is a Data Source.
CellMiner is a web-based suite from the Genomics and Pharmacology Facility of the NCI Developmental Therapeutics Branch for exploring molecular profiles and drug activity data of the NCI-60 cancer cell line panel. It integrates DNA (copy number, mutation, methylation), RNA (microarray, RNA-seq, microRNA), protein and compound activity data (DTP NCI-60 screen, HTS384 screen and NCI-ALMANAC combination scores), and provides processed and raw data downloads. Its companion application CellMinerCDB extends cross-database analysis to other cancer cell line pharmacogenomic datasets, including CCLE, GDSC, CTRP, PRISM and Project Achilles.
biomedical, cancer, pharmacology, pharmacogenomics, genomics
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| cellminer.portal | CellMiner Portal | cellminer | Graphical Interface | http | CellMiner web portal for querying NCI... |
| cellminer.downloads | CellMiner Data Downloads | loadDownload.do | Product | http | CellMiner download page listing proce... |
| cellminer.drug-zscore | CellMiner DTP NCI-60 Drug Activity Z-Scores | DTP_NCI60_ZSCORE.zip (8.1 MB) | Product | xlsx | Processed DTP NCI-60 compound activit... |
| cellminer.drug-raw | CellMiner DTP NCI-60 Raw Drug Activity | DTP_NCI60_RAW.zip (20.5 MB) | Product | xlsx | Raw DTP NCI-60 compound activity data... |
| cellminer.cellminercdb | CellMinerCDB | cellminercdb | Graphical Interface | http | CellMinerCDB web application for inte... |
| cellminer.rcellminer | rcellminer R Package | rcellminer.html | Programming Interface | r | rcellminer Bioconductor package provi... |
| cellminer.rcellminerdata | rcellminerData R Package | rcellminerData.html | Product | r | rcellminerData Bioconductor experimen... |
| cellminer.dataset-metadata | CellMiner Dataset Metadata | datasets.do | Documentation | http | CellMiner dataset metadata page descr... |
| cellminer.release-notes | CellMiner Release Notes | releaseNotes.do | Documentation | http | CellMiner release notes describing da... |
CellMiner is a suite of web tools from the Genomics and Pharmacology Facility (GPF) of the Developmental Therapeutics Branch at the U.S. National Cancer Institute. It integrates the molecular and pharmacological data collected for the NCI-60 panel of human cancer cell lines, the cell lines used in the NCI Developmental Therapeutics Program (DTP) anti-cancer drug screen.
CellMiner covers DNA data (copy number from several aCGH and SNP platforms, exome sequencing mutations, DNA methylation), RNA data (Affymetrix, Agilent and RNA-seq transcript expression, microRNA arrays, transporter arrays), protein data (antibody arrays, SWATH mass spectrometry, cell surface markers, histone marks) and compound activity data (the DTP NCI-60 screen, the HTS384 screen and NCI-ALMANAC drug combination scores). Processed and raw datasets can be downloaded from the download page as ZIP archives of Excel workbooks with documentation.
CellMinerCDB is a companion Shiny application for cross-database analysis. It lets users compare molecular and drug response data from NCI-60 with other cancer cell line sets, including CCLE (Broad-MIT), GDSC (MGH-Sanger), CTRP, PRISM, Project Achilles, NCI-DTP small cell lung cancer lines, MD Anderson and NCATS datasets. The GPF also hosts specialized CellMinerCDB instances for small cell lung cancer, sarcoma and adrenocortical carcinoma.
The rcellminer and rcellminerData Bioconductor packages provide CellMiner NCI-60 data and analysis functions in R.
Created: October 04, 2026 | Last modified: October 05, 2026