kinomescan

is a Data Source.

KINOMEscan is a biochemical kinase profiling assay that measures drug binding using a panel of approximately 440 purified kinases. The HMS LINCS Project provides a comprehensive table of all small molecules in the HMS LINCS collection that have been profiled by KINOMEscan, with links to raw binding data.

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Domains

drug discovery, pharmacology, biomedical, high-throughput screening

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Homepage

kinomescan

Repository

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External IDs
  • Infores: infores:kinomescan

Product Summary

Products

From this Resource
ID Name URL Category Format Description
kinomescan.portal KINOMEscan Data Portal kinomescan Graphical Interface http Web interface providing searchable ta...
kinomescan.spreadsheet KINOMEscan Datasets Spreadsheet HMS-LINCS_KinomeScan_Datasets_2018-01-18.xlsx (17.5 KB) Documentation xlsx Excel spreadsheet containing HMS LINC...
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Details

KINOMEscan

Overview

KINOMEscan is a biochemical kinase profiling assay technology that measures drug binding using a panel of approximately 440 purified kinases. The data resource is maintained by the HMS LINCS (Harvard Medical School Library of Integrated Network-based Cellular Signatures) Project. The assay provides comprehensive profiling of small molecule compounds against a large kinase panel, enabling drug discovery and selectivity profiling studies.

Data Content

The HMS LINCS KINOMEscan data collection includes:

  • Compound Coverage: Small molecules from the HMS LINCS collection that have been profiled by KINOMEscan
  • Kinase Panel: Approximately 440 purified kinases representing a broad coverage of the human kinome
  • Binding Data: Raw binding data for each compound-kinase interaction
  • Compound Information: HMSL identifiers, LSM numbers, common names, and synonyms for each profiled compound

The data includes kinase inhibitors, multi-kinase inhibitors, and other bioactive small molecules commonly used in drug discovery and chemical biology research.

Key Features

  • Comprehensive Kinase Coverage: ~440 kinases representing diverse families
  • Biochemical Assay: Direct measurement of compound binding to purified kinases
  • Searchable Data: Web interface with compound names and identifiers
  • Downloadable Datasets: Excel spreadsheet format for offline analysis
  • HMS LINCS Integration: Part of the broader HMS LINCS data ecosystem

Access Methods

  1. Web Interface: Browse and search KINOMEscan data through the HMS LINCS portal
  2. Spreadsheet Download: Excel file containing complete dataset information and links (last updated January 18, 2018)

Data Format

  • Online: HTML table with compound information and data links
  • Downloadable: Microsoft Excel (.xlsx) format

Use Cases

  • Drug Discovery: Kinase inhibitor profiling and selectivity assessment
  • Target Validation: Understanding kinase inhibitor specificity
  • Polypharmacology Studies: Identifying off-target kinase interactions
  • Structure-Activity Relationships: Correlating compound structure with kinase binding profiles
  • Chemical Biology: Tool compound characterization

Management

The KINOMEscan data resource is managed and curated by the HMS LINCS Project at Harvard Medical School.

  • HMS LINCS Database: https://lincs.hms.harvard.edu/db/
  • HMS LINCS Data Exploration Tools: https://lincs.hms.harvard.edu/explore/
  • HMS LINCS Publications: https://lincs.hms.harvard.edu/about/publications/

Last Update

The downloadable spreadsheet was last updated on January 18, 2018.

Is this information incorrect or incomplete? Request an update.

Created: October 30, 2025 | Last modified: September 23, 2026