Human Reference Protein Interactome Mapping Project
The Human Reference Protein Interactome Mapping Project (HRPIMP) is a systematic effort to map binary protein-protein interactions in human cells. The project produced the Human Reference Interactome (HuRI) database containing high-quality experimentally validated protein-protein interactions. Using systematic yeast two-hybrid (Y2H) screening approaches, HRPIMP produced proteome-scale human PPI datasets including HuRI, HI-union, and earlier CCSB interactome screens. The current HuRI portal provides the HuRI dataset with 52,569 interactions in TSV and PSI-MI formats, mapped to Ensembl identifiers for GENCODE protein-coding genes.
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["Luck K", "Kim DK", "Lambourne L", "Spirohn K", "Begg BE", "Bian W", "Brignall R", "Cafarelli T", "Campos-Laborie FJ", "Charloteaux B", "Choi D", "Cot\u00e9 AG", "Daley M", "Deimling S", "Desbuleux A", "Dricot A", "Gebbia M", "Hardy MF", "Kishore N", "Knapp JJ", "Kov\u00e1cs IA", "Lemmens I", "Mee MW", "Mellor JC", "Pollis C", "Pons C", "Richardson AD", "Schlabach S", "Teeking B", "Yadav A", "Babor M", "Balcha D", "Basha O", "Bowman-Colin C", "Chin SF", "Choi SG", "Colabella C", "Coppin G", "D'Amata C", "De Ridder D", "De Rouck S", "Duran-Frigola M", "Ennajdaoui H", "Goebels F", "Goehring L", "Gopal A", "Haddad G", "Hatchi E", "Helmy M", "Jacob Y", "Kassa Y", "Landini S", "Li R", "van Lieshout N", "MacWilliams A", "Markey D", "Paulson JN", "Rangarajan S", "Rasla J", "Rayhan A", "Rolland T", "San-Miguel A", "Shen Y", "Sheykhkarimli D", "Sheynkman GM", "Simonovsky E", "Ta\u015fan M", "Tejeda A", "Tropepe V", "Twizere JC", "Wang Y", "Weatheritt RJ", "Weile J", "Xia Y", "Yang X", "Yeger-Lotem E", "Zhong Q", "Aloy P", "Bader GD", "De Las Rivas J", "Gaudet S", "Hao T", "Rak J", "Tavernier J", "Hill DE", "Vidal M", "Roth FP", "Calderwood MA"], "doi": "10.1038/s41586-020-2188-x", "id": "doi:10.1038/s41586-020-2188-x", "journal": "Nature", "preferred": true, "title": "A reference map of the human binary protein interactome", "year": "2020"}], "repository": "https://github.com/CCSB-DFCI/HuRI_paper", "synonyms": ["HRPIMP", "HuRI", "Human Reference Interactome"], "taxon": ["NCBITaxon:9606"]}