is a Data Source.
The Cancer Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout and small molecule screen of cancer cell lines. The goal of DepMap is to systematically identify cancer dependencies and the biomarkers that predict them. DepMap provides open access to key cancer dependencies, analytical tools, and visualization resources for the research community.
infores:depmap
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| depmap.portal | DepMap Portal | portal | GraphicalInterface | http | Web portal for exploring cancer depen... |
| depmap.api | DepMap API | api | ProgrammingInterface | json | DepMap portal API for programmatic ac... |
| depmap.data_explorer | DepMap Data Explorer | interactive | GraphicalInterface | http | Interactive tool for exploring relati... |
| depmap.cell_line_selector | DepMap Cell Line Selector | cell_line_selector | GraphicalInterface | http | Tool for exploring and selecting canc... |
| depmap.context_explorer | DepMap Context Explorer | context | GraphicalInterface | http | Context Explorer tool for exploring e... |
| depmap.target_discovery | DepMap Target Discovery | tda | GraphicalInterface | http | Target Discovery App for identifying ... |
| depmap.downloads ⚠ | DepMap Data Downloads | ?tab=currentRelease | Product | mixed | Complete collection of DepMap dataset... |
| depmap.crispr_gene_effects | DepMap CRISPR Gene Effects (Chronos) | data_page | Product | csv | CRISPR-Cas9 knockout screening data p... |
| depmap.drug_sensitivity | DepMap Drug Sensitivity Data | data_page | Product | csv | Drug screening data from various plat... |
| depmap.expression_data | DepMap Expression Data | data_page | Product | csv | Gene expression data (RNA-seq) for De... |
| depmap.copy_number | DepMap Copy Number Data | data_page | Product | csv | Copy number variation data for DepMap... |
| depmap.mutations | DepMap Mutation Data | data_page | Product | csv | Mutation data for DepMap cell lines |
| depmap.proteomics | DepMap Proteomics Data | data_page | Product | csv | Proteomics data for DepMap cell lines |
| depmap.metabolomics | DepMap Metabolomics Data | data_page | Product | csv | Metabolomics data for DepMap cell lines |
| depmap.cell_line_info | DepMap Cell Line Information | data_page | Product | csv | Comprehensive metadata and annotation... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| bioteque.embeddings | Bioteque Embeddings | embeddings | Product | ❔ | had primary source | Network embeddings of the Bioteque gr... |
| obo-db-ingest.depmap.tsv | depmap Nodes TSV | depmap.tsv (18.3 KB) | Product | tsv | had primary source | depmap Nodes TSV |
| enrichr-kg.graph | Enrichr-KG Neo4j Database | ❔ | GraphProduct | neo4j | had primary source | Neo4j graph database integrating Enri... |
| achilles.downloads ⚠ | Project Achilles Data Releases | all | Product | http | had primary source | DepMap all-data downloads page where ... |
| prism.datasets ⚠ | PRISM Drug Sensitivity Dataset Downloads | ?tab=allData | Product | csv | was informed by | DepMap downloads page for PRISM Repur... |
| prism.primary_screen_lfc ⚠ | PRISM Repurposing Primary Screen Log-Fold Change | 20237709 | Product | csv | was informed by | Replicate-collapsed log-fold-change m... |
| prism.secondary_screen_dose_response ⚠ | PRISM Repurposing Secondary Screen Dose Response | 20237739 | Product | csv | was informed by | Dose-response curve parameter matrix ... |
| harmonizome.downloads | Harmonizome Downloads | download | Product | mixed | was derived from | Harmonizome 3.0 processed dataset dow... |
| harmonizome.kg-neo4j | Harmonizome Knowledge Graph Neo4j Database | harmonizome-kg.maayanlab.cloud | GraphProduct | neo4j | was derived from | Neo4j knowledge graph serialization o... |
The Cancer Dependency Map (DepMap) is a comprehensive effort to systematically identify cancer dependencies and the biomarkers that predict them. As a collaborative initiative led by the Broad Institute, DepMap aims to accelerate the development of precision treatments for cancer by providing open access to key cancer dependency data, analytical tools, and visualization resources.
DepMap uses genome-wide pooled CRISPR-Cas9 knockout screens and small molecule screens across thousands of genomically characterized cancer cell lines to identify dependencies that are specific to tumor subsets. These dependencies represent potential therapeutic targets, as they are genes or pathways that cancer cells rely on for survival but that normal cells can tolerate losing.
Interactive visualization tool allowing users to explore relationships between different data types, compare biomarkers, and identify patterns across cell lines.
Specialized tool for identifying and selecting cell lines based on specific criteria such as lineage, mutations, expression levels, or dependency profiles.
Advanced analytics platform for identifying the most selective and predictable gene dependencies, helping prioritize potential therapeutic targets.
Tool for exploring genetic dependencies and compound sensitivities within specific cancer contexts, lineages, and molecular subtypes.
DepMap data enables researchers to:
All DepMap data is freely available through:
When using DepMap data, please cite the foundational publications and acknowledge the specific data release version used in your research.
Created: October 09, 2025 | Last modified: June 01, 2026