intact

is an Aggregator.

It is part of the BER collection.

IntAct is an open, curated molecular interaction database maintained at EMBL‑EBI. It aggregates experimentally-derived interaction evidence from literature curation and direct submissions, and distributes data in PSI‑MI XML and MITAB formats along with curated datasets and documentation.

License

CC BY 4.0

Homepage

intact

Repository

GitHub

Infores ID

infores:intact

FAIRsharing ID

Unknown

Product Summary

Products

From this Resource
ID Name URL Category Format Description
intact.portal IntAct Portal home Graphical Interface http Web portal for browsing, searching, a...
intact.api IntAct Web Service ws Programming Interface http IntAct web service and URL-based prog...
intact.ftp.psi25 IntAct PSI-MI XML 2.5 psi25 Product psi_mi_xml IntAct data in PSI-MI XML 2.5 format ...
intact.ftp.psi30 IntAct PSI-MI XML 3.0 psi30 Product psi_mi_xml IntAct data in PSI-MI XML 3.0 format ...
intact.ftp.psimitab IntAct PSI-MI MITAB 2.7 psimitab Product psi_mi_mitab IntAct data in PSI-MI MITAB format (d...
intact.ftp.psimitab.all IntAct MITAB Archive intact.zip (807.1 MB) Product psi_mi_mitab Entire MITAB export of the database a...
intact.datasets IntAct Datasets datasets Product http Curated and computational datasets (d...
intact.docs.user-guide IntAct User Guide user-guide Documentation http User guide and documentation for sear...
From other Resources
ID Name URL Category Format Relation Description
bioteque.embeddings Bioteque Embeddings embeddings Product mixed had primary source Network embeddings of the Bioteque gr...
clinicalkg.graph CKG Graph Dump 1 Graph mixed had primary source Neo4j database dump of the Clinical K...
epigraphdb.graph EpiGraphDB Graph Database graph-database Graph neo4j had primary source Integrated graph knowledge base combi...
rnacentral.portal RNAcentral Portal rnacentral.org Graphical Interface http had primary source Web portal for searching and browsing...
rnacentral.api RNAcentral REST API api Programming Interface http had primary source REST API for programmatic access to R...
rnacentral.ftp RNAcentral FTP Archive RNAcentral Product http had primary source FTP archive with current and archived...
rnacentral.public-db RNAcentral Public Postgres Database public-database Data Model postgres had primary source Public PostgreSQL database for direct...
automat.intact intact_automat e5b936f966a02c2c Graph kgx-jsonl had primary source IntAct Automat
cancer-genome-interpreter.clinicalkg.graph CKG Graph Dump 1 Graph mixed had primary source Neo4j database dump of the Clinical K...
genecards.protein.interactions ⚠ GeneCards Protein Interactions www.genecards.org Product http had primary source Protein interaction data aggregated f...
irefindex.database iRefIndex Database ❔ Product psi_mi_mitab had primary source Historical consolidated protein inter...
translator.intact.graph Translator IntAct KGX Graph latest Graph kgx-jsonl had primary source KGX JSONL graph package for IntAct di...
unibiomap.links UniBioMap Graph Links unibiomap.links.csv (1.3 GB) Graph csv had primary source Core UniBioMap graph edges file.
unibiomap.auxs UniBioMap Graph Auxiliaries unibiomap.auxs.tsv (563.9 MB) Graph tsv had primary source Auxiliary UniBioMap graph annotations...
unibiomap.pred UniBioMap Predicted Graph unibiomap.pred.csv (2.3 GB) Graph csv had primary source Predicted UniBioMap graph edges with ...
unibiomap.pred.full UniBioMap Predicted Graph (Full) unibiomap.pred.full.csv (5.9 GB) Graph csv had primary source Full unfiltered UniBioMap predicted g...
string.protein.links STRING Protein Links protein.links.v12.0.txt.gz (128.7 GB) Graph txt had primary source protein network data (full network, s...
string.protein.links.detailed STRING Protein Links Detailed protein.links.detailed.v12.0.txt.gz (189.6 GB) Graph txt had primary source protein network data (full network, i...
string.protein.links.full STRING Protein Links Full protein.links.full.v12.0.txt.gz (199.6 GB) Graph txt had primary source protein network data (full network, i...
string.protein.physical.links STRING Protein Physical Links protein.physical.links.v12.0.txt.gz (11.1 GB) Graph txt had primary source protein network data (physical subnet...
string.protein.physical.links.detailed STRING Protein Physical Links Detailed protein.physical.links.detailed.v12.0.txt.gz (13.8 GB) Graph txt had primary source protein network data (physical subnet...
string.protein.physical.links.full STRING Protein Physical Links Full protein.physical.links.full.v12.0.txt.gz (14.5 GB) Graph txt had primary source protein network data (physical subnet...
string.cog.links STRING COG Links COG.links.v12.0.txt.gz (176.8 MB) Graph txt had primary source association scores between orthologou...
string.cog.links.detailed STRING COG Links Detailed COG.links.detailed.v12.0.txt.gz (238.7 MB) Graph txt had primary source association scores (incl. subscores p...
string.database STRING Database Network Schema network_schema.v12.0.sql.gz (262.2 GB) Graph postgres had primary source full database, part II: the networks ...
translator.translator_kg.graph Translator Aggregate KGX Graph latest Graph kgx-jsonl had primary source Aggregated KGX JSONL graph package co...
ckg.graph CKG Graph Database Dump 1 Graph neo4j had primary source Graph database dump and additional re...
afcs.intact.mitab AFCS IntAct MITAB Dataset AFCS.zip (704.1 KB) Product psi_mi_mitab was influenced by IntAct-hosted AFCS protein interactio...
imex.portal IMEx Portal www.imexconsortium.org Graphical Interface http had primary source Search interface for the shared IMEx ...
imex.downloads IMEx Downloads downloads Product psi_mi_mitab had primary source IMEx interaction downloads distribute...
drkg.graph DRKG graph drkg.tar.gz (206.6 MB) Graph mixed had primary source DRKG graph files, including a TSV of ...
rtx-kg2.graph.nodes RTX-KG2.10.1c KGX JSONL Nodes kg2c-2.10.1-v1.0-nodes.jsonl.gz (359.1 MB) Graph kgx-jsonl had primary source Nodes for KGX distribution of the RTX...
rtx-kg2.graph.edges RTX-KG2.10.1c KGX JSONL Edges kg2c-2.10.1-v1.0-edges.jsonl.gz (1.7 GB) Graph kgx-jsonl had primary source Edges for KGX distribution of the RTX...
rtx-kg2.neo4j RTX-KG2 Neo4j arax.ncats.io Programming Interface http had primary source Neo4j distribution of the RTX-KG2 as ...
genemania.networks GeneMANIA Interaction Network Archive current Graph txt was derived from Downloadable GeneMANIA interaction ne...
hippie.current.tab HIPPIE Current TAB Dataset hippie_current.txt (132.3 MB) Product tsv was derived from Current HIPPIE v2.4 interaction datas...
hippie.current.mitab HIPPIE Current PSI-MI TAB Dataset HIPPIE-current.mitab.txt (245.1 MB) Product psi_mi_mitab was derived from Current HIPPIE v2.4 interaction datas...
hpidb.mitab ⚠ HPIDB PSI-MITAB Dataset hpidb.igbb.msstate.edu Product psi_mi_mitab was derived from Downloadable HPIDB host-pathogen inte...
humannet.network HumanNet Network File HumanNet-XC.tsv.gz (11.7 MB) Graph tsv was derived from HumanNet-XC v3 functional gene networ...
humannet.network.symbol HumanNet Network File (Gene Symbols) HumanNet-XC.symbol.tsv.gz (13.3 MB) Graph tsv was derived from HumanNet-XC v3 functional gene networ...
iid.human_annotated_ppis IID Human Annotated PPIs human_annotated_PPIs.txt.gz (144.0 MB) Graph tsv was derived from IID annotated human protein-protein i...
iid.mouse_annotated_ppis IID Mouse Annotated PPIs mouse_annotated_PPIs.txt.gz (38.2 MB) Graph tsv was derived from IID annotated mouse protein-protein i...
mint.mitab.all ⚠ MINT MITAB Full Dataset * Product psi_mi_mitab was influenced by Complete MINT dataset in PSI-MI MITAB...
mint.mitab.human ⚠ MINT Human Interactions species:human Product psi_mi_mitab was influenced by Human protein interactions from MINT ...
mint.mitab.mouse ⚠ MINT Mouse Interactions species:mouse Product psi_mi_mitab was influenced by Mouse protein interactions from MINT ...
mint.mitab.drosophila ⚠ MINT Drosophila Interactions species:fruit%20fly Product psi_mi_mitab was influenced by Drosophila melanogaster protein inter...
mint.mitab.yeast ⚠ MINT Yeast Interactions species:yeast Product psi_mi_mitab was influenced by Saccharomyces cerevisiae protein inte...
mint.psicquic MINT PSICQUIC Web Service webservices Programming Interface http was influenced by PSICQUIC SOAP and REST web services f...
pathwaycommons.biopax Integrated BioPAX Model pc-biopax.owl.gz (1.6 GB) Product biopax was derived from PC v14 integrated BioPAX Level 3 unif...
proteomehd.intact_interactions ProteomeHD IntAct Interactions IntAct_interactions.7z (1.3 MB) Product csv was derived from Pre-processed human IntAct interactio...
pathwaycommons.downloads Pathway Commons Data Downloads v14 Product mixed was derived from Download directory for Pathway Common...
pathwaycommons.sif SIF Network Format pc-hgnc.sif.gz (9.4 MB) Product sif was derived from PC v14 Simple Interaction Format netw...
pathwaycommons.gmt GMT Gene Set Format pc-hgnc.gmt.gz (256.4 KB) Product tsv was derived from PC v14 Gene Matrix Transposed gene se...
pathwaycommons.txt Extended SIF TXT Format pc-hgnc.txt.gz (110.3 MB) Product txt was derived from PC v14 tab-delimited extended SIF nod...
biobtree.api BioBTree REST API api Programming Interface http had primary source REST API for searching identifiers an...
genecards.web.interface GeneCards Web Interface www.genecards.org Graphical Interface http had primary source Web-based interface for searching and...
biobtree.graph.human-subgraph BioBTree Knowledge Graph - Human Subgraph (KGX) 20816742 Graph kgx had primary source Human-scoped, Neo4j-ready subgraph of...
kg-covid-19.graph ⚠ KG-COVID-19 graph kg-covid-19 Graph kgx had primary source KGX nodes and edges for KG-COVID-19

Details

IntAct

Overview

IntAct is a curated molecular interaction database, aggregating experimental evidence from the literature and direct submissions and distributing data in PSI‑MI XML and MITAB formats. It is part of the IMEx consortium and a Global Core Biodata Resource.

Access

  • Portal: browse and search interactions via the IntAct web interface
  • API: programmatic access through the IntAct web service and URL-based interface
  • FTP: bulk downloads in PSI‑MI XML (2.5, 3.0) and MITAB (2.7)
  • Datasets: curated and computational datasets with themed collections
  • Documentation: user guide covering data sources, formats, export, and submission

Citation

Please cite IntAct and any specific datasets used, and refer to the CC BY 4.0 license terms for data reuse.

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Created: July 08, 2025 | Last modified: September 23, 2026