is a Data Source.
DATE (Drugs to target pAthways by the Tissue Expression) is a dataset from the Tatonetti lab connecting 1,034 drugs to 954 Reactome pathways in 259 human tissues and cell lines. It combines DrugBank drug-target pairs with tissue expression from GTEx, the GNF U133A gene atlas, the NCI-60 cell lines and the Human Proteome Map. It has not been updated since 2018.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| date.archive | DATE Archive ZIP | DATE.zip (6.9 MB) | Product | tsv | ZIP with two TSV files: Drug_target_r... |
DATE (Drugs to target pAthways by the Tissue Expression) was a computational resource developed to integrate drug-target information with biological pathway data and tissue-specific gene expression patterns. The goal was to predict tissue-specific drug effects and identify therapeutic opportunities based on pathway perturbations in specific tissue contexts.
The DATE resource appears to be inactive. The homepage URL points to an archived ZIP file on Amazon S3, suggesting the resource is no longer actively maintained or updated. No recent publications or updates are available.
DATE represented an important approach to integrating multiple data types (drugs, targets, pathways, expression) for predicting tissue-specific pharmacological effects, contributing to the field of computational systems pharmacology.
Created: October 30, 2025 | Last modified: October 04, 2026