gdsc

is a Data Source.

The Genomics of Drug Sensitivity in Cancer (GDSC) is a database and resource that characterizes cancer cell lines and their responses to anti-cancer drugs. It contains drug screening data for over 1000 cancer cell lines with hundreds of compounds, as well as genomic feature data such as mutations, copy number variations, methylation, and gene expression. The aim is to identify molecular features of cancers that predict response to anti-cancer drugs.

Domains

biomedical, health, drug discovery, genomics, pharmacology

Infores ID

infores:gdsc

FAIRsharing ID

Unknown

Product Summary

Contacts

Genomics of Drug Sensitivity in Cancer Project

URL: https://www.cancerrxgene.org/

Wellcome Sanger Institute

URL: https://www.sanger.ac.uk/

Massachusetts General Hospital Cancer Center

URL: http://www.massgeneral.org/cancer/

Publications

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells Preferred

A landscape of pharmacogenomic interactions in cancer

Systematic identification of genomic markers of drug sensitivity in cancer cells

Products

From this Resource

ID	Name	URL	Category	Format	Description
gdsc.site	GDSC Web Interface	www.cancerrxgene.org	GraphicalInterface	http	Web interface for searching and brows...
gdsc.drug_data	GDSC Drug Sensitivity Data	drug_data	Product	csv	Drug sensitivity data including IC50 ...
gdsc.anova	GDSC ANOVA Results	anova	Product	csv	ANOVA analysis results of association...
gdsc.genetic_features	GDSC Genetic Features	genetic_features	Product	csv	Genetic feature data including mutati...
gdsc.ftp ⚠	GDSC FTP Data Repository	releases	Product	csv	FTP repository with all GDSC data rel...

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spoke.graph	SPOKE Graph	❔	GraphProduct	❔	The SPOKE knowledge graph containing ...
bioteque.embeddings	Bioteque Embeddings	embeddings	Product	❔	Network embeddings of the Bioteque gr...

Relevant Taxa

Human (NCBITaxon:9606)

Details

Overview

The Genomics of Drug Sensitivity in Cancer (GDSC) is a major collaboration between the Cancer Genome Project at the Wellcome Sanger Institute (UK) and the Center for Molecular Therapeutics at Massachusetts General Hospital Cancer Center (USA). The project aims to discover therapeutic biomarkers that can help identify patients most likely to respond to different anti-cancer drugs.

Features

Drug sensitivity data for over 1000 human cancer cell lines
Screening results for hundreds of anti-cancer compounds
Comprehensive genomic characterization of cell lines
Statistical associations between genomic features and drug sensitivity
Web interface for browsing and analyzing data
Download options for all datasets
Regular updates with new data releases

Data Content

GDSC contains several key types of data:

Drug screening data: IC50 values and dose-response curves for cancer cell lines treated with different compounds
Genomic features: Mutations, copy number variations, gene expression, and methylation data for cancer cell lines
Statistical analyses: ANOVA results showing associations between genomic features and drug responses
Annotations: Detailed information about cell lines and compounds

History

The GDSC database was established as part of the Cancer Genome Project at the Wellcome Sanger Institute. The first major publication describing the resource was released in 2012, with subsequent updates expanding the dataset and refining the analytical methods. The current version (Release 8.5, October 2023) includes data for 970 cell lines in GDSC1 and 969 cell lines in GDSC2, with a total of over 576,000 dose-response curves.