FIRE (Frequently Interacting REgions)
FIRE (Frequently Interacting REgions) are genomic regions that participate in an unusually high number of local chromatin interactions, identified from high-throughput chromosome conformation capture (Hi-C) data. They were defined by Schmitt et al. (Cell Reports, 2016), who built a compendium of chromatin contact maps across 14 human primary tissues and cell types and showed that FIREs mark spatially active, cell-type-specific regions of the genome enriched for super-enhancers and disease-associated variants. FIRE serves as an upstream chromatin-architecture data layer in GenomicKB, contributing three-dimensional genome-organization annotations to that knowledge graph.
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