Drug Repurposing Hub
The Drug Repurposing Hub is a curated and annotated collection of FDA-approved drugs, clinical trial drugs, and selected pre-clinical tool compounds from the Broad Institute. The collection contains 7,423 unique compounds targeting 2,255 protein targets, with annotations for 775 drug indications and extensive metadata including structures, mechanisms, and therapeutic areas.
[]
[{"category": "GraphicalInterface", "description": "Web portal for exploring the Drug Repurposing Hub compound collection and annotations", "format": "http", "id": "repohub.portal", "name": "Repurposing Hub Portal", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#home"}, {"category": "GraphicalInterface", "description": "Interactive data portal for searching and exploring compound annotations, targets, mechanisms, and indications", "format": "http", "id": "repohub.data-portal", "name": "Data Portal", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing-app"}, {"category": "Product", "description": "Downloadable drug information file with compound metadata including names, structures, targets, mechanisms, and indications", "format": "http", "id": "repohub.drug-info", "name": "Drug Information Download", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#download", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "Product", "description": "Downloadable sample information file with compound library details and annotations", "format": "http", "id": "repohub.sample-info", "name": "Sample Information Download", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#download", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "Product", "description": "Physical screening library of 5,506 compounds (90% FDA-approved or in clinical trials) available as assay-ready plates", "id": "repohub.screening-library", "name": "Screening Library", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#about", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "Product", "description": "REPO1 subset library available in 5-point, 10-fold dilution series as single-use assay-ready plates", "id": "repohub.repo1-library", "name": "REPO1 Dilution Series Library", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#about", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "Product", "description": "Follow-up compound collection of approximately 2,400 compounds available for secondary studies", "id": "repohub.followup-compounds", "name": "Follow-up Compound Collection", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#about", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "DocumentationProduct", "description": "About page with detailed information on the Drug Repurposing Hub history, team, and usage", "format": "http", "id": "repohub.about", "name": "About the Repurposing Hub", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#about", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "DocumentationProduct", "description": "Case studies demonstrating applications of the Drug Repurposing Hub", "format": "http", "id": "repohub.case-studies", "name": "Case Studies", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#case-studies", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "DocumentationProduct", "description": "Information about conducting screens with the Drug Repurposing Hub library", "format": "http", "id": "repohub.screening-info", "name": "Screening Information", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#screen", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "DocumentationProduct", "description": "Policy document for compound intake and donation to the collection", "format": "pdf", "id": "repohub.intake-policy", "name": "Compound Intake Policy", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_file_size": 57661, "product_url": "https://repo-hub.broadinstitute.org/public/data/Compound_Intake_Policy.pdf", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "Product", "description": "Network embeddings of the Bioteque graph that represent biological entities and their associations", "id": "bioteque.embeddings", "name": "Bioteque Embeddings", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "achilles"}, {"relation_type": "prov:hadPrimarySource", "source": "bioteque"}, {"relation_type": "prov:hadPrimarySource", "source": "bto"}, {"relation_type": "prov:hadPrimarySource", "source": "ccle"}, {"relation_type": "prov:hadPrimarySource", "source": "cellosaurus"}, {"relation_type": "prov:hadPrimarySource", "source": "chebi"}, {"relation_type": "prov:hadPrimarySource", "source": "chemicalchecker"}, {"relation_type": "prov:hadPrimarySource", "source": "clue"}, {"relation_type": "prov:hadPrimarySource", "source": "compartments"}, {"relation_type": "prov:hadPrimarySource", "source": "corum"}, {"relation_type": "prov:hadPrimarySource", "source": "cosmic"}, {"relation_type": "prov:hadPrimarySource", "source": "creeds"}, {"relation_type": "prov:hadPrimarySource", "source": "ctd"}, {"relation_type": "prov:hadPrimarySource", "source": "depmap"}, {"relation_type": "prov:hadPrimarySource", "source": "disgenet"}, {"relation_type": "prov:hadPrimarySource", "source": "dorothea"}, {"relation_type": "prov:hadPrimarySource", "source": "drugbank"}, {"relation_type": "prov:hadPrimarySource", "source": "drugcentral"}, {"relation_type": "prov:hadPrimarySource", "source": "gdsc"}, {"relation_type": "prov:hadPrimarySource", "source": "go"}, {"relation_type": "prov:hadPrimarySource", "source": "gtex"}, {"relation_type": "prov:hadPrimarySource", "source": "hpa"}, {"relation_type": "prov:hadPrimarySource", "source": "huri"}, {"relation_type": "prov:hadPrimarySource", "source": "intact"}, {"relation_type": "prov:hadPrimarySource", "source": "interpro"}, {"relation_type": "prov:hadPrimarySource", "source": "lincs"}, {"relation_type": "prov:hadPrimarySource", "source": "offsides"}, {"relation_type": "prov:hadPrimarySource", "source": "omnipath"}, {"relation_type": "prov:hadPrimarySource", "source": "opentargets"}, {"relation_type": "prov:hadPrimarySource", "source": "pharmacodb"}, {"relation_type": "prov:hadPrimarySource", "source": "prism"}, {"relation_type": "prov:hadPrimarySource", "source": "progeny"}, {"relation_type": "prov:hadPrimarySource", "source": "reactome"}, {"relation_type": "prov:hadPrimarySource", "source": "repodb"}, {"relation_type": "prov:hadPrimarySource", "source": "repohub"}, {"relation_type": "prov:hadPrimarySource", "source": "sider"}, {"relation_type": "prov:hadPrimarySource", "source": "string"}, {"relation_type": "prov:hadPrimarySource", "source": "tissues"}], "product_url": "https://bioteque.irbbarcelona.org/downloads/embeddings"}]
{"activity_status": "active", "category": "DataSource", "creation_date": "2025-09-09T00:00:00Z", "description": "The Drug Repurposing Hub is a curated and annotated collection of FDA-approved drugs, clinical trial drugs, and selected pre-clinical tool compounds from the Broad Institute. 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"http", "id": "repohub.sample-info", "name": "Sample Information Download", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#download", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "Product", "description": "Physical screening library of 5,506 compounds (90% FDA-approved or in clinical trials) available as assay-ready plates", "id": "repohub.screening-library", "name": "Screening Library", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#about", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "Product", "description": "REPO1 subset library available in 5-point, 10-fold dilution series as single-use assay-ready plates", "id": "repohub.repo1-library", "name": "REPO1 Dilution Series Library", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#about", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "Product", "description": "Follow-up compound collection of approximately 2,400 compounds available for secondary studies", "id": "repohub.followup-compounds", "name": "Follow-up Compound Collection", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#about", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "DocumentationProduct", "description": "About page with detailed information on the Drug Repurposing Hub history, team, and usage", "format": "http", "id": "repohub.about", "name": "About the Repurposing Hub", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#about", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "DocumentationProduct", "description": "Case studies demonstrating applications of the Drug Repurposing Hub", "format": "http", "id": "repohub.case-studies", "name": "Case Studies", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#case-studies", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate verification is bypassed."]}, {"category": "DocumentationProduct", "description": "Information about conducting screens with the Drug Repurposing Hub library", "format": "http", "id": "repohub.screening-info", "name": "Screening Information", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "repohub"}], "product_url": "https://repo-hub.broadinstitute.org/repurposing#screen", "warnings": ["Automated HTTPS checks on 2026-05-23 still fail TLS certificate validation for repo-hub.broadinstitute.org, although the endpoint responds with HTTP 200 when certificate 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"bioteque"}, {"relation_type": "prov:hadPrimarySource", "source": "bto"}, {"relation_type": "prov:hadPrimarySource", "source": "ccle"}, {"relation_type": "prov:hadPrimarySource", "source": "cellosaurus"}, {"relation_type": "prov:hadPrimarySource", "source": "chebi"}, {"relation_type": "prov:hadPrimarySource", "source": "chemicalchecker"}, {"relation_type": "prov:hadPrimarySource", "source": "clue"}, {"relation_type": "prov:hadPrimarySource", "source": "compartments"}, {"relation_type": "prov:hadPrimarySource", "source": "corum"}, {"relation_type": "prov:hadPrimarySource", "source": "cosmic"}, {"relation_type": "prov:hadPrimarySource", "source": "creeds"}, {"relation_type": "prov:hadPrimarySource", "source": "ctd"}, {"relation_type": "prov:hadPrimarySource", "source": "depmap"}, {"relation_type": "prov:hadPrimarySource", "source": "disgenet"}, {"relation_type": "prov:hadPrimarySource", "source": "dorothea"}, {"relation_type": "prov:hadPrimarySource", "source": "drugbank"}, {"relation_type": "prov:hadPrimarySource", "source": "drugcentral"}, {"relation_type": "prov:hadPrimarySource", "source": "gdsc"}, {"relation_type": "prov:hadPrimarySource", "source": "go"}, {"relation_type": "prov:hadPrimarySource", "source": "gtex"}, {"relation_type": "prov:hadPrimarySource", "source": "hpa"}, {"relation_type": "prov:hadPrimarySource", "source": "huri"}, {"relation_type": "prov:hadPrimarySource", "source": "intact"}, {"relation_type": "prov:hadPrimarySource", "source": "interpro"}, {"relation_type": "prov:hadPrimarySource", "source": "lincs"}, {"relation_type": "prov:hadPrimarySource", "source": "offsides"}, {"relation_type": "prov:hadPrimarySource", "source": "omnipath"}, {"relation_type": "prov:hadPrimarySource", "source": "opentargets"}, {"relation_type": "prov:hadPrimarySource", "source": "pharmacodb"}, {"relation_type": "prov:hadPrimarySource", "source": "prism"}, {"relation_type": "prov:hadPrimarySource", "source": "progeny"}, {"relation_type": "prov:hadPrimarySource", "source": "reactome"}, {"relation_type": "prov:hadPrimarySource", "source": "repodb"}, {"relation_type": "prov:hadPrimarySource", "source": "repohub"}, {"relation_type": "prov:hadPrimarySource", "source": "sider"}, {"relation_type": "prov:hadPrimarySource", "source": "string"}, {"relation_type": "prov:hadPrimarySource", "source": "tissues"}], "product_url": "https://bioteque.irbbarcelona.org/downloads/embeddings"}], "publications": [{"authors": ["Corsello", "Bittker", "Liu", "Gould", "McCarren", "Hirschman", "Johnston", "Vrcic", "Wong", "Khan", "Asiedu", "Narayan", "Mader", "Subramanian", "Golub"], "id": "https://doi.org/10.1038/nm.4306", "journal": "Nature Medicine", "preferred": true, "title": "The Drug Repurposing Hub: a next-generation drug library and information resource", "year": "2017"}], "taxon": ["NCBITaxon:9606"]}