Tox21 (Toxicology in the 21st Century)
Tox21 (Toxicology in the 21st Century) is a US federal collaboration among the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS), the US Environmental Protection Agency (EPA), the National Toxicology Program at the National Institute of Environmental Health Sciences (NTP/NIEHS), and the US Food and Drug Administration (FDA). The consortium uses quantitative high-throughput screening to test a library of approximately 10,000 chemicals, including environmental compounds and approved drugs, against a panel of biological assays that probe nuclear-receptor signaling and cellular stress-response pathways. The resulting data are used to predict potential toxicity and to prioritize chemicals for further, more targeted testing.
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