Domains

proteomics, biological systems

License

Creative Commons Attribution 4.0 International (CC BY 4.0)

Homepage

disprot

Repository

Unknown

Infores ID

infores:disprot

FAIRsharing ID

Unknown

Product Summary

Contacts

DisProt Team

Email: info@disprot.org

Damiano Piovesan

Publications

Preferred

Products

From this Resource

ID	Name	URL	Category	Format	Description
disprot.browser	DisProt Browser	browse	GraphicalInterface	http	Web interface for browsing and search...
disprot.downloads	DisProt Downloads	download	Product	json	Bulk download of DisProt data in mult...
disprot.api	DisProt API	api	ProgrammingInterface	http	RESTful API for programmatic access t...
disprot.deposition	DisProt Deposition System	deposition.disprot.org	GraphicalInterface	❔	Deposition system for submitting expe...
disprot.idpo	IDP Ontology (IDPO)	IDPO_v0.3.0.owl (49.8 KB)	OntologyProduct	owl	IDP Ontology (IDPO) for representing ...

Details

DisProt

Overview

DisProt is the major manually curated repository of intrinsically disordered proteins (IDPs), covering both structural and functional aspects. Expert curators collect experimentally confirmed biological data on protein disorder, making it a valuable resource for the scientific community. DisProt is part of the ELIXIR infrastructure and serves the IDP Community.

Data Content

DisProt provides comprehensive annotations for:

Intrinsically Disordered Regions (IDRs): Experimentally validated regions of structural disorder in proteins
Functional Annotations: Biological functions associated with disordered regions
Experimental Evidence: Curated experimental data supporting disorder and function annotations
Cross-references: Integration with UniProt, InterPro, Gene Ontology, and Evidence Ontology

Current release (9.8, 2025_06) contains 3,201 entries covering multiple organisms:

Human: 952 entries
Mouse: 198 entries
Rat: 89 entries
Yeast: 209 entries
E. coli: 8 entries
Arabidopsis: 114 entries
Fly: 64 entries

Key Features

Manual curation by expert biocurators following standardized guidelines
Daily updates and maintenance
Experimentally validated annotations from published scientific literature
Thematic datasets on specific topics (e.g., age-related disorders)
Integration with major biological databases
Training materials and courses for biocuration

Access Methods

Web Browser: Interactive search and browse interface
Bulk Downloads: Complete database exports in JSON, TSV, FASTA, and GAF formats
REST API: Programmatic data access for computational workflows
Deposition System: Portal for submitting new experimental data

Use Cases

Training and validation of disorder prediction methods (CAID - Critical Assessment of Protein Intrinsic Disorder Prediction)
Studying structure-function relationships in disordered proteins
Analyzing disease-associated protein disorder
Developing computational tools for IDP analysis
Meta-analyses of protein disorder across organisms

IDP Ontology

DisProt maintains the IDP Ontology (IDPO) v0.3.0, which represents functional aspects of intrinsically disordered proteins. Available in JSON, OWL, and OBO formats with mappings to Gene Ontology and Evidence & Conclusion Ontology terms.

Management

DisProt is maintained by the BioComputing UP group at the University of Padua, Italy, led by:

Prof. Silvio C.E. Tosatto (Team Leader)
Prof. Damiano Piovesan (Team Leader & Software Developer)
Dr. Maria Cristina Aspromonte (DisProt Manager)

The project operates with an international Scientific Advisory Board and is funded by the European Union’s Horizon 2020 programme (grant agreement No. 778247).

Funding

European Union’s Horizon 2020 research and innovation programme under grant agreement No. 778247.