Cancer Therapeutics Response Portal
The Cancer Therapeutics Response Portal (CTRP) is a comprehensive cancer cell line profiling resource that links genetic, lineage, and other cellular features of cancer cell lines to small-molecule sensitivity with the goal of accelerating discovery of patient-matched cancer therapeutics. Developed by researchers at the Broad Institute Center for the Science of Therapeutics as part of the NCI Cancer Target Discovery and Development (CTD2) Network, CTRP measured the sensitivity of 860 deeply characterized human cancer cell lines encompassing 25 lineages to an Informer Set of 481 small-molecule probes and drugs that selectively target distinct nodes in cell circuitry. The resource provides correlations between small-molecule sensitivity patterns and basal gene expression profiles from the Cancer Cell Line Encyclopedia (CCLE) across approximately 19,000 transcripts, enabling identification of mechanisms of action, cellular targets, metabolic processing pathways, and drug resistance mechanisms. CTRP measurements were performed over 16-point concentration ranges in duplicate using automated high-throughput workflows, with cellular ATP levels assessed 72 hours after compound treatment as a surrogate for viability. The portal provides interactive tools for exploring clustering by small molecule and cell line, enrichment analyses for annotations, correlations to copy-number and gene-expression data, on-the-fly correlation analysis, box-whisker visualizations, drill-down to scatter plots and concentration-response curves, and filtering by lineage, subtype, or growth mode. CTRP enables correlation of chemical sensitivity with basal gene expression to reveal direct target connections, target pathway relationships, metabolic activation mechanisms, small-molecule import and export mechanisms, and novel therapeutic targets, supporting the identification of predictive biomarkers for patient-matched therapeutics and the systematic characterization of small-molecule mechanisms of action.
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