is a Data Source.
ORegAnno (the Open Regulatory Annotation database) is a community-driven, literature-curated resource of regulatory regions, transcription factor binding sites, regulatory polymorphisms, and regulatory interactions across multiple species. It served as an upstream primary source for regulatory annotation resources such as DoRothEA. The original standalone interactive site (oreganno.org) is no longer operational and now redirects to the UCSC Genome Browser; the curated ORegAnno 3.0 data set lives on as a track and bulk download in the UCSC Genome Browser and is also distributed via Ensembl.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| oreganno.ucsc | ORegAnno UCSC Track Download | oreganno.txt.gz (19.5 MB) | DataProduct | gff | ORegAnno 3.0 regulatory annotation as... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| dorothea.graph | DoRothEA Regulon Graph | v1.0.0 | GraphProduct | ❔ | had primary source | Core TF–target regulon knowledge grap... |
ORegAnno (the Open Regulatory Annotation database) is an open, community-curated collection of regulatory annotation. It captures regulatory regions, transcription factor binding sites, regulatory polymorphisms, and curated regulatory interactions, each linked to supporting literature evidence and target genes across multiple species.
ORegAnno is largely a legacy resource. The original standalone site at oreganno.org is no longer operational as an interactive database and now redirects to the UCSC Genome Browser. The curated ORegAnno 3.0 data persists through the UCSC Genome Browser (ORegAnno track and bulk downloads) and Ensembl, which is how the data remains accessible today.
goldenPath bulk downloadsORegAnno served as an upstream primary source for downstream regulatory resources, including DoRothEA.
Lesurf R, Cotto KC, Wang G, et al. “ORegAnno 3.0: a community-driven resource for curated regulatory annotation.” Nucleic Acids Res. 2016. doi:10.1093/nar/gkv1203
Created: June 18, 2026 | Last modified: June 18, 2026