name: GeneMANIA
description: GeneMANIA is a gene function prediction resource that integrates many types of functional association networks (co-expression, protein and genetic interactions, pathways, co-localization, and shared protein domains) and uses adaptive network weighting with label propagation to prioritize related genes and expand gene lists.
contacts: []
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raw_data: {"activity_status": "active", "category": "DataSource", "creation_date": "2025-08-20T00:00:00Z", "description": "GeneMANIA is a gene function prediction resource that integrates many types of functional association networks (co-expression, protein and genetic interactions, pathways, co-localization, and shared protein domains) and uses adaptive network weighting with label propagation to prioritize related genes and expand gene lists.", "domains": ["genomics", "biomedical", "proteomics"], "homepage_url": "https://genemania.org/", "id": "genemania", "last_modified_date": "2025-08-20T00:00:00Z", "layout": "resource_detail", "name": "GeneMANIA", "products": [{"category": "GraphicalInterface", "description": "Web interface for searching, visualizing, and analyzing functional association networks", "id": "genemania.web", "name": "GeneMANIA Web Interface", "product_url": "https://genemania.org/"}, {"category": "GraphProduct", "description": "PheKnowLator graph files, including subsets with and without inverse relations.", "format": "owl", "id": "pheknowlator.graph", "latest_version": "current_build", "name": "PheKnowLator graph", "original_source": ["cl", "clo", "chebi", "go", "hp", "mondo", "pw", "pr", "ro", "so", "uberon", "vo", "bioportal", "clinvar", "ctd", "disgenet", "ensembl", "genemania", "hgnc", "hpa", "ncbigene", "medgen", "reactome", "string", "uniprot"], "product_url": "https://console.cloud.google.com/storage/browser/pheknowlator/current_build/knowledge_graphs?pageState=(%22StorageObjectListTable%22:(%22f%22:%22%255B%255D%22))&inv=1&invt=Ab5_1Q&project=pheknowlator", "secondary_source": ["pheknowlator"], "versions": ["v1.0.0", "v2.0.0", "v2.1.0", "v3.0.2", "v4.0.0", "current_build"]}], "publications": [{"authors": ["Warde-Farley D", "Donaldson SL", "Comes O", "Zuberi K", "Badrawi R", "et al."], "doi": "10.1093/nar/gkq537", "id": "doi:10.1093/nar/gkq537", "journal": "Nucleic Acids Research", "preferred": true, "title": "The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function", "year": "2010"}], "usages": [{"description": "The PheKnowLator knowledge graph ingests GeneMANIA functional association networks to construct gene-to-gene associations (e.g., co-expression and interaction edges) during its build.", "id": "pheknowlator-gene-gene-edges", "label": "PheKnowLator gene\u2013gene edges", "type": "actual", "url": "https://github.com/callahantiff/PheKnowLator/wiki"}]}