is a Data Source.
HumanCyc is an encyclopedic reference on human metabolic pathways, the human genome, and human metabolites. It is a Pathway/Genome Database (PGDB) within the BioCyc collection maintained by SRI International, computationally predicting the metabolic network of Homo sapiens and integrating genes, enzymes, reactions, compounds, and pathways with tools for omics analysis.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| humancyc.portal | HumanCyc Web Portal | humancyc.org | GraphicalInterface | http | Web interface for browsing and search... |
| humancyc.downloads | HumanCyc Data Downloads | download.shtml | Product | mixed | Downloadable HumanCyc Pathway/Genome ... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| pathwaycommons.biopax | Integrated BioPAX Model | pc-biopax.owl.gz (1.6 GB) | Product | biopax | was derived from | PC v14 integrated BioPAX Level 3 unif... |
| pathwaycommons.downloads | Pathway Commons Data Downloads | v14 | Product | mixed | was derived from | Download directory for Pathway Common... |
| pathwaycommons.sif | SIF Network Format | pc-hgnc.sif.gz (9.4 MB) | Product | sif | was derived from | PC v14 Simple Interaction Format netw... |
| pathwaycommons.gmt | GMT Gene Set Format | pc-hgnc.gmt.gz (256.4 KB) | Product | ❔ | was derived from | PC v14 Gene Matrix Transposed gene se... |
| pathwaycommons.txt | Extended SIF TXT Format | pc-hgnc.txt.gz (110.3 MB) | Product | txt | was derived from | PC v14 tab-delimited extended SIF nod... |
HumanCyc is an encyclopedic reference on human metabolic pathways, the human genome, and human metabolites. Built as a Pathway/Genome Database (PGDB) within the BioCyc collection, it was originally generated by computationally predicting the metabolic pathway complement of the human genome and has since been curated and maintained by SRI International.
HumanCyc is distributed under the BioCyc subscription model, which offers tiered access including free trials, classroom use, academic licenses, and commercial licensing.
Romero P, Wagg J, Green ML, et al. Computational prediction of human metabolic pathways from the complete human genome. Genome Biology (2005) 6:R2. doi:10.1186/gb-2004-6-1-r2
Created: June 03, 2026 | Last modified: June 05, 2026