is a Knowledge Graph.
It is part of the AOP collection.
AOP-Wiki RDF is an RDF representation of the AOP-Wiki, the authoring interface of the Adverse Outcome Pathway Knowledge Base. The AOP-Wiki XML export is converted to RDF/Turtle every week using the AOP Ontology (aopo) together with Dublin Core, CHEMINF and NCIT, and is enriched with gene mappings (gene names in key events matched to HGNC symbols and resolved to Ensembl, NCBI Gene, UniProt and Protein Ontology identifiers through BridgeDb) and chemical cross-references. AOPs, key events, key event relationships, biological events, stressors and chemicals get identifiers.org URIs and are linked to ChEBI, GO, PATO, UBERON, CL, NCBITaxon and HGNC. The 2026.08.15 release has about 340,000 triples, covering 595 AOPs, 1,595 key events, 2,360 key event relationships, 754 stressors and 430 chemicals. The data is served from a public SPARQL endpoint with a SNORQL query interface on top of it. A grlc REST API built from the same curated query library, a second endpoint holding every quarterly AOP-Wiki snapshot since 2018 as named graphs, and a dashboard for version-over-version trends are also available.
toxicology, environment, pathways, chemistry and biochemistry
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| aopwiki-rdf.sparql | AOP-Wiki RDF SPARQL Endpoint | sparql | ProgrammingInterface | http | Public SPARQL 1.1 endpoint (Virtuoso ... |
| aopwiki-rdf.snorql | AOP-Wiki RDF SNORQL Interface | aopwiki.rdf.bigcat-bioinformatics.org | GraphicalInterface | http | SNORQL web interface ("AOP-Wiki RDF E... |
| aopwiki-rdf.ttl | AOP-Wiki RDF Turtle Dataset | data | GraphProduct | ttl | The AOP-Wiki RDF dataset in RDF/Turtl... |
| aopwiki-rdf.void | AOP-Wiki RDF VoID Description | AOPWikiRDF-Void.ttl (1.0 KB) | Product | ttl | VoID metadata describing the AOP-Wiki... |
| aopwiki-rdf.converter | AOP-Wiki XML to RDF Conversion Tool | AOPWikiRDF | ProcessProduct | http | Python conversion pipeline that trans... |
| aopwiki-rdf.multiversion-sparql | AOP-Wiki RDF Multi-Version SPARQL Endpoint | sparql | ProgrammingInterface | http | Companion SPARQL endpoint holding eve... |
| aopwiki-rdf.dashboard | AOP-Wiki RDF Dashboard | aopwiki-dashboard.vhp4safety.nl | GraphicalInterface | http | Web dashboard visualizing the content... |
| aopwiki-rdf.grlc-api | AOP-Wiki RDF grlc REST API | aopwiki.api.bigcat-bioinformatics.org | ProgrammingInterface | http | grlc-generated REST API that exposes ... |
| aopwiki-rdf.queries | AOP-Wiki SPARQL Query Library | AOP-Wiki-Queries | DocumentationProduct | http | Curated library of documented SPARQL ... |
AOP-Wiki RDF is a semantic web representation of the AOP-Wiki, the community authoring and curation interface of the Adverse Outcome Pathway Knowledge Base (AOP-KB). The weekly AOP-Wiki XML export is converted to RDF/Turtle using the AOP Ontology (aopo) alongside Dublin Core, CHEMINF and NCIT, making the mechanistic toxicology content of the AOP-Wiki queryable with SPARQL.
The 2026.08.15 release contains roughly 340,000 triples across three Turtle files that are loaded together as a single dataset:
AOPWikiRDF.ttl — triples derived directly from the AOP-Wiki XML exportAOPWikiRDF-Genes.ttl — gene mapping enrichmentAOPWikiRDF-Enriched.ttl — chemical and protein cross-reference enrichmentThis covers 595 AOPs, 1,595 key events, 2,360 key event relationships, 754 stressors and 430 chemicals. AOPs, key events, key event relationships, biological events, stressors and chemicals receive identifiers.org URIs and are linked out to ChEBI, GO, PATO, UBERON, CL, NCBITaxon and HGNC. Gene names appearing in key events are matched to HGNC approved symbols and resolved to Ensembl, NCBI Gene, UniProt and Protein Ontology identifiers through BridgeDb.
The generated RDF dataset files are released under CC BY-SA 4.0. The conversion code in the AOPWikiRDF repository is separately licensed under the MIT License.
Created: August 17, 2026 | Last modified: August 17, 2026