KiNet

Overview

KiNet is a web portal that aggregates and visualizes the network of interactions between protein kinases and their substrates in the human genome. The platform provides multiple ways to select and explore sets of proteins, displaying known kinase-substrate interactions with phosphorylation site, evidence, and source database details. The archived Zenodo dataset was deposited under the KinAce name.

Data Sources

KinAce integrates data from multiple authoritative sources:

• Interactions: PhosphoSitePlus, iPTMnet, EPSD
• Kinase groups: KinHub, CORAL, Dark Kinase Knowledgebase
• Protein names: UniProt
• Gene symbols: HGNC
• Pathways: KEGG
• Protein domains: InterPro

Key Features

Multiple Access Points

• Search by protein
• Browse by pathway
• Filter by domain
• Create custom protein sets

Visualization Capabilities

• Network views of kinase-substrate relationships
• Phosphorylation site mapping
• Kinase family groupings
• Interactive exploration tools

Data Types

• Proteins: Human proteome coverage
• Pathways: KEGG pathway integration
• Domains: InterPro domain annotations
• Interactions: Experimentally validated phosphorylation events

Scope and Coverage

• Species: Human (Homo sapiens, NCBITaxon:9606)
• Focus: Protein kinases and their substrates
• Data types: Phosphorylation sites, kinase-substrate interactions
• Integration: Multiple complementary data sources

Use Cases

• Identifying kinase substrates for target proteins
• Exploring kinase signaling networks
• Studying phosphorylation cascades
• Drug target identification
• Systems biology analysis of phosphorylation networks

Information Resource ID

This resource has the Information Resource identifier: infores:kinace