kinomescan

is a Data Source.

KINOMEscan is a biochemical kinase profiling assay that measures drug binding using a panel of approximately 440 purified kinases. The HMS LINCS Project provides a comprehensive table of all small molecules in the HMS LINCS collection that have been profiled by KINOMEscan, with links to raw binding data.

Domains

drug discovery, pharmacology, biomedical

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Homepage

kinomescan

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infores:kinomescan

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Product Summary

Products

From this Resource
ID Name URL Category Format Description
kinomescan.portal KINOMEscan Data Portal kinomescan GraphicalInterface http Web interface providing searchable ta...
kinomescan.spreadsheet KINOMEscan Datasets Spreadsheet HMS-LINCS_KinomeScan_Datasets_2018-01-18.xlsx (17.5 KB) DocumentationProduct ❔ Excel spreadsheet containing HMS LINC...

Details

KINOMEscan

Overview

KINOMEscan is a biochemical kinase profiling assay technology that measures drug binding using a panel of approximately 440 purified kinases. The data resource is maintained by the HMS LINCS (Harvard Medical School Library of Integrated Network-based Cellular Signatures) Project. The assay provides comprehensive profiling of small molecule compounds against a large kinase panel, enabling drug discovery and selectivity profiling studies.

Data Content

The HMS LINCS KINOMEscan data collection includes:

  • Compound Coverage: Small molecules from the HMS LINCS collection that have been profiled by KINOMEscan
  • Kinase Panel: Approximately 440 purified kinases representing a broad coverage of the human kinome
  • Binding Data: Raw binding data for each compound-kinase interaction
  • Compound Information: HMSL identifiers, LSM numbers, common names, and synonyms for each profiled compound

The data includes kinase inhibitors, multi-kinase inhibitors, and other bioactive small molecules commonly used in drug discovery and chemical biology research.

Key Features

  • Comprehensive Kinase Coverage: ~440 kinases representing diverse families
  • Biochemical Assay: Direct measurement of compound binding to purified kinases
  • Searchable Data: Web interface with compound names and identifiers
  • Downloadable Datasets: Excel spreadsheet format for offline analysis
  • HMS LINCS Integration: Part of the broader HMS LINCS data ecosystem

Access Methods

  1. Web Interface: Browse and search KINOMEscan data through the HMS LINCS portal
  2. Spreadsheet Download: Excel file containing complete dataset information and links (last updated January 18, 2018)

Data Format

  • Online: HTML table with compound information and data links
  • Downloadable: Microsoft Excel (.xlsx) format

Use Cases

  • Drug Discovery: Kinase inhibitor profiling and selectivity assessment
  • Target Validation: Understanding kinase inhibitor specificity
  • Polypharmacology Studies: Identifying off-target kinase interactions
  • Structure-Activity Relationships: Correlating compound structure with kinase binding profiles
  • Chemical Biology: Tool compound characterization

Management

The KINOMEscan data resource is managed and curated by the HMS LINCS Project at Harvard Medical School.

  • HMS LINCS Database: https://lincs.hms.harvard.edu/db/
  • HMS LINCS Data Exploration Tools: https://lincs.hms.harvard.edu/explore/
  • HMS LINCS Publications: https://lincs.hms.harvard.edu/about/publications/

Last Update

The downloadable spreadsheet was last updated on January 18, 2018.

Is this information incorrect or incomplete? Request an update.

Created: October 30, 2025 | Last modified: October 31, 2025