Common Coordinate Framework Ontology
The Common Coordinate Framework (CCF) Ontology is the spatial and semantic framework that underpins the Human Reference Atlas (HRA) developed within the NIH Human BioMolecular Atlas Program (HuBMAP). It encodes the relationships among anatomical structures, cell types, and biomarkers captured in the ASCT+B (Anatomical Structures, Cell Types, plus Biomarkers) tables, linking them to established ontologies such as Uberon, FMA, and Cell Ontology. The CCF also provides a spatial component that supports 3D spatial registration of tissue samples to reference organs via the CCF Registration User Interface, giving each sample a defined location in a common coordinate system. Together these clinical, semantic, and spatial layers serve as a primary upstream source for the HRA Knowledge Graph (HRA-KG).
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