knowledge graph", "year": "2017"}], "repository": "https://data.rpi.edu/xmlui/handle/10833/1760", "synonyms": ["ReDrugS"], "taxon": ["NCBITaxon:9606"]}