is a Data Source.
FIRE (Frequently Interacting REgions) are genomic regions that participate in an unusually high number of local chromatin interactions, identified from high-throughput chromosome conformation capture (Hi-C) data. They were defined by Schmitt et al. (Cell Reports, 2016), who built a compendium of chromatin contact maps across 14 human primary tissues and cell types and showed that FIREs mark spatially active, cell-type-specific regions of the genome enriched for super-enhancers and disease-associated variants. FIRE serves as an upstream chromatin-architecture data layer in GenomicKB, contributing three-dimensional genome-organization annotations to that knowledge graph.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| fire.publication | FIRE compendium of chromatin contact maps | PMC5135022 | DataSource | ❔ | Schmitt et al. (2016) compendium of c... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| genomickb.graph | GenomicKB Graph Dump | genomickb-a-knowledgebase-for-the-human-genome | GraphProduct | http | had primary source | GenomicKB 1.0 Neo4j Database Dump (Re... |
FIRE (Frequently Interacting REgions) identifies genomic regions that frequently take part in local chromatin interactions, called from Hi-C data. Introduced by Schmitt et al. (Cell Reports, 2016), FIREs highlight spatially active, often cell-type-specific portions of the human genome and are used as an upstream chromatin-architecture data layer in GenomicKB.
The original FIRE-calling code was published as the fishHiC repository
(github.com/yunliUNC/fishHiC), but that repository no longer resolves, so this
record points to the peer-reviewed publication and its archived data as the
canonical source. Because FIRE represents a static, published analysis with no
maintained software or data portal, its activity status is recorded as inactive.
Created: June 18, 2026 | Last modified: June 18, 2026