brenda

is a Data Source.

BRENDA (BRaunschweig ENzyme DAtabase) is the main collection of enzyme functional data available to the scientific community. It provides comprehensive information on enzyme nomenclature, reaction mechanisms, specificity, functional parameters, and enzyme-related disease information. BRENDA integrates biochemical and molecular information from primary literature, patents, and data collections to support enzyme research and applications in biotechnology, medicine, and metabolic engineering. The database is curated at the Leibniz Institute DSMZ and is part of ELIXIR Core Data Resources and the German Network for Bioinformatics Infrastructure (de.NBI).

Domains

chemistry and biochemistry, pathways, biomedical

License

CC BY 4.0

Homepage

brenda

Repository

Unknown

Infores ID

Unknown

FAIRsharing ID

Unknown

Product Summary

Products

From this Resource
ID Name URL Category Format Description
brenda.web BRENDA Web Portal www.brenda-enzymes.org GraphicalInterface http Web-based search and browsing interfa...
brenda.soap BRENDA SOAP API soap.php ProgrammingInterface http SOAP web service API providing progra...
brenda.sparql BRENDA SPARQL Endpoint brenda ProgrammingInterface http SPARQL endpoint for querying BRENDA k...
brenda.textfile BRENDA Textfile Download download.php Product mixed Downloadable text files containing co...
brenda.json BRENDA JSON Download download.php Product json Downloadable JSON files containing co...
From other Resources
ID Name URL Category Format Description
ibkh.graph iBKH Knowledge Graph ❔ GraphProduct ❔ The integrative Biomedical Knowledge ...

Details

BRENDA

BRENDA (BRaunschweig ENzyme DAtabase) is the most comprehensive enzyme information system worldwide. It serves as a Global Core Biodata Resource providing detailed functional data on enzymes including kinetic parameters, molecular properties, substrates, products, inhibitors, cofactors, and disease relationships.

Key Features

  • Comprehensive Coverage: Over 7,500 EC-classified enzymes with data from more than 150,000 literature references
  • Functional Parameters: Extensive kinetic data including KM, Kcat, Ki, IC50 values, pH and temperature optima
  • Structural Information: Links to 3D structures, protein sequences, and enzyme-ligand interactions
  • Organism Information: Enzyme data across all domains of life with taxonomic classification
  • Disease Associations: Links between enzymes and diseases with confidence classifications
  • Metabolic Context: Integration with metabolic pathways and reaction networks

Data Access

BRENDA provides multiple access methods:

  • Web interface with advanced search capabilities
  • SOAP API for programmatic access
  • SPARQL endpoint for semantic queries
  • Bulk downloads in text and JSON formats
  • Integration with other biological databases

The database is curated at the Leibniz Institute DSMZ in Germany and is part of the ELIXIR Core Data Resources and de.NBI infrastructure.

Is this information incorrect or incomplete? Request an update.

Created: November 19, 2025 | Last modified: November 19, 2025