Drug Repurposing Hub
Curated collection of approved, clinical, and pre-clinical compounds with detailed annotations and sample metadata to support drug repurposing screens and analyses.
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{"activity_status": "active", "category": "DataSource", "contacts": [{"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://www.broadinstitute.org/center-development-therapeutics-cdot"}], "id": "broad-cdot", "label": "Broad Institute Center for the Development of Therapeutics (CDoT)"}, {"category": "Organization", "contact_details": [{"contact_type": "url", "value": "https://www.broadinstitute.org/"}], "id": "broad-institute", "label": "Broad Institute"}], "creation_date": "2026-01-22T00:00:00Z", "description": "Curated collection of approved, clinical, and pre-clinical compounds with detailed annotations and sample metadata to support drug repurposing screens and analyses.", "domains": ["drug discovery", "pharmacology", "biomedical"], "homepage_url": "https://repo-hub.broadinstitute.org/repurposing", "id": "drugrephub", "last_modified_date": "2026-01-22T00:00:00Z", "layout": "resource_detail", "name": "Drug Repurposing Hub", "products": [{"category": "Product", "description": "Latest drug-level annotations including compound names, clinical phase, mechanism of action, and protein targets (listed as version 2025-08-19 on the site).", "format": "tsv", "id": "drugrephub.drug-info.tsv", "name": "Drug Repurposing Hub Drug Information TSV", "product_url": "https://repo-hub.broadinstitute.org/public/data/repo-drug-annotation-20200324.txt", "warnings": ["File was not able to be retrieved when checked on 2026-01-30_ Error connecting to URL_ HTTPSConnectionPool(host='repo-hub.broadinstitute.org', port=443)_ Max retries exceeded with url_ /public/data/repo-drug-annotation-20200324.txt (Caused by SSLError(SSLCertVerificationError(1, '[SSL_ CERTIFICATE_VERIFY_FAILED] certificate verify failed_ unable to get local issuer certificate (_ssl.c_1000)')))", "File was not able to be retrieved when checked on 2026-01-28_ Error connecting to URL_ HTTPSConnectionPool(host='repo-hub.broadinstitute.org', port=443)_ Max retries exceeded with url_ /public/data/repo-drug-annotation-20200324.txt (Caused by SSLError(SSLCertVerificationError(1, '[SSL_ CERTIFICATE_VERIFY_FAILED] certificate verify failed_ unable to get local issuer certificate (_ssl.c_1000)')))", "File was not able to be retrieved when checked on 2026-02-04: Error connecting to URL: HTTPSConnectionPool(host='repo-hub.broadinstitute.org', port=443): Max retries exceeded with url: /public/data/repo-drug-annotation-20200324.txt (Caused by SSLError(SSLCertVerificationError(1, '[SSL: CERTIFICATE_VERIFY_FAILED] certificate verify failed: unable to get local issuer certificate (_ssl.c:1000)')))"]}, {"category": "Product", "description": "Latest physical sample-level metadata including Broad sample IDs, vendor catalog numbers, SMILES, InChIKey, and PubChem IDs (listed as version 2025-08-19 on the site).", "format": "tsv", "id": "drugrephub.sample-info.tsv", "name": "Drug Repurposing Hub Sample Information TSV", "product_url": "https://repo-hub.broadinstitute.org/public/data/repo-sample-annotation-20240610.txt", "warnings": ["File was not able to be retrieved when checked on 2026-01-30_ Error connecting to URL_ HTTPSConnectionPool(host='repo-hub.broadinstitute.org', port=443)_ Max retries exceeded with url_ /public/data/repo-sample-annotation-20240610.txt (Caused by SSLError(SSLCertVerificationError(1, '[SSL_ CERTIFICATE_VERIFY_FAILED] certificate verify failed_ unable to get local issuer certificate (_ssl.c_1000)')))", "File was not able to be retrieved when checked on 2026-01-28_ Error connecting to URL_ HTTPSConnectionPool(host='repo-hub.broadinstitute.org', port=443)_ Max retries exceeded with url_ /public/data/repo-sample-annotation-20240610.txt (Caused by SSLError(SSLCertVerificationError(1, '[SSL_ CERTIFICATE_VERIFY_FAILED] certificate verify failed_ unable to get local issuer certificate (_ssl.c_1000)')))", "File was not able to be retrieved when checked on 2026-02-04: Error connecting to URL: HTTPSConnectionPool(host='repo-hub.broadinstitute.org', port=443): Max retries exceeded with url: /public/data/repo-sample-annotation-20240610.txt (Caused by SSLError(SSLCertVerificationError(1, '[SSL: CERTIFICATE_VERIFY_FAILED] certificate verify failed: unable to get local issuer certificate (_ssl.c:1000)')))"]}, {"category": "GraphProduct", "description": "KGX graph package for Drug Repurposing Hub (build drug_rep_hub_2025-08-19_1.0_2025sep1_4.3.6; release 2025_12_15)", "format": "kgx", "id": "translator.drug_rep_hub.graph", "name": "Translator Drug Repurposing Hub KGX Graph", "original_source": ["drugrephub"], "product_url": "https://stars.renci.org/var/translator/releases/drug_rep_hub/2025_12_15/", "secondary_source": ["translator"]}]}