is an Aggregator.
HCOP (HGNC Comparison of Orthology Predictions) is an HGNC tool and dataset that integrates orthology assertions between human genes and genes of 19 other species (chimp, macaque, mouse, rat, dog, cat, horse, cattle, pig, opossum, platypus, chicken, anole lizard, Xenopus, zebrafish, C. elegans, Drosophila, S. cerevisiae, and S. pombe) from eggNOG, Ensembl Compara, HGNC, HomoloGene, Inparanoid, NCBI Gene orthology, OMA, OrthoDB, OrthoMCL, PANTHER, PhylomeDB, PomBase, TreeFam, and ZFIN. Each predicted ortholog pair lists the supporting sources, so the number of concurring databases indicates reliability, and gene data come from the relevant nomenclature and model organism databases. Data are updated weekly.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| hcop.web | HCOP Search | hcop | Graphical Interface | http | HCOP web search for orthologs of one ... |
| hcop.all-seven-column | HCOP All Species Orthologs (7 column) | human_all_hcop_seven_column.txt.gz (25.2 MB) | Mapping | tsv | All human ortholog assertions from HC... |
| hcop.all-sixteen-column | HCOP All Species Orthologs (16 column) | human_all_hcop_sixteen_column.txt.gz (39.9 MB) | Mapping | tsv | All human ortholog assertions from HC... |
| hcop.species-downloads | HCOP Per-species Bulk Downloads | tsv | Product | http | HCOP bulk downloads page with pre-com... |
| hcop.docs | HCOP Help | hcop | Documentation | http | HCOP help page describing search usag... |
HCOP (HGNC Comparison of Orthology Predictions) is a tool from the HUGO Gene Nomenclature Committee (HGNC) that combines orthology predictions from many databases into one view. It was first built for human and mouse and now covers human plus 19 other species. For each predicted ortholog pair, HCOP lists the databases that support it, so the number of agreeing sources gives a measure of confidence.
Orthology assertions are imported from eggNOG, Ensembl Compara, HGNC, HomoloGene, Inparanoid, NCBI Gene orthology, OMA, OrthoDB, OrthoMCL, PANTHER, PhylomeDB (phylome 514), PomBase, TreeFam, and ZFIN. Not every source covers every species; the HCOP help page lists versions and species coverage for each source.
Gene symbols, names, locus types, and locations come from Ensembl, HGNC, MGI, NCBI Gene, PomBase, RGD, SGD, VGNC, WormBase, Xenbase, and ZFIN. For species without a nomenclature committee (chimp, macaque, dog, horse, cattle, pig, opossum, platypus) or without usable gene data (anole lizard), gene data are taken from NCBI Gene, or from Ensembl when no NCBI Gene ID can be mapped. A weekly pipeline checks each source for new data and updates HCOP.
https://storage.googleapis.com/public-download-files/hcop/): per-species files (human vs. one species, 6 or 15 columns) and all-species files (7 or 16 columns).HGNC data, including HCOP, are released under the Creative Commons CC0 public domain dedication. Attribution is requested but not required.
Created: October 19, 2026 | Last modified: October 19, 2026