name: CLUE
description: CLUE (formerly known as the Connectivity Map or CMap 2.0) is a comprehensive resource for connecting drugs, genes, and diseases through large-scale perturbational data. Built and maintained by the Broad Institute, CLUE provides access to over 1.3 million gene expression profiles from the LINCS L1000 assay, covering more than 42,000 perturbagens (drugs, genetic reagents, and other compounds) tested across multiple cell lines. The platform enables researchers to discover connections between diseases, drugs, and biological mechanisms through gene expression signatures.
contacts: [{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://clue.io/about"}], "label": "Broad Institute of MIT and Harvard"}]
products: [{"category": "Product", "description": "Network embeddings of the Bioteque graph that represent biological entities and their associations", "id": "bioteque.embeddings", "name": "Bioteque Embeddings", "original_source": ["chebi", "cosmic", "achilles", "depmap", "ccle", "gdsc", "cellosaurus", "clue", "ctd", "pharmacodb", "prism", "drugbank", "lincs", "compartments", "offsides", "sider", "drugcentral", "repohub", "chemicalchecker", "repodb", "disgenet", "opentargets", "creeds", "interpro", "reactome", "tissues", "dorothea", "progeny", "gtex", "hpa", "go", "corum", "huri", "intact", "omnipath", "string", "bto"], "product_url": "https://bioteque.irbbarcelona.org/downloads/embeddings", "secondary_source": ["bioteque"]}]
raw_data: {"activity_status": "active", "category": "DataSource", "contacts": [{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://clue.io/about"}], "label": "Broad Institute of MIT and Harvard"}], "creation_date": "2025-08-12T00:00:00Z", "description": "CLUE (formerly known as the Connectivity Map or CMap 2.0) is a comprehensive resource for connecting drugs, genes, and diseases through large-scale perturbational data. Built and maintained by the Broad Institute, CLUE provides access to over 1.3 million gene expression profiles from the LINCS L1000 assay, covering more than 42,000 perturbagens (drugs, genetic reagents, and other compounds) tested across multiple cell lines. The platform enables researchers to discover connections between diseases, drugs, and biological mechanisms through gene expression signatures.", "domains": ["drug discovery", "genomics", "biomedical", "systems biology"], "homepage_url": "https://clue.io/", "id": "clue", "last_modified_date": "2025-10-07T00:00:00Z", "layout": "resource_detail", "name": "CLUE", "products": [{"category": "Product", "description": "Network embeddings of the Bioteque graph that represent biological entities and their associations", "id": "bioteque.embeddings", "name": "Bioteque Embeddings", "original_source": ["chebi", "cosmic", "achilles", "depmap", "ccle", "gdsc", "cellosaurus", "clue", "ctd", "pharmacodb", "prism", "drugbank", "lincs", "compartments", "offsides", "sider", "drugcentral", "repohub", "chemicalchecker", "repodb", "disgenet", "opentargets", "creeds", "interpro", "reactome", "tissues", "dorothea", "progeny", "gtex", "hpa", "go", "corum", "huri", "intact", "omnipath", "string", "bto"], "product_url": "https://bioteque.irbbarcelona.org/downloads/embeddings", "secondary_source": ["bioteque"]}], "repository": "https://github.com/cmap"}