dorothea

is a Knowledge Graph.

DoRothEA is a curated resource of transcription factor (TF) – target gene (regulon) interactions with confidence scoring, enabling inference of TF activity from gene expression data. It integrates literature-curated interactions and various experimental evidence (e.g. ChIP-seq, TF binding motifs, perturbation data) to build context-agnostic and confidence-stratified regulons for multiple species. Frequently used with PROGENy to estimate pathway and TF activities.