mechreponet

is a Knowledge Graph.

MechRepoNet (Mechanistic Repositioning Network) is a knowledge graph that integrates multiple biomedical data sources to support drug repositioning via mechanistic inference.

Domains

biomedical, drug discovery, pharmacology, translational

License

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Homepage

mechreponet

Repository

GitHub

Infores ID

Unknown

FAIRsharing ID

Unknown

Product Summary

Products

From this Resource
ID Name URL Category Format Description
mechreponet.kg MechRepoNet Knowledge Graph publication ❔ The MechRepoNet knowledge graph in it...
mechreponet.code MechRepoNet Code MechRepoNet ❔ Python code for building and analyzin...
From other Resources
ID Name URL Category Format Description
mind.train ⚠ MIND Training Data train.txt GraphProduct tsv Training data for the MIND knowledge ...
mind.test ⚠ MIND Test Data test.txt GraphProduct tsv Test data for the MIND knowledge grap...
mind.valid ⚠ MIND Validation Data valid.txt GraphProduct tsv Validation data for the MIND knowledg...
mind.entities MIND Entities Dictionary entities.dict (5.4 MB) Product tsv Dictionary of entities in the MIND kn...
mind.relations MIND Relations Dictionary relations.dict (1.6 KB) Product tsv Dictionary of relations in the MIND k...

Details

MechRepoNet

MechRepoNet (Mechanistic Repositioning Network) is a knowledge graph created for the purpose of drug repositioning via mechanistic inference. It integrates multiple biomedical data sources to provide a comprehensive network of compounds, diseases, genes, pathways, and other biological entities.

Description

MechRepoNet was developed by researchers at the Su Lab to enable mechanism-based drug repositioning. The knowledge graph integrates data from various sources including:

  • Comparative Toxicogenomics Database (CTD)
  • Disease Ontology (DOID)
  • Gene Ontology (GO)
  • Chemical Entities of Biological Interest (ChEBI)
  • Reactome
  • InterPro
  • Human Phenotype Ontology (HPO)
  • Cell Ontology (CL)
  • UBERON
  • NCBI Taxonomy

The graph contains relationships between compounds, genes, diseases, pathways, GO terms, and other biological entities, allowing for mechanistic inference for drug repositioning.

References

The MechRepoNet knowledge graph is fully described in:

Mayers, M., Tu, R. (2022). MechRepoNet, a network-based tool for mechanism-based repositioning of small molecules. Bioinformatics, 38(15), 3746-3748. https://doi.org/10.1093/bioinformatics/btac431

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Created: April 12, 2022 | Last modified: July 17, 2025