kinhub

KinHub

KinHub is a comprehensive web-based resource for human protein kinases, centered around KinMap, an interactive visualization tool for the human kinome tree. The resource integrates data from multiple freely-available sources including ChEMBL, the Protein Data Bank, and the Center for Therapeutic Target Validation platform.

KinMap: Interactive Kinome Tree Viewer

KinMap facilitates the interactive exploration of the human kinome by linking biochemical, structural, and disease association data to phylogenetic relationships:

• Compound profiling data integration: Visualize kinase inhibitor selectivity and binding profiles
• Structural feature annotation: Display structural characteristics of kinases mapped onto the kinome tree
• Disease association mapping: Connect kinase functions to therapeutic indications
• Unified naming scheme: Recognizes alternative kinase names and links them to standardized nomenclature

Key Features

Data Integration

• ChEMBL: Bioactivity data for kinase inhibitors
• Protein Data Bank (PDB): Structural information for kinases
• Center for Therapeutic Target Validation: Disease association and drug target data
• Proprietary data support: Users can complement public data with their own datasets

Input/Output Formats

• Multiple input formats supported for kinase lists and activity data
• High-quality annotated image generation of kinome trees
• Data exchange capabilities for scientific communications
• Interactive annotations that can be saved and shared

Applications

1. Drug repurposing: Uncovering new therapeutic indications for known kinase inhibitors
2. Drug development prioritization: Identifying promising kinases for drug development efforts
3. Kinase selectivity analysis: Comparing inhibitor profiles across the kinome
4. Target validation: Linking kinase functions to disease phenotypes

Human Protein Kinases Database

KinHub provides a comprehensive list of human protein kinases with:

• Standardized nomenclature based on Manning et al. 2002 classification
• Phylogenetic relationships within kinase families
• Alternative names and synonyms for each kinase
• Cross-references to major protein databases

Manning Kinome Classification

The human kinome comprises approximately 518 protein kinases classified into major groups:

• AGC group: PKA, PKG, PKC families
• CAMK group: Calcium/calmodulin-dependent kinases
• CK1 group: Casein kinase 1 family
• CMGC group: CDK, MAPK, GSK3, CLK families
• STE group: Homologs of yeast Sterile kinases
• TK group: Tyrosine kinases
• TKL group: Tyrosine kinase-like kinases
• Atypical kinases: RIO, PIKK families
• Other: Unclassified protein kinases

Visualization Capabilities

KinMap enables users to:

• Generate phylogenetic tree views of the entire human kinome
• Highlight specific kinases or groups based on query criteria
• Color-code kinases by activity, selectivity, or other properties
• Overlay structural information (e.g., presence of crystal structures)
• Display disease associations and clinical relevance
• Export high-resolution images for publications

Data Sources and Updates

The resource is maintained with preprocessed data from:

• ChEMBL: Updated kinase bioactivity database
• PDB: Current structural information for kinases
• CTTV (now Open Targets): Disease-target associations
• UniProt: Protein sequence and functional annotations
• Manning kinome tree: Phylogenetic classification framework