name: ChEA-KG
description: ChEA-KG is a knowledge graph built around the ChEA (ChIP Enrichment Analysis) database that integrates chromatin immunoprecipitation sequencing data with transcription factor binding sites, gene regulatory networks, and functional annotations to provide comprehensive insights into transcriptional regulation across cell types and conditions.
contacts: [{"category": "Organization", "contact_details": [{"contact_type": "email", "value": "avi.maayan@mssm.edu"}, {"contact_type": "url", "value": "https://labs.icahn.mssm.edu/maayanlab/"}], "label": "Ma'ayan Laboratory"}]
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raw_data: {"activity_status": "active", "category": "KnowledgeGraph", "contacts": [{"category": "Organization", "contact_details": [{"contact_type": "email", "value": "avi.maayan@mssm.edu"}, {"contact_type": "url", "value": "https://labs.icahn.mssm.edu/maayanlab/"}], "label": "Ma'ayan Laboratory"}], "creation_date": "2025-09-23T00:00:00Z", "description": "ChEA-KG is a knowledge graph built around the ChEA (ChIP Enrichment Analysis) database that integrates chromatin immunoprecipitation sequencing data with transcription factor binding sites, gene regulatory networks, and functional annotations to provide comprehensive insights into transcriptional regulation across cell types and conditions.", "domains": ["biomedical", "genomics", "systems biology"], "homepage_url": "https://maayanlab.cloud/chea-kg/", "id": "chea-kg", "last_modified_date": "2025-09-23T00:00:00Z", "layout": "resource_detail", "license": {"id": "https://creativecommons.org/licenses/by/4.0/", "label": "CC BY 4.0", "logo": "http://mirrors.creativecommons.org/presskit/buttons/80x15/png/by.png"}, "name": "ChEA-KG", "products": [{"category": "GraphicalInterface", "description": "Interactive web interface for exploring transcription factor-target gene relationships with regulatory network visualization", "format": "http", "id": "chea-kg.portal", "name": "ChEA-KG Explorer", "product_url": "https://maayanlab.cloud/chea-kg/"}, {"category": "ProgrammingInterface", "description": "RESTful API for programmatic access to ChIP-seq derived transcription factor binding data", "format": "http", "id": "chea-kg.api", "name": "ChEA-KG API", "product_url": "https://maayanlab.cloud/chea-kg/api/"}, {"category": "GraphProduct", "description": "Neo4j database containing transcription factors, target genes, and regulatory relationships from ChIP-seq studies", "dump_format": "neo4j", "format": "neo4j", "id": "chea-kg.graph", "name": "ChEA-KG Database"}, {"category": "Product", "description": "Processed ChIP-seq datasets with transcription factor binding sites and target gene annotations", "id": "chea-kg.chipseq", "name": "ChEA ChIP-seq Data", "product_url": "https://maayanlab.cloud/chea3/index.html#content4-13"}], "publications": [{"authors": ["Keenan AB", "Torre D", "Lachmann A", "Leong AK", "Wojtkiewicz ML", "Utti V", "Jagodnik KM", "Kropiwnicki E", "Wang Z", "Ma'ayan A"], "id": "doi:10.1093/nar/gkz446", "journal": "Nucleic Acids Research", "preferred": true, "title": "ChEA3: transcription factor enrichment analysis by orthogonal omics integration", "year": "2019"}], "repository": "https://github.com/MaayanLab/chea-kg"}