Therapeutic Target Database
The Therapeutic Target Database (TTD) is a comprehensive aggregator providing information about known and explored therapeutic protein and nucleic acid targets, targeted diseases, pathway information, and corresponding drugs directed at these targets. TTD 2024 includes extensive druggability information across three perspectives: molecular interactions/regulations, human system profiles, and cell-based expression variations. The database encompasses 3,730 targets (including 532 successful, 1,442 clinical trial, 239 preclinical/patented, and 1,517 literature-reported targets) and 39,862 drugs, with druggability characteristics covering ligand-specific binding pockets, protein-protein interaction networks, microbiota-drug regulations, target similarity profiles, pathway involvements, tissue distributions, and cell-based expression variations across different diseases and perturbations.
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{"activity_status": "active", "category": "Aggregator", "contacts": [{"category": "Individual", "contact_details": [{"contact_type": "email", "value": "zhangyintao@zju.edu.cn"}], "label": "Feng Zhu"}, {"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://idrblab.org/ttd/"}], "label": "College of Pharmaceutical Sciences, Zhejiang University"}, {"category": "Individual", "contact_details": [{"contact_type": "url", "value": "https://bidd.group/index.html#people"}], "label": "Yuzong Chen"}, {"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://bidd.group/index.html#people"}], "label": "Department of Pharmacy, National University of Singapore"}], "creation_date": "2025-10-29T00:00:00Z", "description": "The Therapeutic Target Database (TTD) is a comprehensive aggregator providing information about known and explored therapeutic protein and nucleic acid targets, targeted diseases, pathway information, and corresponding drugs directed at these targets. 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