is a Data Source.
The Database of Interacting Proteins (DIP) is a curated biological database that catalogs experimentally determined interactions between proteins, developed and maintained by the research group of David Eisenberg at the University of California Los Angeles (UCLA). Established in 2002, DIP combines information from diverse sources to create a unified, consistent set of protein-protein interactions with both manual expert curation and automated computational approaches that leverage knowledge extracted from the most reliable core subset of the data. DIP serves as a member of the International Molecular Exchange (IMEx) Consortium, an international collaboration of major public providers of protein interaction data including IntAct, MINT, BioGRID, and others that work together to avoid duplication of curation efforts by collecting data from non-overlapping sources and sharing curated interaction data. The database enables searches through its web interface based on multiple criteria including interactions described in specific journal articles, interactions supported by particular types of experimental evidence, and protein identifiers or sequences. DIP data have been curated using both manual approaches by expert biologists and automated computational methods that utilize machine learning and network analysis of the high-confidence core interaction data. The IMEx consortium developed the HUPO Proteomics Standards Initiative Molecular Interaction (HUPO-PSI-MI) XML format, which has become widely implemented for standardizing molecular interaction data representation. All information within DIP is freely available under a Creative Commons Attribution-NoDerivatives 3.0 license. DIP provides downloads of complete datasets and specialized subsets, supporting integration with other protein interaction databases and serving as a foundational resource for systems biology, network analysis, and protein function prediction studies.
biological systems
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infores:dip
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| dip.search | DIP Search Interface | Search.cgi | GraphicalInterface | ❔ | Web-based search interface for explor... |
| dip.downloads ⚠ | DIP Data Downloads | Download.cgi | Product | psi_mi_mitab | Complete DIP dataset and specialized ... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| irefindex.database | iRefIndex Database | ❔ | Product | psi_mi_mitab | had primary source | Historical consolidated protein inter... |
| string.protein.links | STRING Protein Links | protein.links.v12.0.txt.gz (128.7 GB) | GraphProduct | txt | had primary source | protein network data (full network, s... |
| string.protein.links.detailed | STRING Protein Links Detailed | protein.links.detailed.v12.0.txt.gz (189.6 GB) | GraphProduct | txt | had primary source | protein network data (full network, i... |
| string.protein.links.full | STRING Protein Links Full | protein.links.full.v12.0.txt.gz (199.6 GB) | GraphProduct | txt | had primary source | protein network data (full network, i... |
| string.protein.physical.links | STRING Protein Physical Links | protein.physical.links.v12.0.txt.gz (11.1 GB) | GraphProduct | txt | had primary source | protein network data (physical subnet... |
| string.protein.physical.links.detailed | STRING Protein Physical Links Detailed | protein.physical.links.detailed.v12.0.txt.gz (13.8 GB) | GraphProduct | txt | had primary source | protein network data (physical subnet... |
| string.protein.physical.links.full | STRING Protein Physical Links Full | protein.physical.links.full.v12.0.txt.gz (14.5 GB) | GraphProduct | txt | had primary source | protein network data (physical subnet... |
| string.cog.links | STRING COG Links | COG.links.v12.0.txt.gz (176.8 MB) | GraphProduct | txt | had primary source | association scores between orthologou... |
| string.cog.links.detailed | STRING COG Links Detailed | COG.links.detailed.v12.0.txt.gz (238.7 MB) | GraphProduct | txt | had primary source | association scores (incl. subscores p... |
| string.database | STRING Database Network Schema | network_schema.v12.0.sql.gz (262.2 GB) | GraphProduct | ❔ | had primary source | full database, part II: the networks ... |
The Database of Interacting Proteins (DIP) is a curated resource for experimentally validated protein-protein interactions, maintained by UCLA as part of the IMEx consortium.
Created: November 10, 2025 | Last modified: April 16, 2026