is a Data Source.
DrugShot is a web server from the Ma'ayan Laboratory that takes any biomedical search term and returns drugs and small molecules ranked by how often they are co-mentioned with that term in PubMed, using the automatically generated DrugRIF and AutoRIF drug-publication associations. It also predicts additional compounds from drug-drug similarity matrices built from literature co-mentions and from L1000 drug-induced gene expression signatures.
No external IDs available
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| drugshot.portal | DrugShot Web Application | drugshot | Graphical Interface | http | Web server that returns drugs and sma... |
| drugshot.api | DrugShot API | api.html | Programming Interface | json | REST API with POST endpoints to searc... |
| drugshot.downloads | DrugShot Downloads | download.html | Product | http | Download page for the DrugRIF and Aut... |
| drugshot.drugrif | DrugRIF Drug-Publication Associations | DrugRIF.tsv.gz (8.6 MB) | Product | tsv | About 2 million drug to PubMed articl... |
| drugshot.autorif | AutoRIF Drug-Publication Associations | AutoRIF.tsv.gz (31.8 MB) | Product | tsv | About 8 million drug to PubMed articl... |
| drugshot.l1000-similarity | L1000 Drug-Drug Similarity Matrix | L1000_coexpression.h5 (1.4 GB) | Product | hdf5 | Drug-drug similarity matrix from cosi... |
| drugshot.autorif-cooccurrence | AutoRIF Drug Co-mention Matrix | autorif_cooccur.h5 (154.6 MB) | Product | hdf5 | Drug-drug co-mention matrix computed ... |
| drugshot.drugrif-cooccurrence | DrugRIF Drug Co-mention Matrix | drugrif_cooccur.h5 (146.6 MB) | Product | hdf5 | Drug-drug co-mention matrix computed ... |
| drugshot.source | DrugShot Source Code | drugshot | Process | python | Source code for the DrugShot web serv... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| reprotox-kg.graph.core | ReproTox-KG Core Graph | reprotox_serialization.valid.json (1.6 MB) | Graph | json | had primary source | Core ReproTox-KG graph linking birth ... |
| reprotox-kg.graph.drugshot-hpo | ReproTox-KG DrugShot HPO-Drug Graph | Drugshot_HPO_to_Drug.valid.json (8.5 MB) | Graph | json | had primary source | Birth defect phenotype to drug associ... |
DrugShot, from the Ma’ayan Laboratory at the Icahn School of Medicine at Mount Sinai, ranks drugs and small molecules by their relevance to any biomedical search term. It queries PubMed through NCBI E-utilities and cross-references the matching articles with automatically generated drug-publication associations.
DrugRIF holds about 2 million drug-publication associations, built by querying PubMed with the InChIKeys of Drugmonizome and SEP-L1000 compounds through PubChem. AutoRIF holds about 8 million, built by querying PubMed with drug names matched to MeSH. DrugShot predicts additional compounds from drug-drug similarity matrices based on DrugRIF and AutoRIF co-mentions and on cosine similarity of L1000 drug-induced gene expression signatures from SEP-L1000. All of these files are downloadable. (On the download page, the AutoRIF link points to the DrugRIF file; the AutoRIF file listed here is the one the application loads.)
DrugShot is available as a web application and a REST API. The source code is on GitHub under the Apache License 2.0; commercial users are asked to contact Mount Sinai Innovation Partners. DrugShot feeds the DrugShot HPO-drug graph in ReproTox-KG.
Created: October 10, 2026 | Last modified: October 10, 2026