is a Data Source.
It is part of the BER collection.
SIGNOR (SIGnaling Network Open Resource) is a manually curated repository of experimentally supported, causal relationships between human proteins and other biologically relevant entities (chemicals, phenotypes, complexes, families, stimuli). Each interaction is annotated with effect, mechanism, directionality, evidence (PMID), and a relevance score, enabling construction and analysis of signed, directed signaling networks and pathways. Cite SIGNOR (Lo Surdo et al., 2022 NAR) when using data; interaction data are directional and signed—verify effect/mechanism fields when integrating.
pathways, biomedical, systems biology, proteomics
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infores:signor
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| signor.web | SIGNOR Website | signor.uniroma2.it | GraphicalInterface | http | Web interface for browsing entities, ... |
| signor.api | SIGNOR REST API | APIs.php | ProgrammingInterface | http | REST-style endpoints for retrieving i... |
| signor.complete | SIGNOR Latest Stable Release | getLatestRelease.php | GraphProduct | tsv | Latest stable SIGNOR complete dataset... |
| signor.interactions.dynamic | SIGNOR Interaction Query Endpoint | getData.php | ProgrammingInterface | tsv | Programmatic interaction data query r... |
| signor.pathways | SIGNOR Pathway Data | getPathwayData.php | ProgrammingInterface | tsv | Pathway data (entities and relations)... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| clinicalkg.graph | CKG Graph Dump | 1 | GraphProduct | mixed | had primary source | Neo4j database dump of the Clinical K... |
| cancer-genome-interpreter.clinicalkg.graph | CKG Graph Dump | 1 | GraphProduct | mixed | had primary source | Neo4j database dump of the Clinical K... |
| translator.signor.graph | Translator SIGNOR KGX Graph | latest | GraphProduct | kgx-jsonl | had primary source | KGX JSONL graph package for SIGNOR di... |
| obo-db-ingest.signor.tsv | signor Nodes TSV | signor.tsv (28.7 KB) | Product | tsv | had primary source | signor Nodes TSV |
| translator.translator_kg.graph | Translator Aggregate KGX Graph | latest | GraphProduct | kgx-jsonl | had primary source | Aggregated KGX JSONL graph package co... |
| ckg.graph | CKG Graph Database Dump | 1 | GraphProduct | neo4j | had primary source | Graph database dump and additional re... |
SIGNOR (SIGnaling Network Open Resource) is a curated knowledgebase capturing causally directed, signed interactions underlying human cellular signaling. Interactions link proteins and other entities (chemicals, stimuli, phenotypes, complexes, families) with effect, mechanism, residue context when available, evidence (PMIDs), and a relevance score. Data can be accessed via the web UI, downloadable latest stable release, and granular REST endpoints (getData.php, getPathwayData.php, and others for complexes and human-only subsets). Use CC-BY 4.0 licensed data with appropriate citation (Lo Surdo et al., 2022). When integrating, preserve directionality and sign to enable pathway and network inference.
Created: August 12, 2025 | Last modified: August 23, 2025