erccrbp

is a Data Source.

ERCC RNA Binding Protein dataset (ERCCRBP) is a collection of data focused on RNA binding proteins involved in extracellular RNA functions as part of the NIH Common Fund's Extracellular RNA Communication Consortium (ERCC) program. This dataset provides insights into the protein-RNA interactions important for exRNA stability, transport, and signaling.

Domains

biomedical, genomics, chemistry and biochemistry

License

CC BY 4.0

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erccrbp

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Details

ERCC RNA Binding Protein Dataset

The ERCC RNA Binding Protein Dataset (ERCCRBP) is part of the research conducted by the NIH Common Fund’s Extracellular RNA Communication Consortium (ERCC), which explores the biology and function of extracellular RNA (exRNA).

Overview

RNA binding proteins (RBPs) play critical roles in the biology of extracellular RNA by influencing RNA stability, transport, cellular uptake, and signaling functions. The ERCCRBP dataset focuses on these protein-RNA interactions that are fundamental to understanding exRNA communication between cells and potential applications in biomarker discovery and therapeutics.

Research Context

This dataset is part of the broader ERCC initiative which aims to:

  1. Investigate the roles of RNA binding proteins in exRNA biogenesis, secretion, and transport
  2. Characterize RBP-exRNA complexes found in various biofluids
  3. Understand how RBPs protect exRNAs from degradation in the extracellular environment
  4. Explore the potential of exRNA-RBP interactions as diagnostic biomarkers or therapeutic targets

Research Findings

Studies of RNA binding proteins associated with extracellular RNA have revealed:

  • Specific RBPs are involved in packaging RNAs into extracellular vesicles
  • Different subpopulations of exRNAs associate with distinct carrier types, including RBPs
  • RBPs can protect exRNAs from degradation by RNases present in biofluids
  • The exRNA-RBP complex profile differs across disease states and may serve as sensitive biomarkers

Data Access

The ERCC RNA Binding Protein dataset is referenced by other resources in the knowledge graph registry, but access to the primary data may be restricted. Interested researchers should contact the ERCC directly via the exRNA portal for information on data availability and access procedures.

For more information about exRNA research and related datasets, you can visit:

The exRNA Atlas contains small RNA sequencing and qPCR-derived exRNA profiles from human and mouse biofluids, processed using standardized pipelines and quality metrics. The ERCCRBP dataset complements these resources by focusing on the protein components of exRNA complexes.

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Created: June 04, 2025 | Last modified: October 15, 2025