Human Reference Protein Interactome Mapping Project
The Human Reference Protein Interactome Mapping Project (HRPIMP) is a systematic effort to map binary protein-protein interactions in human cells. The project produced the Human Reference Interactome (HuRI) database containing high-quality experimentally validated protein-protein interactions. Using systematic yeast two-hybrid (Y2H) screening approaches, HRPIMP mapped interactions for 9,094 proteins, identifying 64,006 binary protein-protein interactions. This comprehensive reference map of the human binary protein interactome provides essential data for understanding cellular mechanisms, disease pathways, and molecular networks. The data is freely available and has been integrated into multiple knowledge bases and research projects including studies of Alzheimer's Disease, cancer, and other complex diseases.
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