innatedb

is a Data Source.

InnateDB is a publicly available database of genes, proteins, experimentally-verified interactions and signaling pathways involved in the innate immune response of humans, mice and bovines to microbial infection, with over 18,780 manually curated interactions and integrated bioinformatics and visualization tools for systems-level analysis.

Domains

immunology, biological systems, systems biology

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infores:innatedb

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Product Summary

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innatedb.portal InnateDB Web Portal www.innatedb.com GraphicalInterface http Web interface for searching and analy...
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Details

InnateDB

Overview

InnateDB is a publicly available knowledge resource dedicated to the innate immune response. It provides comprehensive information about genes, proteins, experimentally-verified molecular interactions, and signaling pathways involved in innate immunity across humans, mice, and bovines. The database integrates data from major public databases with extensive manually-curated content to create a centralized resource for innate immunity research.

Key Features

  • Extensive Manual Curation: Over 18,780 interactions manually curated by the InnateDB team
  • Multi-Species Coverage: Data for humans, mice, and bovines
  • Integrated Data: Combines known interactions and pathways from major public databases
  • Systems Biology Tools: Integrated bioinformatics and visualization tools for systems-level analysis
  • Comprehensive Content: Genes, proteins, protein-protein interactions, and signaling pathways

Content Coverage

Molecular Entities

  • Innate immunity-related genes
  • Protein annotations
  • Experimentally-verified protein-protein interactions
  • Signaling pathways

Analysis Capabilities

  • Gene Ontology analysis
  • Pathway analysis
  • Network analysis
  • Protein-protein interaction networks
  • Integration with visualization tools

Applications

  • Immunology Research: Understanding innate immune responses to infection
  • Systems Biology: Systems-level analysis of immune signaling networks
  • Drug Discovery: Identifying potential therapeutic targets in innate immunity
  • Comparative Immunology: Cross-species analysis of immune responses
  • Pathway Analysis: Studying signaling cascades in immune responses
  • Network Biology: Analyzing interaction networks in immunity

Development Team

InnateDB is developed jointly by:

  • Brinkman Laboratory - Simon Fraser University, British Columbia, Canada
  • Hancock Laboratory - University of British Columbia, Vancouver, British Columbia
  • Lynn EMBL Australia Group - South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia

Funding

Supported by:

  • Allergen NCE
  • EMBL Australia
  • Previously: Genome Canada, Genome BC, Foundation for NIH (Grand Challenges in Global Health), Teagasc

Data Licensing

  • InnateDB curated interactions: Design Science License
  • Other data: Licensed under terms of originating databases

Citation

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucleic Acids Research (2013) 41 (D1): D1228-D1233.

Information Resource ID

This resource has the Information Resource identifier: infores:innatedb

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Created: October 30, 2025 | Last modified: November 26, 2025