brenda

is a Data Source.

BRENDA (BRaunschweig ENzyme DAtabase) is the main collection of enzyme functional data available to the scientific community. It provides comprehensive information on enzyme nomenclature, reaction mechanisms, specificity, functional parameters, and enzyme-related disease information. BRENDA integrates biochemical and molecular information from primary literature, patents, and data collections to support enzyme research and applications in biotechnology, medicine, and metabolic engineering. The database is curated at the Leibniz Institute DSMZ and is part of ELIXIR Core Data Resources and the German Network for Bioinformatics Infrastructure (de.NBI).

Compare

Repository

Unknown

External IDs

RRID: RRID:SCR_002997

Product Summary

Publications

BRENDA in 2026: a Global Core Biodata Resource for functional enzyme and metabolic data within the DSMZ Digital Diversity

BRENDA, the ELIXIR core data resource in 2021: new developments and updates

Products

From this Resource

ID	Name	URL	Category	Format	Description
brenda.web	BRENDA Web Portal	www.brenda-enzymes.org	Graphical Interface	http	Web-based search and browsing interfa...
brenda.soap	BRENDA SOAP API	soap.php	Programming Interface	http	SOAP web service API providing progra...
brenda.sparql	BRENDA SPARQL Endpoint	brenda	Programming Interface	http	SPARQL endpoint for querying BRENDA k...
brenda.textfile	BRENDA Textfile Download	download.php	Product	mixed	Downloadable text files containing co...
brenda.json	BRENDA JSON Download	download.php	Product	json	Downloadable JSON files containing co...
brenda.docs	BRENDA Help and Tutorials	help.php	Documentation	http	BRENDA help and tutorial resources co...

From other Resources

ID	Name	URL	Category	Format	Relation	Description
ibkh.graph	iBKH Knowledge Graph	❔	Graph	mixed	had primary source	The integrative Biomedical Knowledge ...
biobtree.api	BioBTree REST API	api	Programming Interface	http	had primary source	REST API for searching identifiers an...
biobtree.graph.human-subgraph	BioBTree Knowledge Graph - Human Subgraph (KGX)	20816742	Graph	kgx	had primary source	Human-scoped, Neo4j-ready subgraph of...
europepmc.textmined-terms	Europe PMC Text-Mined Database Accession Links	TextMinedTerms	Mapping	csv	had primary source	CSV files, one per database, linking ...
rdf-portal.sparql.primary	RDF Portal Primary SPARQL Endpoint	sparql	Programming Interface	http	was derived from	SPARQL endpoint for the primary RDF P...

Relevant Taxa

Cellular organisms (NCBITaxon:131567)

Details

BRENDA

BRENDA (BRaunschweig ENzyme DAtabase) is the most comprehensive enzyme information system worldwide. It serves as a Global Core Biodata Resource providing detailed functional data on enzymes including kinetic parameters, molecular properties, substrates, products, inhibitors, cofactors, and disease relationships.

Key Features

Comprehensive Coverage: Over 7,500 EC-classified enzymes with data from more than 150,000 literature references
Functional Parameters: Extensive kinetic data including KM, Kcat, Ki, IC50 values, pH and temperature optima
Structural Information: Links to 3D structures, protein sequences, and enzyme-ligand interactions
Organism Information: Enzyme data across all domains of life with taxonomic classification
Disease Associations: Links between enzymes and diseases with confidence classifications
Metabolic Context: Integration with metabolic pathways and reaction networks

Data Access

BRENDA provides multiple access methods:

Web interface with advanced search capabilities
SOAP API for programmatic access
SPARQL endpoint for semantic queries
Bulk downloads in text and JSON formats
Integration with other biological databases

The database is curated at the Leibniz Institute DSMZ in Germany and is part of the ELIXIR Core Data Resources and de.NBI infrastructure.