is a Data Source.
The Library of Integrated Network-based Cellular Signatures (LINCS) is a comprehensive collection of data that catalogs how human cells globally respond to chemical, genetic, and disease perturbations. It aims to better understand human disease and advance the development of new therapies by assembling an integrated picture of the range of responses of human cells exposed to many perturbations.
biomedical, drug discovery, systems biology, genomics, proteomics, precision medicine
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infores:lincs
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| lincs.portal | LINCS Data Portal 2.0 | home | GraphicalInterface | ❔ | Web interface that allows users to ex... |
| lincs.api | LINCS API | swagger-ui.html# | ProgrammingInterface | ❔ | API for programmatic access to LINCS ... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| ubkg.neo4j | UBKG Neo4j Docker Distribution | ubkg-downloads.xconsortia.org | GraphProduct | ❔ | had primary source | Turnkey neo4j distributions that depl... |
| ubkg.csv | UBKG Ontology CSV Files | ubkg-downloads.xconsortia.org | GraphProduct | csv | had primary source | Ontology CSV files that can be import... |
| bioteque.embeddings | Bioteque Embeddings | embeddings | Product | ❔ | had primary source | Network embeddings of the Bioteque gr... |
| prokn.lincs.compound.in_similarity_relationship_with.compound.edges | ProKN LINCS Compound Similarity Edges | DDKG_LINCS.Compound.IN_SIMILARITY_RELATIONSHIP_WITH.Compound.edges.csv (5.9 MB) | GraphProduct | csv | had primary source | LINCS compound similarity edges |
| prokn.lincs.compound.negatively_regulates.gene.edges | ProKN LINCS Negative Regulation Edges | DDKG_LINCS.Compound.NEGATIVELY_REGULATES.Gene.edges.csv (27.0 MB) | GraphProduct | csv | had primary source | LINCS compound negatively regulates g... |
| prokn.lincs.compound.positively_regulates.gene.edges | ProKN LINCS Positive Regulation Edges | DDKG_LINCS.Compound.POSITIVELY_REGULATES.Gene.edges.csv (26.9 MB) | GraphProduct | csv | had primary source | LINCS compound positively regulates g... |
| prokn.lincs_p100.perturbagen.is_used_in.experiment.edges | ProKN LINCS P100 Perturbagen Edges | LINCS_P100.Perturbagen.IS_USED_IN.Experiment.edges.csv (529.1 KB) | GraphProduct | csv | had primary source | LINCS P100 perturbagen experiment edges |
| prokn.lincs_p100.experiment.perturbation_effect.ptmsite.edges | ProKN LINCS P100 Perturbation Effect Edges | LINCS_P100.Experiment.PERTURBATION_EFFECT.PTMSite.edges.csv (50.1 MB) | GraphProduct | csv | had primary source | LINCS P100 experiment perturbation ef... |
| prokn.lincs_p100.ptmsite.is_site.site.edges | ProKN LINCS P100 PTM Site Mapping Edges | LINCS_P100.PTMSite.IS_SITE.Site.edges.csv (980 B) | GraphProduct | csv | had primary source | LINCS P100 PTM site is site of site e... |
The Library of Integrated Network-based Cellular Signatures (LINCS) is an NIH Common Fund program that catalogs how human cells globally respond to chemical, genetic, and disease perturbations. By assembling an integrated picture of the range of responses of human cells exposed to many perturbations, the LINCS program aims to better understand human disease and to advance the development of new therapies.
LINCS contains data on cellular responses to thousands of perturbagens (including drugs, genetic perturbations, tissue micro-environments, antibodies, and disease-causing mutations) across multiple cell types. These responses are measured using various high-throughput technologies including:
The program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders. The data generated by LINCS is freely available to the research community through various portals and tools, with iLINCS being one of the primary access points.
LINCS data has led to important research discoveries, including new tools for enhancing drug discovery and predicting adverse health events. Although the NIH Common Fund supported the LINCS program from 2011 to 2020, the data and resources continue to be available for researchers worldwide.
Created: May 29, 2025 | Last modified: December 13, 2025