name: Project Achilles
description: Project Achilles is a systematic effort aimed at identifying and cataloging gene essentiality across hundreds of genomically characterized cancer cell lines. Achilles uses genome-scale RNAi and CRISPR-Cas9 genetic perturbation reagents to silence or knockout individual genes and identify those genes that affect cell survival.
contacts: [{"category": "Organization", "contact_details": [{"contact_type": "email", "value": "achilles@broadinstitute.org"}, {"contact_type": "url", "value": "https://depmap.org/portal/achilles/"}], "label": "Project Achilles, Broad Institute"}]
products: [{"category": "Product", "description": "Network embeddings of the Bioteque graph that represent biological entities and their associations", "id": "bioteque.embeddings", "name": "Bioteque Embeddings", "original_source": ["chebi", "cosmic", "achilles", "depmap", "ccle", "gdsc", "cellosaurus", "clue", "ctd", "pharmacodb", "prism", "drugbank", "lincs", "compartments", "offsides", "sider", "drugcentral", "repohub", "chemicalchecker", "repodb", "disgenet", "opentargets", "creeds", "interpro", "reactome", "tissues", "dorothea", "progeny", "gtex", "hpa", "go", "corum", "huri", "intact", "omnipath", "string", "bto"], "product_url": "https://bioteque.irbbarcelona.org/downloads/embeddings", "secondary_source": ["bioteque"]}]
raw_data: {"activity_status": "active", "category": "DataSource", "contacts": [{"category": "Organization", "contact_details": [{"contact_type": "email", "value": "achilles@broadinstitute.org"}, {"contact_type": "url", "value": "https://depmap.org/portal/achilles/"}], "label": "Project Achilles, Broad Institute"}], "curators": [{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://depmap.org/"}], "label": "DepMap"}], "description": "Project Achilles is a systematic effort aimed at identifying and cataloging gene essentiality across hundreds of genomically characterized cancer cell lines. Achilles uses genome-scale RNAi and CRISPR-Cas9 genetic perturbation reagents to silence or knockout individual genes and identify those genes that affect cell survival.", "domains": ["biomedical", "genomics", "health"], "homepage_url": "https://depmap.org/portal/achilles/", "id": "achilles", "layout": "resource_detail", "license": {"id": "https://depmap.org/portal/terms/", "label": "DepMap Terms of Use"}, "name": "Project Achilles", "products": [{"category": "Product", "description": "Network embeddings of the Bioteque graph that represent biological entities and their associations", "id": "bioteque.embeddings", "name": "Bioteque Embeddings", "original_source": ["chebi", "cosmic", "achilles", "depmap", "ccle", "gdsc", "cellosaurus", "clue", "ctd", "pharmacodb", "prism", "drugbank", "lincs", "compartments", "offsides", "sider", "drugcentral", "repohub", "chemicalchecker", "repodb", "disgenet", "opentargets", "creeds", "interpro", "reactome", "tissues", "dorothea", "progeny", "gtex", "hpa", "go", "corum", "huri", "intact", "omnipath", "string", "bto"], "product_url": "https://bioteque.irbbarcelona.org/downloads/embeddings", "secondary_source": ["bioteque"]}], "publications": [{"authors": ["Tsherniak A", "Vazquez F", "Montgomery PG", "Weir BA", "Kryukov G", "Cowley GS"], "doi": "10.1016/j.cell.2017.06.010", "id": "doi:10.1016/j.cell.2017.06.010", "journal": "Cell", "title": "Defining a Cancer Dependency Map", "year": "2017"}]}