is a Data Source.
HOCOMOCO (HOmo sapiens COmprehensive MOdel COllection) is a curated database of transcription factor (TF) binding models, primarily position weight matrices (PWMs), for human and mouse. The models are derived from large-scale ChIP-Seq and HT-SELEX experiments and are manually curated, benchmarked, and annotated with quality ratings and recommended score thresholds. HOCOMOCO covers over a thousand human and mouse TFs, including secondary motif subtypes, and is a widely used upstream source for downstream regulatory resources such as DoRothEA.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| hocomoco.core-pwms ⚠ | HOCOMOCO v11 Core Human Mononucleotide PWMs | HOCOMOCOv11_core_pwms_HUMAN_mono.txt | Product | txt | HOCOMOCO v11 core collection human mo... |
| hocomoco.full-pwms ⚠ | HOCOMOCO v11 Full Human Mononucleotide PWMs | HOCOMOCOv11_full_pwms_HUMAN_mono.txt | Product | txt | HOCOMOCO v11 full collection human mo... |
| hocomoco.downloads | HOCOMOCO Downloads | downloads_v11 | Product | http | HOCOMOCO download portal with PWM/PCM... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| dorothea.graph | DoRothEA Regulon Graph | v1.0.0 | GraphProduct | ❔ | had primary source | Core TF–target regulon knowledge grap... |
HOCOMOCO (HOmo sapiens COmprehensive MOdel COllection) is a manually curated collection of transcription factor (TF) binding models for human and mouse. The models are represented primarily as position weight matrices (PWMs) and position count matrices (PCMs), built from integrated ChIP-Seq and HT-SELEX data and benchmarked for quality.
HOCOMOCO models are used for motif scanning, regulatory sequence analysis, and as an upstream source of TF binding evidence for downstream resources such as DoRothEA.
HOCOMOCO is distributed under the WTFPL; the authors note it may alternatively be treated as CC-BY.
Created: June 18, 2026 | Last modified: June 18, 2026