gendr

is a Data Source.

GenDR (Database of Dietary Restriction-Related Genes) is a curated database of genes associated with dietary restriction (DR) and its effects on longevity and aging. Part of the Human Ageing Genomic Resources (HAGR), GenDR compiles experimental data on genes whose expression or function is altered by dietary restriction regimens across multiple model organisms. The database includes information on gene function, expression changes, and links to aging-related phenotypes.

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Domains

genomics, biomedical, nutrition, biological systems

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Homepage

gendr

Repository

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Infores ID

infores:gendr

FAIRsharing ID

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Product Summary

Products

From this Resource
ID Name URL Category Format Description
gendr.web GenDR Web Interface diet GraphicalInterface http Web-based search and browsing interfa...
gendr.data GenDR Data Download dataset.zip (8.0 KB) Product csv Downloadable dataset of dietary restr...
gendr.expression-signatures GenDR Dietary Restriction Expression Signatures TableS2.xls (48.0 KB) Product http Excel spreadsheet of dietary-restrict...

Details

GenDR Database of Dietary Restriction-Related Genes

Overview

GenDR (Database of Dietary Restriction-Related Genes) is a curated database of genes associated with dietary restriction (DR) and its effects on longevity and aging. Part of the Human Ageing Genomic Resources (HAGR), GenDR compiles experimental data on genes whose expression or function is altered by dietary restriction regimens across multiple model organisms.

Key Features

  • Curated Gene Data: Manually curated information on DR-related genes
  • Multi-Organism Coverage: Data from multiple model organisms including yeast, worms, flies, mice, and rats
  • Expression Data: Gene expression changes under dietary restriction conditions
  • Longevity Links: Connections between DR genes and aging/longevity phenotypes
  • Functional Annotations: Gene function and pathway information

Research Applications

GenDR supports research in:

  • Aging and longevity mechanisms
  • Caloric restriction effects on gene expression
  • Nutrigenomics and metabolic regulation
  • Translational gerontology research
  • Systems biology of aging

Products

Web Interface

Search and browse dietary restriction-related genes through an interactive web interface with detailed gene information and cross-references.

Data Downloads

Download complete datasets of GenDR genes and associated metadata for computational analysis. HAGR lists GenDR Build 4 with 214 gene manipulations and 172 expression changes.

Expression Signatures

The dietary restriction gene expression signatures are available as an Excel spreadsheet linked from the HAGR downloads page.

Information Resource ID

This resource has the Information Resource identifier: infores:gendr

Publications

Domains

  • Genomics
  • Health
  • Nutrition
  • Biological Systems

Taxon Coverage

Eukaryota (NCBITaxon:2759) - includes yeast, C. elegans, Drosophila, rodents, and other model organisms

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Created: November 05, 2025 | Last modified: June 12, 2026