is a Data Source.
The Molecular Transducers of Physical Activity Consortium (MoTrPAC) Data Hub is a national research initiative that generates a comprehensive molecular map of the effects of exercise and physical activity training. The data repository provides multi-omics datasets documenting molecular changes from exercise across multiple tissues, including transcriptomics, proteomics, metabolomics, and epigenomics data. The complete young adult rat endurance training dataset is publicly available, featuring quantitative results and analyses from 20 tissues across 29 assays and 5 time points, studying male and female animals. The data hub provides both browsable study data and pre-bundled datasets organized by tissue type and omics platform, all released under CC BY 4.0 license. The resource includes phenotypic data, sample-level metadata, quality control metrics, and quantitative results to enable comprehensive analysis of the temporal dynamics of multi-omic responses to endurance exercise training.
biological systems, health, proteomics, genomics, systems biology
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| motrpac.data-browser | MoTrPAC Data Browser | data-download | GraphicalInterface | http | Interactive data browser for explorin... |
| motrpac.phenotype | Rat Young Adult Endurance Training - Phenotype Data | data-download | Product | csv | Phenotypic data from young adult rats... |
| motrpac.epigenomics | Rat Young Adult Endurance Training - Epigenomics Data | data-download | Product | csv | Epigenomics data including ATAC-seq a... |
| motrpac.transcriptomics | Rat Young Adult Endurance Training - Transcriptomics Data | data-download | Product | csv | RNA-seq analyses, sample-level metada... |
| motrpac.proteomics-untargeted | Rat Young Adult Endurance Training - Proteomics (Untargeted) | data-download | Product | csv | Untargeted proteomics data including ... |
| motrpac.metabolomics-untargeted | Rat Young Adult Endurance Training - Metabolomics (Untargeted) | data-download | Product | csv | Untargeted metabolomics analyses, sam... |
| motrpac.metabolomics-targeted | Rat Young Adult Endurance Training - Metabolomics (Targeted) | data-download | Product | csv | Targeted metabolomics analyses, sampl... |
| motrpac.proteomics-targeted | Rat Young Adult Endurance Training - Proteomics (Targeted/Immunoassay) | data-download | Product | csv | Targeted proteomics immunoassay data ... |
| motrpac.video-tutorials | MoTrPAC Data Hub Video Tutorials | motrpac-data.org | DocumentationProduct | http | Video tutorials demonstrating how to ... |
| motrpac.data-hub | MoTrPAC Data Hub Portal | motrpac-data.org | GraphicalInterface | http | Main portal for the MoTrPAC Data Hub ... |
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| ubkg.neo4j | UBKG Neo4j Docker Distribution | ubkg-downloads.xconsortia.org | GraphProduct | ❔ | Turnkey neo4j distributions that depl... |
| ubkg.csv | UBKG Ontology CSV Files | ubkg-downloads.xconsortia.org | GraphProduct | csv | Ontology CSV files that can be import... |
MoTrPAC BioInformatics Center at Stanford University
The Molecular Transducers of Physical Activity Consortium (MoTrPAC) Data Hub is a comprehensive data repository and resource center for a national research initiative aimed at generating a molecular map of the effects of exercise and physical activity training. The consortium brings together researchers to study how physical activity influences molecular changes across multiple tissues and biological systems.
MoTrPAC’s primary objective is to map the dynamic responses to exercise at the molecular level. The consortium generates multi-omics datasets that document comprehensive molecular changes resulting from exercise training, enabling researchers to understand the mechanisms by which physical activity promotes health and prevents disease.
The complete young adult rat endurance training dataset is publicly available, representing a landmark study published in Nature (2024). This comprehensive dataset includes:
Study Design:
Available Data Types:
Pre-bundled datasets are available for individual tissues, including:
Each tissue-specific dataset includes analyses, sample-level metadata, quality control metrics, and quantitative results across all relevant omics platforms.
All datasets include:
Data are provided in standardized formats:
The MoTrPAC Data Hub offers flexible data access:
The temporal dynamics study revealed:
The MoTrPAC Data Hub is designed and maintained by the MoTrPAC BioInformatics Center at Stanford University. The infrastructure includes:
All MoTrPAC data are released under the Creative Commons Attribution 4.0 International (CC BY 4.0) license, promoting open science and data reuse. Users are required to:
The foundational MoTrPAC publication describing the consortium’s goals, structure, and approach:
The comprehensive analysis of the young adult rat endurance training study:
MoTrPAC maintains active engagement with the research community through:
While the young adult rat endurance training dataset is currently publicly available, MoTrPAC has additional ongoing studies across:
Data from these studies will be released as they become available, expanding the molecular map of exercise responses.
MoTrPAC is funded by the NIH Common Fund, supporting this large-scale collaborative effort to understand the molecular mechanisms underlying the health benefits of physical activity.
Created: October 29, 2025 | Last modified: October 29, 2025