is a Data Source.
The IUPHAR/BPS Guide to PHARMACOLOGY is an expert-curated resource providing quantitative information on drug targets and the substances that act on them, including approved drugs and experimental therapeutics
pharmacology, health, biomedical, drug discovery, translational
infores:gtopdb
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| gtopdb.web | Guide to Pharmacology Web Interface | www.guidetopharmacology.org | GraphicalInterface | ❔ | A web-based interface for accessing a... |
| gtopdb.api.rest | Guide to Pharmacology REST API | webServices.jsp | ProgrammingInterface | ❔ | RESTful web services enabling computa... |
| gtopdb.targets.csv ⚠ | GtoPdb Targets and Families | targets_and_families.csv | Product | csv | Complete list of drug targets and the... |
| gtopdb.ligands.csv ⚠ | GtoPdb Ligands Dataset | ligands.csv | Product | csv | Complete list of ligands including dr... |
| gtopdb.interactions.csv ⚠ | GtoPdb Interactions Dataset | interactions.csv | Product | csv | Comprehensive dataset of all interact... |
| gtopdb.approved_drugs.csv ⚠ | GtoPdb Approved Drugs Dataset | approved_drug_detailed_interactions.csv | Product | csv | Detailed interactions list for approv... |
| gtopdb.download.sdf ⚠ | GtoPdb Ligand SDF File | all_ligands.sdf | Product | sdf | SDF file containing chemical structur... |
| gtopdb.download.rdf ⚠ | GtoPdb RDF Dataset | gtp-rdf.n3 | Product | rdfxml | RDF/linked data format of the GtoPdb ... |
| gtopdb.database ⚠ | GtoPdb Full Database | public_iuphardb_v2025.1.zip | Product | ❔ | Complete PostgreSQL database dump of ... |
| gtopdb.immunopharmacology | Guide to IMMUNOPHARMACOLOGY | index.jsp | GraphicalInterface | ❔ | An extension of the Guide to PHARMACO... |
| gtopdb.malaria | Guide to MALARIA PHARMACOLOGY | index.jsp | GraphicalInterface | ❔ | A specialized portal providing optimi... |
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| rtx-kg2.graph.nodes | RTX-KG2.10.1c KGX JSONL Nodes | kg2c-2.10.1-v1.0-nodes.jsonl.gz (359.1 MB) | GraphProduct | kgx-jsonl | Nodes for KGX distribution of the RTX... |
| rtx-kg2.graph.edges | RTX-KG2.10.1c KGX JSONL Edges | kg2c-2.10.1-v1.0-edges.jsonl.gz (1.7 GB) | GraphProduct | kgx-jsonl | Edges for KGX distribution of the RTX... |
| rtx-kg2.neo4j | RTX-KG2 Neo4j | arax.ncats.io | ProgrammingInterface | ❔ | Neo4j distribution of the RTX-KG2 as ... |
| automat.gtopdb | gtopdb_automat | 0ea6074c824c2236 | GraphProduct | kgx-jsonl | GtoPdb Automat |
| translator.gtopdb.graph | Translator GToPdb KGX Graph | latest | GraphProduct | kgx-jsonl | KGX JSONL graph package for GToPdb di... |
| translator.translator_kg.graph | Translator Aggregate KGX Graph | latest | GraphProduct | kgx-jsonl | Aggregated KGX JSONL graph package co... |
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) is an expert-curated resource providing authoritative information on drug targets and the substances that act on them. It’s developed as a collaboration between the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS).
GtoPdb serves as a “one-stop shop” portal to pharmacological information, containing quantitative data on drug targets and the prescription medicines and experimental drugs that act on them. The database focuses on interactions between human proteins and their ligands, with information primarily derived from high-quality pharmacological and medicinal chemistry literature.
The database is accessible through multiple means:
GtoPdb covers all major pharmacological target classes:
The database includes detailed information on:
GtoPdb follows a regular release cycle, with major updates several times per year. The database is continually growing with new target and ligand entries, focusing particularly on targets of current and potential future approved drugs.
Created: May 30, 2025 | Last modified: February 20, 2026