BioPlanet

Overview

The NCATS BioPlanet is a comprehensive, publicly accessible informatics resource that catalogues all pathways, their healthy and disease state annotations, and targets within and relationships among them. The BioPlanet integrates pathway annotations from publicly available, manually curated sources that have been subjected to thorough redundancy and consistency cross-evaluation via extensive manual curation.

The resource hosts information only from public sources that have been further manually curated to ensure the quality of the data. Along with the pathway warehouse, the NCATS BioPlanet software platform allows easy browsing and visualization of the universe of pathways, and exploration of associations among them.

Information Resource ID

This resource has the Information Resource identifier: infores:bioplanet

Key Features

• Comprehensive Pathway Catalog: Incorporates 1,658 distinct human pathways encompassing 9,818 human genes (as of v1.0).
• Integrated Data: Combines data from KEGG, Reactome, WikiPathways, BioCarta, NCI-Nature PID, and Science Signaling.
• Manual Curation: Extensive manual curation to remove redundancy and ensure data quality.
• Assay Availability: Annotates pathways with availability of bioassays from Tox21, NCATS, PubChem, and commercial sources.
• Visualization: Provides interactive pathway diagrams and a 3D globe view of pathway relationships.

Publications

• Huang R, Grishagin I, Wang Y, Zhao T, Greene J, Obenauer JC, Ngan D, Nguyen D-T, Guha R, Jadhav A, Southall N, Simeonov A, Austin CP. The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics. Front Pharmacol. 2019;10:445. doi: 10.3389/fphar.2019.00445.