is an Aggregator.
PhosphoSitePlus is a comprehensive resource for experimentally validated post-translational modifications (PTMs) with emphasis on phosphorylation, ubiquitination, acetylation, methylation and more. It aggregates curated site-specific modification data, kinase–substrate relationships, protein domains, mutation impact annotations, sequence motifs, and pathway/interaction context to support signaling, proteomics, and systems biology research.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| phosphositeplus.portal | PhosphoSitePlus Portal | www.phosphosite.org | Graphical Interface | http | Web portal for browsing PTM sites, ki... |
| phosphositeplus.downloads | PhosphoSitePlus Downloads | staticDownloads | Product | http | Bulk data downloads (PTM site tables,... |
| phosphositeplus.about | PhosphoSitePlus About & Methods | staticAboutPhosphosite | Documentation | http | Methodology and curation overview inc... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| clinicalkg.graph | CKG Graph Dump | 1 | Graph | mixed | had primary source | Neo4j database dump of the Clinical K... |
| cancer-genome-interpreter.clinicalkg.graph | CKG Graph Dump | 1 | Graph | mixed | had primary source | Neo4j database dump of the Clinical K... |
| kinace.portal | KiNet Web Portal | kinet.kinametrix.com | Graphical Interface | http | was derived from | Interactive Shiny web interface for e... |
| unibiomap.links | UniBioMap Graph Links | unibiomap.links.csv (1.3 GB) | Graph | csv | had primary source | Core UniBioMap graph edges file. |
| unibiomap.auxs | UniBioMap Graph Auxiliaries | unibiomap.auxs.tsv (563.9 MB) | Graph | tsv | had primary source | Auxiliary UniBioMap graph annotations... |
| unibiomap.pred | UniBioMap Predicted Graph | unibiomap.pred.csv (2.3 GB) | Graph | csv | had primary source | Predicted UniBioMap graph edges with ... |
| unibiomap.pred.full | UniBioMap Predicted Graph (Full) | unibiomap.pred.full.csv (5.9 GB) | Graph | csv | had primary source | Full unfiltered UniBioMap predicted g... |
| ckg.graph | CKG Graph Database Dump | 1 | Graph | neo4j | had primary source | Graph database dump and additional re... |
| epsd.download | EPSD Data Download | Download.php | Product | http | was derived from | Download page for complete phosphoryl... |
| iptmnet.ptm | iPTMnet PTM Table | ptm.txt (42.1 MB) | Graph | tsv | was derived from | Current iPTMnet PTM record table with... |
| kinace.interactions | KiNet Full Interaction Dataset | ksi_source_full_dataset.csv (4.9 MB) | Graph | csv | was derived from | CSV download of the full KiNet human ... |
| ptmd.total_pda | PTMD Total PTM-Disease Associations | Total.zip (4.5 MB) | Product | tsv | was derived from | Complete PTMD 2.0 PTM-disease associa... |
| ptmd.phosphorylation_pda | PTMD Phosphorylation PTM-Disease Associations | Phosphorylation.zip (2.8 MB) | Product | tsv | was derived from | PTMD 2.0 PTM-disease association subs... |
| activedriverdb.downloads | ActiveDriverDB Downloads | download | Product | tsv | was derived from | Bulk downloadable ActiveDriverDB data... |
| harmonizome.downloads | Harmonizome Downloads | download | Product | mixed | was derived from | Harmonizome 3.0 processed dataset dow... |
| harmonizome.kg-neo4j | Harmonizome Knowledge Graph Neo4j Database | harmonizome-kg.maayanlab.cloud | Graph | neo4j | was derived from | Neo4j knowledge graph serialization o... |
| pathwaycommons.downloads | Pathway Commons Data Downloads | v14 | Product | mixed | was derived from | Download directory for Pathway Common... |
| pathwaycommons.biopax | Integrated BioPAX Model | pc-biopax.owl.gz (1.6 GB) | Product | biopax | was derived from | PC v14 integrated BioPAX Level 3 unif... |
| pathwaycommons.sif | SIF Network Format | pc-hgnc.sif.gz (9.4 MB) | Product | sif | was derived from | PC v14 Simple Interaction Format netw... |
| pathwaycommons.gmt | GMT Gene Set Format | pc-hgnc.gmt.gz (256.4 KB) | Product | tsv | was derived from | PC v14 Gene Matrix Transposed gene se... |
| pathwaycommons.txt | Extended SIF TXT Format | pc-hgnc.txt.gz (110.3 MB) | Product | txt | was derived from | PC v14 tab-delimited extended SIF nod... |
PhosphoSitePlus aggregates high-quality experimentally validated post-translational modification (PTM) information, including phosphorylation, ubiquitination, acetylation, methylation, SUMOylation and others. Each modification site is annotated with residue position, surrounding sequence context, upstream enzymes (where known), literature references, and functional notes.
Please cite the latest PhosphoSitePlus update and foundational 2011 description paper when using the resource.
Created: August 12, 2025 | Last modified: September 23, 2026