Vasculature Common Coordinate Framework
The Vasculature Common Coordinate Framework (VCCF) is a vasculature-based common coordinate framework that models the human blood vasculature as a branching coordinate system, using arteries, veins, and capillaries to link anatomical structures and the cells they supply or drain across organs. It is a component of the Human Reference Atlas (HRA) and is realized as the HRA-VCCF, an open, computer-readable description of the adult human blood vasculature covering vessels and their branching connections, associated cell types, and biomarkers. The VCCF underpins the "blood vasculature" ASCT+B (Anatomical Structures, Cell Types, plus Biomarkers) table and the HRA's VCCF visualization, supporting single-cell mapping and cross-organ spatial queries.
[{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://humanatlas.io/"}], "label": "HuBMAP HRA Team (Cyberinfrastructure for Network Science Center)"}]
[{"category": "GraphicalInterface", "description": "Interactive HRA Knowledge Graph Explorer view of the Vasculature Common Coordinate Framework (VCCF), browsing vessels, their branching connections, associated cell types, and biomarkers.", "format": "http", "id": "vccf.explorer", "name": "VCCF Knowledge Graph Explorer", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_url": "https://purl.humanatlas.io/vccf"}, {"category": "GraphProduct", "description": "The graph representation of the Human Reference Atlas (HRA) dataset, v2.2, Turtle format", "format": "ttl", "id": "hra-kg.graph.ttl", "name": "HRA KG graph data, v2.2, Turtle format", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "hra-kg"}, {"relation_type": "prov:hadPrimarySource", "source": "ccf"}, {"relation_type": "prov:hadPrimarySource", "source": "cl"}, {"relation_type": "prov:hadPrimarySource", "source": "fma"}, {"relation_type": "prov:hadPrimarySource", "source": "hgnc"}, {"relation_type": "prov:hadPrimarySource", "source": "hravs"}, {"relation_type": "prov:hadPrimarySource", "source": "lmha"}, {"relation_type": "prov:hadPrimarySource", "source": "pcl"}, {"relation_type": "prov:hadPrimarySource", "source": "ro"}, {"relation_type": "prov:hadPrimarySource", "source": "uberon"}, {"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_file_size": 204030087, "product_url": "https://cdn.humanatlas.io/digital-objects/collection/hra/v2.2/graph.ttl"}, {"category": "GraphProduct", "description": "The graph representation of the Human Reference Atlas (HRA) dataset, v2.2, JSON-LD format", "format": "jsonld", "id": "hra-kg.graph.json", "name": "HRA KG graph data, v2.2, JSON-LD format", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "hra-kg"}, {"relation_type": "prov:hadPrimarySource", "source": "ccf"}, {"relation_type": "prov:hadPrimarySource", "source": "cl"}, {"relation_type": "prov:hadPrimarySource", "source": "fma"}, {"relation_type": "prov:hadPrimarySource", "source": "hgnc"}, {"relation_type": "prov:hadPrimarySource", "source": "hravs"}, {"relation_type": "prov:hadPrimarySource", "source": "lmha"}, {"relation_type": "prov:hadPrimarySource", "source": "pcl"}, {"relation_type": "prov:hadPrimarySource", "source": "ro"}, {"relation_type": "prov:hadPrimarySource", "source": "uberon"}, {"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_file_size": 18043, "product_url": "https://cdn.humanatlas.io/digital-objects/collection/hra/v2.2/graph.json"}, {"category": "GraphProduct", "description": "The graph representation of the Human Reference Atlas (HRA) dataset, v2.2, RDF/XML format", "format": "rdfxml", "id": "hra-kg.graph.xml", "name": "HRA KG graph data, v2.2, RDF/XML format", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "hra-kg"}, {"relation_type": "prov:hadPrimarySource", "source": "ccf"}, {"relation_type": "prov:hadPrimarySource", "source": "cl"}, {"relation_type": "prov:hadPrimarySource", "source": "fma"}, {"relation_type": "prov:hadPrimarySource", "source": "hgnc"}, {"relation_type": "prov:hadPrimarySource", "source": "hravs"}, {"relation_type": "prov:hadPrimarySource", "source": "lmha"}, {"relation_type": "prov:hadPrimarySource", "source": "pcl"}, {"relation_type": "prov:hadPrimarySource", "source": "ro"}, {"relation_type": "prov:hadPrimarySource", "source": "uberon"}, {"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_file_size": 185060502, "product_url": "https://cdn.humanatlas.io/digital-objects/collection/hra/v2.2/graph.xml"}, {"category": "GraphProduct", "description": "The graph representation of the Human Reference Atlas (HRA) dataset, v2.2, N-Triples format", "format": "ntriples", "id": "hra-kg.graph.nt", "name": "HRA KG graph data, v2.2, N-Triples format", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "hra-kg"}, {"relation_type": "prov:hadPrimarySource", "source": "ccf"}, {"relation_type": "prov:hadPrimarySource", "source": "cl"}, {"relation_type": "prov:hadPrimarySource", "source": "fma"}, {"relation_type": "prov:hadPrimarySource", "source": "hgnc"}, {"relation_type": "prov:hadPrimarySource", "source": "hravs"}, {"relation_type": "prov:hadPrimarySource", "source": "lmha"}, {"relation_type": "prov:hadPrimarySource", "source": "pcl"}, {"relation_type": "prov:hadPrimarySource", "source": "ro"}, {"relation_type": "prov:hadPrimarySource", "source": "uberon"}, {"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_file_size": 291382102, "product_url": "https://cdn.humanatlas.io/digital-objects/collection/hra/v2.2/graph.nt"}, {"category": "GraphProduct", "description": "The graph representation of the Human Reference Atlas (HRA) dataset, v2.2, N-Quads format", "format": "nquads", "id": "hra-kg.graph.nq", "name": "HRA KG graph data, v2.2, N-Quads format", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "hra-kg"}, {"relation_type": "prov:hadPrimarySource", "source": "ccf"}, {"relation_type": "prov:hadPrimarySource", "source": "cl"}, {"relation_type": "prov:hadPrimarySource", "source": "fma"}, {"relation_type": "prov:hadPrimarySource", "source": "hgnc"}, {"relation_type": "prov:hadPrimarySource", "source": "hravs"}, {"relation_type": "prov:hadPrimarySource", "source": "lmha"}, {"relation_type": "prov:hadPrimarySource", "source": "pcl"}, {"relation_type": "prov:hadPrimarySource", "source": "ro"}, {"relation_type": "prov:hadPrimarySource", "source": "uberon"}, {"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_file_size": 376981902, "product_url": "https://cdn.humanatlas.io/digital-objects/collection/hra/v2.2/graph.nq"}]
{"activity_status": "active", "category": "Ontology", "contacts": [{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://humanatlas.io/"}], "label": "HuBMAP HRA Team (Cyberinfrastructure for Network Science Center)"}], "creation_date": "2026-06-18T00:00:00Z", "description": "The Vasculature Common Coordinate Framework (VCCF) is a vasculature-based common coordinate framework that models the human blood vasculature as a branching coordinate system, using arteries, veins, and capillaries to link anatomical structures and the cells they supply or drain across organs. It is a component of the Human Reference Atlas (HRA) and is realized as the HRA-VCCF, an open, computer-readable description of the adult human blood vasculature covering vessels and their branching connections, associated cell types, and biomarkers. The VCCF underpins the \"blood vasculature\" ASCT+B (Anatomical Structures, Cell Types, plus Biomarkers) table and the HRA's VCCF visualization, supporting single-cell mapping and cross-organ spatial queries.", "domains": ["anatomy and development", "biomedical", "biological systems"], "homepage_url": "https://purl.humanatlas.io/vccf", "id": "vccf", "last_modified_date": "2026-06-18T00:00:00Z", "layout": "resource_detail", "license": {"id": "http://creativecommons.org/licenses/by/4.0/", "label": "CC-BY-4.0", "logo": "http://mirrors.creativecommons.org/presskit/buttons/80x15/png/by.png"}, "name": "Vasculature Common Coordinate Framework", "products": [{"category": "GraphicalInterface", "description": "Interactive HRA Knowledge Graph Explorer view of the Vasculature Common Coordinate Framework (VCCF), browsing vessels, their branching connections, associated cell types, and biomarkers.", "format": "http", "id": "vccf.explorer", "name": "VCCF Knowledge Graph Explorer", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_url": "https://purl.humanatlas.io/vccf"}, {"category": "GraphProduct", "description": "The graph representation of the Human Reference Atlas (HRA) dataset, v2.2, Turtle format", "format": "ttl", "id": "hra-kg.graph.ttl", "name": "HRA KG graph data, v2.2, Turtle format", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "hra-kg"}, {"relation_type": "prov:hadPrimarySource", "source": "ccf"}, {"relation_type": "prov:hadPrimarySource", "source": "cl"}, {"relation_type": "prov:hadPrimarySource", "source": "fma"}, {"relation_type": "prov:hadPrimarySource", "source": "hgnc"}, {"relation_type": "prov:hadPrimarySource", "source": "hravs"}, {"relation_type": "prov:hadPrimarySource", "source": "lmha"}, {"relation_type": "prov:hadPrimarySource", "source": "pcl"}, {"relation_type": "prov:hadPrimarySource", "source": "ro"}, {"relation_type": "prov:hadPrimarySource", "source": "uberon"}, {"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_file_size": 204030087, "product_url": "https://cdn.humanatlas.io/digital-objects/collection/hra/v2.2/graph.ttl"}, {"category": "GraphProduct", "description": "The graph representation of the Human Reference Atlas (HRA) dataset, v2.2, JSON-LD format", "format": "jsonld", "id": "hra-kg.graph.json", "name": "HRA KG graph data, v2.2, JSON-LD format", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "hra-kg"}, {"relation_type": "prov:hadPrimarySource", "source": "ccf"}, {"relation_type": "prov:hadPrimarySource", "source": "cl"}, {"relation_type": "prov:hadPrimarySource", "source": "fma"}, {"relation_type": "prov:hadPrimarySource", "source": "hgnc"}, {"relation_type": "prov:hadPrimarySource", "source": "hravs"}, {"relation_type": "prov:hadPrimarySource", "source": "lmha"}, {"relation_type": "prov:hadPrimarySource", "source": "pcl"}, {"relation_type": "prov:hadPrimarySource", "source": "ro"}, {"relation_type": "prov:hadPrimarySource", "source": "uberon"}, {"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_file_size": 18043, "product_url": "https://cdn.humanatlas.io/digital-objects/collection/hra/v2.2/graph.json"}, {"category": "GraphProduct", "description": "The graph representation of the Human Reference Atlas (HRA) dataset, v2.2, RDF/XML format", "format": "rdfxml", "id": "hra-kg.graph.xml", "name": "HRA KG graph data, v2.2, RDF/XML format", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "hra-kg"}, {"relation_type": "prov:hadPrimarySource", "source": "ccf"}, {"relation_type": "prov:hadPrimarySource", "source": "cl"}, {"relation_type": "prov:hadPrimarySource", "source": "fma"}, {"relation_type": "prov:hadPrimarySource", "source": "hgnc"}, {"relation_type": "prov:hadPrimarySource", "source": "hravs"}, {"relation_type": "prov:hadPrimarySource", "source": "lmha"}, {"relation_type": "prov:hadPrimarySource", "source": "pcl"}, {"relation_type": "prov:hadPrimarySource", "source": "ro"}, {"relation_type": "prov:hadPrimarySource", "source": "uberon"}, {"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_file_size": 185060502, "product_url": "https://cdn.humanatlas.io/digital-objects/collection/hra/v2.2/graph.xml"}, {"category": "GraphProduct", "description": "The graph representation of the Human Reference Atlas (HRA) dataset, v2.2, N-Triples format", "format": "ntriples", "id": "hra-kg.graph.nt", "name": "HRA KG graph data, v2.2, N-Triples format", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "hra-kg"}, {"relation_type": "prov:hadPrimarySource", "source": "ccf"}, {"relation_type": "prov:hadPrimarySource", "source": "cl"}, {"relation_type": "prov:hadPrimarySource", "source": "fma"}, {"relation_type": "prov:hadPrimarySource", "source": "hgnc"}, {"relation_type": "prov:hadPrimarySource", "source": "hravs"}, {"relation_type": "prov:hadPrimarySource", "source": "lmha"}, {"relation_type": "prov:hadPrimarySource", "source": "pcl"}, {"relation_type": "prov:hadPrimarySource", "source": "ro"}, {"relation_type": "prov:hadPrimarySource", "source": "uberon"}, {"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_file_size": 291382102, "product_url": "https://cdn.humanatlas.io/digital-objects/collection/hra/v2.2/graph.nt"}, {"category": "GraphProduct", "description": "The graph representation of the Human Reference Atlas (HRA) dataset, v2.2, N-Quads format", "format": "nquads", "id": "hra-kg.graph.nq", "name": "HRA KG graph data, v2.2, N-Quads format", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "hra-kg"}, {"relation_type": "prov:hadPrimarySource", "source": "ccf"}, {"relation_type": "prov:hadPrimarySource", "source": "cl"}, {"relation_type": "prov:hadPrimarySource", "source": "fma"}, {"relation_type": "prov:hadPrimarySource", "source": "hgnc"}, {"relation_type": "prov:hadPrimarySource", "source": "hravs"}, {"relation_type": "prov:hadPrimarySource", "source": "lmha"}, {"relation_type": "prov:hadPrimarySource", "source": "pcl"}, {"relation_type": "prov:hadPrimarySource", "source": "ro"}, {"relation_type": "prov:hadPrimarySource", "source": "uberon"}, {"relation_type": "prov:hadPrimarySource", "source": "vccf"}], "product_file_size": 376981902, "product_url": "https://cdn.humanatlas.io/digital-objects/collection/hra/v2.2/graph.nq"}], "publications": [{"authors": ["Avinash Boppana", "Sujin Lee", "Rajeev Malhotra", "Marc Halushka", "Katherine S Gustilo", "Ellen M. Quardokus", "Bruce W. Herr II", "Katy B\u00f6rner", "Griffin M. Weber"], "doi": "10.1038/s41597-023-02018-0", "id": "https://doi.org/10.1038/s41597-023-02018-0", "journal": "Scientific Data", "title": "Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature", "year": "2023"}]}