is an Aggregator.
dbNSFP is a database of functional predictions and annotations for all potential non-synonymous single-nucleotide variants (nsSNVs) and splice-site SNVs (ssSNVs) in the human genome. It compiles deleteriousness prediction scores from 37 algorithms (including SIFT, PolyPhen-2, CADD, REVEL, AlphaMissense and its own ensemble scores MetaSVM, MetaLR and MetaRNN), evolutionary conservation scores, allele frequencies from population sequencing projects, ClinVar classifications and extensive gene-level annotations. Release 5.4 (August 2026) is based on GENCODE release 50 / Ensembl 116 and covers 86,701,498 nsSNVs and 2,582,202 ssSNVs. It is distributed in an academic branch (free for non-commercial use under CC BY-NC-ND 4.0, with registration) and a commercial branch (paid license) that omits components whose authors restrict commercial use.
No external IDs available
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| dbnsfp.browser | dbNSFP Public Variant Browser | query.dbnsfp.org | Graphical Interface | http | dbNSFP Public Variant Browser, a free... |
| dbnsfp.academic | dbNSFP Academic Branch | download | Product | tsv | Academic branch of dbNSFP (v5.4a at t... |
| dbnsfp.commercial | dbNSFP Commercial Branch | license | Product | tsv | Commercial branch of dbNSFP (v5.4c at... |
| dbnsfp.academic-portal | dbNSFP Academic Portal | query.genos.us | Graphical Interface | http | Academic Portal for searching the ful... |
| dbnsfp.readme | dbNSFP v5.4a README | dbNSFP5.4a.readme.txt | Documentation | txt | README for dbNSFP v5.4a, listing the ... |
| dbnsfp.variant-columns | dbNSFP v5.4a Variant Columns | dbNSFP5.4a_variant.columns.txt | Documentation | txt | Column descriptions for the dbNSFP v5... |
| dbnsfp.legacy | dbNSFP Legacy Website | dbNSFP | Documentation | http | Legacy dbNSFP website documenting ver... |
| dbnsfp.dbscsnv ⚠ | dbscSNV v1.1 | ffwlywsat3q5ijypvunno3rg6steqfs8 | Product | tsv | dbscSNV v1.1, a companion database of... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| myvariant.api | MyVariant.info API | query | Programming Interface | http | had primary source | MyVariant.info REST API (v1) for vari... |
dbNSFP is a one-stop database of functional predictions and annotations for every possible non-synonymous and splice-site single-nucleotide variant in human protein-coding genes, including mitochondrial DNA. Xiaoming Liu created it in 2011, and it is now developed by Genos Bioinformatics LLC. New releases appear three to five times a year.
The academic branch (“a”) includes every upstream resource that is free for academic use. It is distributed under CC BY-NC-ND 4.0 to registered users with an institutional email. The commercial branch (“c”) is sold under a paid license and leaves out components whose authors restrict commercial use (CADD, VEST, M-CAP, MutScore, PolyPhen-2, PrimateAI and RGC Million Exome in v5.4c). Users of either branch must also comply with the licenses of the individual components, as listed in the README.
A free Public Variant Browser supports small lookups. dbNSFP data are also served through third-party tools such as Ensembl VEP, ANNOVAR, SnpSift, OpenCRAVAT, VarSome and the UCSC Genome Browser, often from older versions.
Versions 1.x to 4.x are documented on the legacy site, but its Amazon S3 download links for v4.9 returned HTTP 404 when checked on 2026-10-04. The companion splice-site database dbscSNV (v1.1, 2015) can be attached to dbNSFP and queried along with it.
Created: October 04, 2026 | Last modified: October 04, 2026