TFactS
TFactS is a catalogue of literature-curated, signed transcription factor to target gene regulatory interactions, where each interaction records whether a transcription factor up-regulates or down-regulates its target. By comparing these curated "regulons" against differentially expressed genes, TFactS infers the activation or repression state of transcription factors from gene expression (microarray) data. It served as a foundational upstream source for the DoRothEA regulon collection. The original web service at tfacts.org is no longer operational and the domain has been re-registered for unrelated content.
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