BRENDA
BRENDA (BRaunschweig ENzyme DAtabase) is the main collection of enzyme functional data available to the scientific community. It provides comprehensive information on enzyme nomenclature, reaction mechanisms, specificity, functional parameters, and enzyme-related disease information. BRENDA integrates biochemical and molecular information from primary literature, patents, and data collections to support enzyme research and applications in biotechnology, medicine, and metabolic engineering. The database is curated at the Leibniz Institute DSMZ and is part of ELIXIR Core Data Resources and the German Network for Bioinformatics Infrastructure (de.NBI).
[]
[{"category": "GraphicalInterface", "description": "Web-based search and browsing interface for enzyme data with advanced query capabilities including EC number classification, organism taxonomy, metabolic pathways, enzyme structures, and functional parameters", "format": "http", "id": "brenda.web", "name": "BRENDA Web Portal", "original_source": ["brenda"], "product_url": "https://www.brenda-enzymes.org/"}, {"category": "ProgrammingInterface", "description": "SOAP web service API providing programmatic access to enzyme data with methods for querying kinetic parameters, substrates, products, organisms, sequences, and other enzyme properties", "format": "http", "id": "brenda.soap", "name": "BRENDA SOAP API", "original_source": ["brenda"], "product_url": "https://www.brenda-enzymes.org/soap.php"}, {"category": "ProgrammingInterface", "description": "SPARQL endpoint for querying BRENDA knowledge graph with semantic web technologies", "format": "http", "id": "brenda.sparql", "name": "BRENDA SPARQL Endpoint", "original_source": ["brenda"], "product_url": "https://sparql.dsmz.de/brenda"}, {"category": "Product", "description": "Downloadable text files containing complete BRENDA enzyme data in structured format", "format": "mixed", "id": "brenda.textfile", "name": "BRENDA Textfile Download", "original_source": ["brenda"], "product_url": "https://www.brenda-enzymes.org/download.php"}, {"category": "Product", "description": "Downloadable JSON files containing complete BRENDA enzyme data with schema documentation", "format": "json", "id": "brenda.json", "name": "BRENDA JSON Download", "original_source": ["brenda"], "product_url": "https://www.brenda-enzymes.org/download.php"}, {"category": "GraphProduct", "description": "The integrative Biomedical Knowledge Hub (iBKH) knowledge graph, harmonizing and integrating information from diverse biomedical resources including DRKG, iDISK, and multiple databases (BRENDA, CTD, DrugBank, KEGG, PharmGKB, Reactome, SIDER, and others).", "id": "ibkh.graph", "name": "iBKH Knowledge Graph", "original_source": ["drkg", "idisk", "brenda", "ctd", "drugbank", "kegg", "pharmgkb", "reactome", "sider", "tissues", "bgee", "doid", "uberon", "cl", "hgnc", "chembl", "chebi"]}]
{"activity_status": "active", "category": "DataSource", "creation_date": "2025-11-19T00:00:00Z", "description": "BRENDA (BRaunschweig ENzyme DAtabase) is the main collection of enzyme functional data available to the scientific community. It provides comprehensive information on enzyme nomenclature, reaction mechanisms, specificity, functional parameters, and enzyme-related disease information. BRENDA integrates biochemical and molecular information from primary literature, patents, and data collections to support enzyme research and applications in biotechnology, medicine, and metabolic engineering. The database is curated at the Leibniz Institute DSMZ and is part of ELIXIR Core Data Resources and the German Network for Bioinformatics Infrastructure (de.NBI).", "domains": ["chemistry and biochemistry", "pathways", "biomedical"], "homepage_url": "https://www.brenda-enzymes.org/", "id": "brenda", "last_modified_date": "2025-11-19T00:00:00Z", "layout": "resource_detail", "license": {"id": "https://creativecommons.org/licenses/by/4.0/", "label": "CC BY 4.0", "logo": "http://mirrors.creativecommons.org/presskit/buttons/80x15/png/by.png"}, "name": "BRENDA", "products": [{"category": "GraphicalInterface", "description": "Web-based search and browsing interface for enzyme data with advanced query capabilities including EC number classification, organism taxonomy, metabolic pathways, enzyme structures, and functional parameters", "format": "http", "id": "brenda.web", "name": "BRENDA Web Portal", "original_source": ["brenda"], "product_url": "https://www.brenda-enzymes.org/"}, {"category": "ProgrammingInterface", "description": "SOAP web service API providing programmatic access to enzyme data with methods for querying kinetic parameters, substrates, products, organisms, sequences, and other enzyme properties", "format": "http", "id": "brenda.soap", "name": "BRENDA SOAP API", "original_source": ["brenda"], "product_url": "https://www.brenda-enzymes.org/soap.php"}, {"category": "ProgrammingInterface", "description": "SPARQL endpoint for querying BRENDA knowledge graph with semantic web technologies", "format": "http", "id": "brenda.sparql", "name": "BRENDA SPARQL Endpoint", "original_source": ["brenda"], "product_url": "https://sparql.dsmz.de/brenda"}, {"category": "Product", "description": "Downloadable text files containing complete BRENDA enzyme data in structured format", "format": "mixed", "id": "brenda.textfile", "name": "BRENDA Textfile Download", "original_source": ["brenda"], "product_url": "https://www.brenda-enzymes.org/download.php"}, {"category": "Product", "description": "Downloadable JSON files containing complete BRENDA enzyme data with schema documentation", "format": "json", "id": "brenda.json", "name": "BRENDA JSON Download", "original_source": ["brenda"], "product_url": "https://www.brenda-enzymes.org/download.php"}, {"category": "GraphProduct", "description": "The integrative Biomedical Knowledge Hub (iBKH) knowledge graph, harmonizing and integrating information from diverse biomedical resources including DRKG, iDISK, and multiple databases (BRENDA, CTD, DrugBank, KEGG, PharmGKB, Reactome, SIDER, and others).", "id": "ibkh.graph", "name": "iBKH Knowledge Graph", "original_source": ["drkg", "idisk", "brenda", "ctd", "drugbank", "kegg", "pharmgkb", "reactome", "sider", "tissues", "bgee", "doid", "uberon", "cl", "hgnc", "chembl", "chebi"]}], "publications": [{"authors": ["Hauenstein, J.", "Jeske, L.", "J\u00e4de, A.", "Krull, M.", "D\u00fcmmer, K.", "Koblitz, J.", "Tietz, A.", "Jahn, D.", "Reimer, L. C.", "Bunk, B."], "doi": "10.1093/nar/gkaf1113", "id": "PMID:41206471", "journal": "Nucleic Acids Research", "title": "BRENDA in 2026: a Global Core Biodata Resource for functional enzyme and metabolic data within the DSMZ Digital Diversity", "year": "2025"}, {"authors": ["Chang, A.", "Jeske, L.", "Ulbrich, S.", "Hofmann, J.", "Koblitz, J.", "Schomburg, I.", "Neumann-Schaal, M.", "Jahn, D.", "Schomburg, D."], "doi": "10.1093/nar/gkaa1025", "id": "PMID:33211880", "journal": "Nucleic Acids Research", "title": "BRENDA, the ELIXIR core data resource in 2021: new developments and updates", "year": "2021"}], "taxon": ["NCBITaxon:131567"]}