CREEDS
CREEDS (CRowd Extracted Expression of Differential Signatures) is a database of crowdsourced gene expression signatures for drug, genetic, and disease perturbations.
[{"category": "Individual", "contact_details": [{"contact_type": "email", "value": "avi.maayan@mssm.edu"}, {"contact_type": "github", "value": "MaayanLab"}], "label": "Avi Ma'ayan", "orcid": "0000-0002-6628-6249"}]
[{"category": "Product", "description": "Network embeddings of the Bioteque graph that represent biological entities and their associations", "format": "mixed", "id": "bioteque.embeddings", "name": "Bioteque Embeddings", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "achilles"}, {"relation_type": "prov:hadPrimarySource", "source": "bioteque"}, {"relation_type": "prov:hadPrimarySource", "source": "bto"}, {"relation_type": "prov:hadPrimarySource", "source": "ccle"}, {"relation_type": "prov:hadPrimarySource", "source": "cellosaurus"}, {"relation_type": "prov:hadPrimarySource", "source": "chebi"}, {"relation_type": "prov:hadPrimarySource", "source": "chemicalchecker"}, {"relation_type": "prov:hadPrimarySource", "source": "clue"}, {"relation_type": "prov:hadPrimarySource", "source": "compartments"}, {"relation_type": "prov:hadPrimarySource", "source": "corum"}, {"relation_type": "prov:hadPrimarySource", "source": "cosmic"}, {"relation_type": "prov:hadPrimarySource", "source": "creeds"}, {"relation_type": "prov:hadPrimarySource", "source": "ctd"}, {"relation_type": "prov:hadPrimarySource", "source": "depmap"}, {"relation_type": "prov:hadPrimarySource", "source": "disgenet"}, {"relation_type": "prov:hadPrimarySource", "source": "dorothea"}, {"relation_type": "prov:hadPrimarySource", "source": "drugbank"}, {"relation_type": "prov:hadPrimarySource", "source": "drugcentral"}, {"relation_type": "prov:hadPrimarySource", "source": "gdsc"}, {"relation_type": "prov:hadPrimarySource", "source": "go"}, {"relation_type": "prov:hadPrimarySource", "source": "gtex"}, {"relation_type": "prov:hadPrimarySource", "source": "hpa"}, {"relation_type": "prov:hadPrimarySource", "source": "huri"}, {"relation_type": "prov:hadPrimarySource", "source": "intact"}, {"relation_type": "prov:hadPrimarySource", "source": "interpro"}, {"relation_type": "prov:hadPrimarySource", "source": "lincs"}, {"relation_type": "prov:hadPrimarySource", "source": "offsides"}, {"relation_type": "prov:hadPrimarySource", "source": "omnipath"}, {"relation_type": "prov:hadPrimarySource", "source": "opentargets"}, {"relation_type": "prov:hadPrimarySource", "source": "pharmacodb"}, {"relation_type": "prov:hadPrimarySource", "source": "prism"}, {"relation_type": "prov:hadPrimarySource", "source": "progeny"}, {"relation_type": "prov:hadPrimarySource", "source": "reactome"}, {"relation_type": "prov:hadPrimarySource", "source": "repodb"}, {"relation_type": "prov:hadPrimarySource", "source": "repohub"}, {"relation_type": "prov:hadPrimarySource", "source": "sider"}, {"relation_type": "prov:hadPrimarySource", "source": "string"}, {"relation_type": "prov:hadPrimarySource", "source": "tissues"}], "product_url": "https://bioteque.irbbarcelona.org/downloads/embeddings"}, {"category": "Product", "description": "Manual gene expression signatures derived from single gene perturbations", "format": "json", "id": "creeds.manual_single_gene", "name": "CREEDS Manual Single Gene Perturbations", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 58276121, "product_url": "https://maayanlab.cloud/CREEDS/download/single_gene_perturbations-v1.0.json"}, {"category": "Product", "description": "Manual gene expression signatures derived from disease signatures", "format": "json", "id": "creeds.manual_disease_signatures", "name": "CREEDS Manual Disease Signatures", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 16865407, "product_url": "https://maayanlab.cloud/CREEDS/download/disease_signatures-v1.0.json"}, {"category": "Product", "description": "Manual gene expression signatures derived single drug perturbations", "format": "json", "id": "creeds.manual_single_drug", "name": "CREEDS Manual Single Drug Perturbations", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 17836091, "product_url": "https://maayanlab.cloud/CREEDS/download/single_drug_perturbations-v1.0.json"}, {"category": "Product", "description": "DrugMatrix single drug perturbations", "format": "json", "id": "creeds.drugmatrix", "name": "CREEDS DrugMatrix single drug perturbations", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 86943390, "product_url": "https://maayanlab.cloud/CREEDS/download/single_drug_perturbations-DM.json"}, {"category": "Product", "description": "Automatic gene expression signatures derived from single gene perturbations", "format": "json", "id": "creeds.automatic_single_gene", "name": "CREEDS Automatic Single Gene Perturbations", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 175552254, "product_url": "https://maayanlab.cloud/CREEDS/download/single_gene_perturbations-p1.0.json"}, {"category": "Product", "description": "Automatic gene expression signatures derived from disease signatures", "format": "json", "id": "creeds.automatic_disease_signatures", "name": "CREEDS Automatic Disease Signatures", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 29173111, "product_url": "https://maayanlab.cloud/CREEDS/download/disease_signatures-p1.0.json"}, {"category": "Product", "description": "Automatic gene expression signatures derived from single drug perturbations", "format": "json", "id": "creeds.automatic_single_drug", "name": "CREEDS Automatic Single Drug Perturbations", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 87060413, "product_url": "https://maayanlab.cloud/CREEDS/download/single_drug_perturbations-p1.0.json"}, {"category": "GraphicalInterface", "description": "Web interface for exploring CREEDS gene expression signatures", "format": "http", "id": "creeds.web_interface", "name": "CREEDS Web Interface", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_url": "https://maayanlab.cloud/CREEDS/"}]
{"activity_status": "active", "category": "DataSource", "contacts": [{"category": "Individual", "contact_details": [{"contact_type": "email", "value": "avi.maayan@mssm.edu"}, {"contact_type": "github", "value": "MaayanLab"}], "label": "Avi Ma'ayan", "orcid": "0000-0002-6628-6249"}], "creation_date": "2025-07-08T00:00:00Z", "description": "CREEDS (CRowd Extracted Expression of Differential Signatures) is a database of crowdsourced gene expression signatures for drug, genetic, and disease perturbations.", "domains": ["pharmacology", "genomics"], "id": "creeds", "last_modified_date": "2026-06-18T00:00:00Z", "layout": "resource_detail", "license": {"id": "https://creativecommons.org/licenses/by/4.0/", "label": "CC-BY-4.0", "logo": "http://mirrors.creativecommons.org/presskit/buttons/80x15/png/by.png"}, "name": "CREEDS", "products": [{"category": "Product", "description": "Network embeddings of the Bioteque graph that represent biological entities and their associations", "format": "mixed", "id": "bioteque.embeddings", "name": "Bioteque Embeddings", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "achilles"}, {"relation_type": "prov:hadPrimarySource", "source": "bioteque"}, {"relation_type": "prov:hadPrimarySource", "source": "bto"}, {"relation_type": "prov:hadPrimarySource", "source": "ccle"}, {"relation_type": "prov:hadPrimarySource", "source": "cellosaurus"}, {"relation_type": "prov:hadPrimarySource", "source": "chebi"}, {"relation_type": "prov:hadPrimarySource", "source": "chemicalchecker"}, {"relation_type": "prov:hadPrimarySource", "source": "clue"}, {"relation_type": "prov:hadPrimarySource", "source": "compartments"}, {"relation_type": "prov:hadPrimarySource", "source": "corum"}, {"relation_type": "prov:hadPrimarySource", "source": "cosmic"}, {"relation_type": "prov:hadPrimarySource", "source": "creeds"}, {"relation_type": "prov:hadPrimarySource", "source": "ctd"}, {"relation_type": "prov:hadPrimarySource", "source": "depmap"}, {"relation_type": "prov:hadPrimarySource", "source": "disgenet"}, {"relation_type": "prov:hadPrimarySource", "source": "dorothea"}, {"relation_type": "prov:hadPrimarySource", "source": "drugbank"}, {"relation_type": "prov:hadPrimarySource", "source": "drugcentral"}, {"relation_type": "prov:hadPrimarySource", "source": "gdsc"}, {"relation_type": "prov:hadPrimarySource", "source": "go"}, {"relation_type": "prov:hadPrimarySource", "source": "gtex"}, {"relation_type": "prov:hadPrimarySource", "source": "hpa"}, {"relation_type": "prov:hadPrimarySource", "source": "huri"}, {"relation_type": "prov:hadPrimarySource", "source": "intact"}, {"relation_type": "prov:hadPrimarySource", "source": "interpro"}, {"relation_type": "prov:hadPrimarySource", "source": "lincs"}, {"relation_type": "prov:hadPrimarySource", "source": "offsides"}, {"relation_type": "prov:hadPrimarySource", "source": "omnipath"}, {"relation_type": "prov:hadPrimarySource", "source": "opentargets"}, {"relation_type": "prov:hadPrimarySource", "source": "pharmacodb"}, {"relation_type": "prov:hadPrimarySource", "source": "prism"}, {"relation_type": "prov:hadPrimarySource", "source": "progeny"}, {"relation_type": "prov:hadPrimarySource", "source": "reactome"}, {"relation_type": "prov:hadPrimarySource", "source": "repodb"}, {"relation_type": "prov:hadPrimarySource", "source": "repohub"}, {"relation_type": "prov:hadPrimarySource", "source": "sider"}, {"relation_type": "prov:hadPrimarySource", "source": "string"}, {"relation_type": "prov:hadPrimarySource", "source": "tissues"}], "product_url": "https://bioteque.irbbarcelona.org/downloads/embeddings"}, {"category": "Product", "description": "Manual gene expression signatures derived from single gene perturbations", "format": "json", "id": "creeds.manual_single_gene", "name": "CREEDS Manual Single Gene Perturbations", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 58276121, "product_url": "https://maayanlab.cloud/CREEDS/download/single_gene_perturbations-v1.0.json"}, {"category": "Product", "description": "Manual gene expression signatures derived from disease signatures", "format": "json", "id": "creeds.manual_disease_signatures", "name": "CREEDS Manual Disease Signatures", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 16865407, "product_url": "https://maayanlab.cloud/CREEDS/download/disease_signatures-v1.0.json"}, {"category": "Product", "description": "Manual gene expression signatures derived single drug perturbations", "format": "json", "id": "creeds.manual_single_drug", "name": "CREEDS Manual Single Drug Perturbations", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 17836091, "product_url": "https://maayanlab.cloud/CREEDS/download/single_drug_perturbations-v1.0.json"}, {"category": "Product", "description": "DrugMatrix single drug perturbations", "format": "json", "id": "creeds.drugmatrix", "name": "CREEDS DrugMatrix single drug perturbations", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 86943390, "product_url": "https://maayanlab.cloud/CREEDS/download/single_drug_perturbations-DM.json"}, {"category": "Product", "description": "Automatic gene expression signatures derived from single gene perturbations", "format": "json", "id": "creeds.automatic_single_gene", "name": "CREEDS Automatic Single Gene Perturbations", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 175552254, "product_url": "https://maayanlab.cloud/CREEDS/download/single_gene_perturbations-p1.0.json"}, {"category": "Product", "description": "Automatic gene expression signatures derived from disease signatures", "format": "json", "id": "creeds.automatic_disease_signatures", "name": "CREEDS Automatic Disease Signatures", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 29173111, "product_url": "https://maayanlab.cloud/CREEDS/download/disease_signatures-p1.0.json"}, {"category": "Product", "description": "Automatic gene expression signatures derived from single drug perturbations", "format": "json", "id": "creeds.automatic_single_drug", "name": "CREEDS Automatic Single Drug Perturbations", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_file_size": 87060413, "product_url": "https://maayanlab.cloud/CREEDS/download/single_drug_perturbations-p1.0.json"}, {"category": "GraphicalInterface", "description": "Web interface for exploring CREEDS gene expression signatures", "format": "http", "id": "creeds.web_interface", "name": "CREEDS Web Interface", "original_source": [{"relation_type": "prov:hadPrimarySource", "source": "creeds"}], "product_url": "https://maayanlab.cloud/CREEDS/"}], "publications": [{"authors": ["Zichen Wang", "Caroline D. Monteiro", "Kathleen M. Jagodnik", "Nicolas F. Fernandez", "Gregory W. Gundersen", "Andrew D. Rouillard", "Sherry L. Jenkins", "Axel S. Feldmann", "Kevin S. Hu", "Michael G. McDermott", "Qiaonan Duan", "Neil R. Clark", "Matthew R. Jones", "Yan Kou", "Troy Goff", "Holly Woodland", "Fabio M R. Amaral", "Gregory L. Szeto", "Oliver Fuchs", "Sophia M. Sch\u00fcssler-Fiorenza Rose", "Shvetank Sharma", "Uwe Schwartz", "Xabier Bengoetxea Bausela", "Maciej Szymkiewicz", "Vasileios Maroulis", "Anton Salykin", "Carolina M. Barra", "Candice D. Kruth", "Nicholas J. Bongio", "Vaibhav Mathur", "Radmila D Todoric", "Udi E. Rubin", "Apostolos Malatras", "Carl T. Fulp", "John A. Galindo", "Ruta Motiejunaite", "Christoph J\u00fcschke", "Philip C. Dishuck", "Katharina Lahl", "Mohieddin Jafari", "Sara Aibar", "Apostolos Zaravinos", "Linda H. Steenhuizen", "Lindsey R. Allison", "Pablo Gamallo", "Fernando de Andres Segura", "Tyler Dae Devlin", "Vicente P\u00e9rez-Garc\u00eda", "Avi Ma\u2019ayan"], "doi": "10.1038/ncomms12846", "id": "doi:10.1038/ncomms12846", "journal": "Nature Communications", "title": "Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd", "year": "2016"}]}