pdbe

is an Aggregator.

PDBe-KB (Protein Data Bank in Europe - Knowledge Base) is an open, collaborative consortium for integration and enrichment of 3D-structure data and functional annotations to enable basic and translational research. It provides comprehensive access to macromolecular structure data integrated with functional annotations from multiple sources.

Domains

biomedical, genomics, proteomics, anatomy and development

License

CC BY 4.0

Homepage

pdbe

Repository

GitHub

Infores ID

Unknown

FAIRsharing ID

Unknown

Product Summary

Products

From this Resource
ID Name URL Category Format Description
pdbe.kb-portal PDBe-KB Web Portal pdbe-kb GraphicalInterface http PDBe-KB web portal providing access t...
pdbe.kb-graph-database.neo4j3 PDBe-KB Graph Database for Neo4J 3.5 graphdb GraphProduct neo4j Neo4j graph database containing integ...
pdbe.kb-graph-database.neo4j4 PDBe-KB Graph Database for Neo4J 4 graphdb GraphProduct neo4j Neo4j graph database containing integ...
pdbe.kb-api PDBe-KB Graph API pdbe_doc ProgrammingInterface http RESTful API powered by the PDBe-KB gr...
pdbe.kb-ftp PDBe-KB FTP Archive pdbe-kb Product http FTP archive providing bulk download a...
pdbe.download-service PDBe Download Service docs Product mixed Downloadable coordinate files, experi...
pdbe.sifts SIFTS Residue-level Mapping docs Product xml SIFTS (Structure Integration with Fun...
pdbe.kb-manual PDBe-KB User Manual pdbe-kb-manual DocumentationProduct http User guides and documentation for PDB...
pdbe.kb-schema PDBe Graph Database Schema Explorer schema DocumentationProduct http Interactive schema explorer for the P...
From other Resources
ID Name URL Category Format Description
rnacentral.portal RNAcentral Portal rnacentral.org GraphicalInterface http Web portal for searching and browsing...
rnacentral.api RNAcentral REST API api ProgrammingInterface http REST API for programmatic access to R...
rnacentral.ftp RNAcentral FTP Archive RNAcentral Product http FTP archive with current and archived...
rnacentral.public-db RNAcentral Public Postgres Database public-database DataModelProduct postgres Public PostgreSQL database for direct...
genecards.protein.structures GeneCards Protein Structure Data www.genecards.org Product http Protein structure data from PDB Europ...
goa.pdb PDB GOA Annotations PDB Product txt GO annotations for PDB entries

Details

PDBe Knowledge Base

PDBe-KB (Protein Data Bank in Europe - Knowledge Base) is an open, collaborative consortium for integration and enrichment of 3D-structure data and functional annotations to enable basic and translational research.

Mission

  • Implement a comprehensive, FAIR infrastructure for macromolecular structures and their annotations
  • Enrich macromolecular structure data with structural and functional annotations to establish their biological context
  • Develop innovative tools for data access and visualisation

Key Features

  • Experimental and Predicted Protein Structures: Integration of experimental structures from PDB with predicted models
  • Superposition of Protein Chains and Ligands: Visualization and analysis of structural superpositions
  • Graph Database: Neo4j-based graph database with over 150 million residues linked to functional annotations
  • Unified Access: Integration with UniProt through SIFTS residue-level mapping

Graph Database

The PDBe-KB graph database is implemented in Neo4J and represents each PDB entry as a tree structure:

  • Root: PDB entry
  • Connected to: chains and entities
  • Further connected to: residues (>150 million)
  • Each residue is linked to:
    • Available annotations (e.g., catalytic sites, interaction interfaces)
    • Corresponding UniProt residues

This graph structure enables straightforward transfer of annotations between PDB entries mapping to the same UniProt accession and highly identical UniProt accessions.

Access Methods

  • Web Portal: Interactive browsing and visualization
  • Graph API: RESTful API for programmatic access
  • FTP: Bulk download of data files
  • Direct Database Access: Query the Neo4j graph database
  • Download Service: Structured download of specific data types

Citation

If you use this resource, please cite:

PDBe-KB consortium. PDBe-KB: collaboratively defining the biological context of structural data. Nucleic Acids Research, Database Issue (2022). https://doi.org/10.1093/nar/gkab988

License

All data is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC BY 4.0) license.

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Created: September 09, 2025 | Last modified: October 08, 2025