is a Data Source.
MR-Base is a platform that integrates a large database of harmonized GWAS summary association datasets with analytical tools (web apps and R packages) to support systematic two-sample Mendelian randomization (2SMR) and phenome-wide causal inference across the human phenome.
biomedical, genomics, general
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| mrbase.home ⚠ | MR-Base Website | www.mrbase.org | GraphicalInterface | http | Web home and informational landing pa... |
| mrbase.webapp ⚠ | MR-Base Web Application | app.mrbase.org | GraphicalInterface | http | Interactive Shiny-based web applicati... |
| mrbase.phewas | MR-Base PheWAS Application | phewas | GraphicalInterface | http | Phenome-wide association study (PheWA... |
| mrbase.api ⚠ | MR-Base REST API | api.mrbase.org | ProgrammingInterface | ❔ | RESTful API providing programmatic ac... |
| mrbase.twosamplemr | TwoSampleMR R Package | TwoSampleMR | ProgrammingInterface | ❔ | TwoSampleMR R package supporting data... |
| mrbase.mrinstruments | MRInstruments R Package | MRInstruments | ProgrammingInterface | ❔ | MRInstruments R package containing cu... |
| mrbase.twosamplemr.docs | TwoSampleMR Documentation | TwoSampleMR | DocumentationProduct | http | TwoSampleMR package documentation wit... |
| mrbase.paper.reproducibility | MR-Base Methods Paper Reproducibility Code | mr-base-methods-paper | DocumentationProduct | ❔ | Methods paper analysis reproduction c... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| opengwas.portal | IEU OpenGWAS Portal | opengwas.io | GraphicalInterface | http | was informed by | IEU OpenGWAS browser for exploring th... |
| opengwas.api | IEU OpenGWAS API | api | ProgrammingInterface | http | was informed by | REST API for programmatic access to I... |
| epigraphdb.graph | EpiGraphDB Graph Database | graph-database | GraphProduct | neo4j | had primary source | Integrated graph knowledge base combi... |
| prsatlas.dryad | PRS Atlas Dryad Archive | dryad.h18c66b | Product | http | was derived from | Dryad archive for PRS Atlas results, ... |
| prsatlas.results_5e05 ⚠ | PRS Atlas Results P less than 5e-05 | 83029 | Product | txt | was derived from | PRS Atlas results using the P less th... |
| prsatlas.results_5e08 ⚠ | PRS Atlas Results P less than 5e-08 | 83030 | Product | txt | was derived from | PRS Atlas results using the P less th... |
| opengwas.datasets | IEU OpenGWAS Dataset Catalog | opengwas.io | Product | mixed | was informed by | OpenGWAS GWAS summary dataset catalog... |
MR-Base integrates thousands of harmonized genome-wide association study (GWAS) summary datasets with analytical tooling for systematic two-sample Mendelian randomization (2SMR). The platform supports reproducible causal inference by coupling data extraction, instrument selection, harmonization, statistical analysis, sensitivity diagnostics, and reporting across a large and evolving catalog of phenotypes.
Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, Tan VY, Yarmolinsky J, Shihab HA, Timpson NJ, Evans DM, Relton C, Martin RM, Davey Smith G, Gaunt TR, Haycock PC. The MR-Base platform supports systematic causal inference across the human phenome. eLife. 2018;7:e34408. doi:10.7554/eLife.34408
The platform paper is distributed under CC-BY 4.0. Access to certain GWAS datasets may require authentication or have embargo policies; API access governs permissions using OAuth. Users should review linked dataset source terms when reusing summary statistics.
For scientific or data queries, contact corresponding authors (jie.zheng@bristol.ac.uk, tom.gaunt@bristol.ac.uk, philip.haycock@bristol.ac.uk) or Gibran Hemani (g.hemani@bristol.ac.uk). General platform information: https://www.mrbase.org/.
Created: September 03, 2025 | Last modified: June 02, 2026