OARD (Open Annotations for Rare Diseases)
OARD (Open Annotations for Rare Diseases) is a web resource and RESTful API that provides data-driven associations between rare diseases and their phenotypes and co-morbidities, mined from large-scale de-identified electronic health records. Developed by the Weng Lab in the Department of Biomedical Informatics at Columbia University, OARD is built from more than 10 million de-identified patient records drawn from Columbia University Irving Medical Center (CUIMC) and Children's Hospital of Philadelphia (CHOP). Only aggregate frequency and co-occurrence statistics (no individual-level data) are stored, and disease-phenotype association analyses are computed on the fly per query. Diseases are represented using Mondo, OMIM, and Orphanet identifiers and phenotypes using the Human Phenotype Ontology (HPO), with clinical concepts grounded in the OMOP common data model.
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