is a Data Source.
ORegAnno (the Open Regulatory Annotation database) is a community-driven, literature-curated resource of regulatory regions, transcription factor binding sites, regulatory polymorphisms, and regulatory interactions across multiple species. It served as an upstream primary source for regulatory annotation resources such as DoRothEA. The original standalone interactive site (oreganno.org) is no longer operational and now redirects to the UCSC Genome Browser; the curated ORegAnno 3.0 data set lives on as a track and bulk download in the UCSC Genome Browser and is also distributed via Ensembl.
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No external IDs available
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| oreganno.ucsc | ORegAnno UCSC Track Download | oreganno.txt.gz (19.5 MB) | Product | gff | ORegAnno 3.0 regulatory annotation as... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| dorothea.graph | DoRothEA Regulon Graph | v1.0.0 | Graph | r | had primary source | Core TF–target regulon knowledge grap... |
| tflink.downloads | TFLink Downloads | download | Product | http | had primary source | Download page listing interaction tab... |
| tflink.interactions.human | TFLink Human Interactions | TFLink_Homo_sapiens_interactions_All_simpleFormat_v1.0.tsv.gz (295.1 MB) | Graph | tsv | had primary source | All TF-target gene interactions for H... |
| tflink.interactions.mouse | TFLink Mouse Interactions | TFLink_Mus_musculus_interactions_All_simpleFormat_v1.0.tsv.gz (166.9 MB) | Graph | tsv | had primary source | All TF-target gene interactions for M... |
| tflink.interactions.rat | TFLink Rat Interactions | TFLink_Rattus_norvegicus_interactions_All_simpleFormat_v1.0.tsv (12.4 MB) | Graph | tsv | had primary source | All TF-target gene interactions for R... |
| tflink.interactions.zebrafish | TFLink Zebrafish Interactions | TFLink_Danio_rerio_interactions_All_simpleFormat_v1.0.tsv (3.3 MB) | Graph | tsv | had primary source | All TF-target gene interactions for D... |
| tflink.interactions.fly | TFLink Fruit Fly Interactions | TFLink_Drosophila_melanogaster_interactions_All_simpleFormat_v1.0.tsv (53.9 MB) | Graph | tsv | had primary source | All TF-target gene interactions for D... |
| tflink.interactions.worm | TFLink Nematode Interactions | TFLink_Caenorhabditis_elegans_interactions_All_simpleFormat_v1.0.tsv (46.2 MB) | Graph | tsv | had primary source | All TF-target gene interactions for C... |
| tflink.interactions.yeast | TFLink Yeast Interactions | TFLink_Saccharomyces_cerevisiae_interactions_All_simpleFormat_v1.0.tsv (42.1 MB) | Graph | tsv | had primary source | All TF-target gene interactions for S... |
| tflink.interactions.human.mitab | TFLink Human Interactions (MITAB) | TFLink_Homo_sapiens_interactions_All_mitab_v1.0.tsv.gz (218.9 MB) | Graph | psi_mi_mitab | had primary source | All human TF-target gene interactions... |
| tflink.gmt.human | TFLink Human TF Target Gene Sets | TFLink_Homo_sapiens_interactions_All_GMT_ncbiGeneID_v1.0.gmt (36.1 MB) | Product | tsv | had primary source | Human gene sets, one per transcriptio... |
| tflink.binding-sites.human | TFLink Human Binding Sites | TFLink_Homo_sapiens_bindingSites_All_annotation_v1.0.tsv.gz (153.1 MB) | Product | tsv | had primary source | Genomic locations of human TF binding... |
| tflink.binding-sites.human.gff3 | TFLink Human Binding Sites (GFF3) | TFLink_Homo_sapiens_bindingSites_All_annotation_v1.0.gff3 (913.7 MB) | Product | gff | had primary source | Human TF binding site locations as a ... |
| tflink.binding-sites.human.fasta | TFLink Human Binding Site Sequences | TFLink_Homo_sapiens_bindingSites_All_v1.0.fasta (1.1 GB) | Product | fasta | had primary source | Nucleotide sequences of human TF bind... |
ORegAnno (the Open Regulatory Annotation database) is an open, community-curated collection of regulatory annotation. It captures regulatory regions, transcription factor binding sites, regulatory polymorphisms, and curated regulatory interactions, each linked to supporting literature evidence and target genes across multiple species.
ORegAnno is largely a legacy resource. The original standalone site at oreganno.org is no longer operational as an interactive database and now redirects to the UCSC Genome Browser. The curated ORegAnno 3.0 data persists through the UCSC Genome Browser (ORegAnno track and bulk downloads) and Ensembl, which is how the data remains accessible today.
goldenPath bulk downloadsORegAnno served as an upstream primary source for downstream regulatory resources, including DoRothEA.
Lesurf R, Cotto KC, Wang G, et al. “ORegAnno 3.0: a community-driven resource for curated regulatory annotation.” Nucleic Acids Res. 2016. doi:10.1093/nar/gkv1203
Created: June 18, 2026 | Last modified: September 23, 2026