is a Data Source.
A reference catalogue of human genetic variation, aggregating and harmonizing exome and genome sequencing data from large-scale sequencing projects to provide population allele frequencies and gene-level constraint metrics.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| gnomad.browser | gnomAD browser | gnomad.broadinstitute.org | GraphicalInterface | http | The gnomAD browser, providing search ... |
| gnomad.downloads | gnomAD data downloads | downloads | Product | vcf | Bulk downloads of gnomAD variant data... |
| gnomad.api | gnomAD GraphQL API | api | ProgrammingInterface | graphql | A public GraphQL API for programmatic... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| sniff.federation-nodes | Sniff KGX federation export, nodes | sniff_nodes.tsv (3.6 MB) | GraphProduct | kgx | was derived from | A Biolink-conformant KGX TSV node fil... |
The Genome Aggregation Database (gnomAD) is a resource developed by an international coalition of investigators to aggregate and harmonize exome and genome sequencing data from a wide variety of large-scale sequencing projects. It is hosted by the Broad Institute.
The v4.1 dataset, aligned to GRCh38, spans 730,947 exome sequences and 76,215 whole-genome sequences from unrelated individuals of diverse ancestries. gnomAD is widely used as a population reference for variant interpretation, providing allele frequencies stratified by genetic ancestry group alongside gene-level constraint metrics.
Primary data from the gnomAD exomes and genomes are released free of restrictions under the Creative Commons Zero Public Domain Dedication, though the project requests attribution where possible.
Created: August 12, 2026 | Last modified: August 12, 2026