humannet

is a Data Source.

HumanNet is a probabilistic functional gene network for Homo sapiens that integrates genomic and proteomic data from multiple sources to predict functional relationships between genes. The network uses a modified Bayesian integration approach to combine evidence from diverse data types including protein-protein interactions, gene co-expression, phylogenetic profiling, and literature mining. HumanNet provides confidence scores for gene-gene functional linkages and can be used for gene function prediction, disease gene prioritization, and pathway analysis.

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Domains

genomics, systems biology, biomedical, biological systems

License

CC BY-SA 4.0

Homepage

humannet

Repository

Unknown

Infores ID

Unknown

FAIRsharing ID

Unknown

Product Summary

Products

From this Resource
ID Name URL Category Format Description
humannet.web HumanNet Web Interface humannetv3 GraphicalInterface http HumanNet v3 web interface for selecti...
humannet.network HumanNet Network File HumanNet-XC.tsv.gz (11.7 MB) GraphProduct tsv HumanNet-XC v3 functional gene networ...
humannet.network.symbol HumanNet Network File (Gene Symbols) HumanNet-XC.symbol.tsv.gz (13.3 MB) GraphProduct tsv HumanNet-XC v3 functional gene networ...
From other Resources
ID Name URL Category Format Relation Description
pharmkg.graph PharmKG graph 4077338 GraphProduct ❔ had primary source Cleaned benchmark graph (PharmKG-8k) ...

Details

HumanNet

Overview

HumanNet is a probabilistic functional gene network for Homo sapiens that integrates genomic and proteomic data from multiple sources to predict functional relationships between genes.

Using a modified Bayesian integration approach, HumanNet combines evidence from diverse data types including protein-protein interactions, gene co-expression patterns, phylogenetic profiling, and biomedical literature to construct a comprehensive functional network with confidence-weighted gene-gene linkages.

Key Features

  • Comprehensive Coverage: HumanNet-XC v3 covers 18,462 genes in the download table
  • Multi-Source Integration: Combines protein interactions, co-expression, phylogeny, and literature
  • Confidence Scores: Probabilistic scores for functional linkages
  • Multiple Network Tiers: PI, FN, and XC networks for protein interaction, functional association, and co-citation-extended analyses
  • Web Tools: Interactive visualization and analysis tools

Research Applications

  • Gene function prediction
  • Disease gene prioritization
  • Pathway analysis and enrichment
  • Systems biology studies
  • Network-based drug target discovery
  • Functional module identification

Products

HumanNet Web Interface

Interactive platform for querying genes, visualizing network neighborhoods, and performing gene function predictions.

HumanNet Network File

Downloadable network files containing gene-gene functional linkages with confidence scores in various formats.

Publications

Domains

  • Genomics
  • Systems Biology
  • Biomedical
  • Biological Systems

Taxon Coverage

Human (NCBITaxon:9606)

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Created: November 05, 2025 | Last modified: June 02, 2026