probe-miner

is a Data Source.

Probe Miner is a public resource for the objective, quantitative, and data-driven assessment of chemical probes for protein targets, developed at the Institute of Cancer Research. It integrates large-scale, publicly available medicinal chemistry and bioactivity data to score small molecules against six objective criteria, enabling researchers to evaluate the suitability of compounds as chemical probes for a given protein target. The resource helps reduce the misuse of poor-quality chemical probes in target validation and chemical biology by surfacing potency, selectivity, and cell-based activity evidence in a transparent, reproducible way.

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Domains

drug discovery, chemistry and biochemistry, pharmacology

License

Not specified

Homepage

probe-miner

Repository

Unknown

Infores ID

infores:probe-miner

FAIRsharing ID

Unknown

Product Summary

Products

From this Resource
ID Name URL Category Format Description
probe-miner.website Probe Miner Web Resource probeminer.icr.ac.uk GraphicalInterface http Public web interface for searching an...
From other Resources
ID Name URL Category Format Relation Description
molecular-data-kp.graph.nodes Nodes for Molecular Data KP nodes.tsv (3.4 GB) GraphProduct kgx had primary source KGX nodes for Molecular Data KP
molecular-data-kp.graph.edges Edges for Molecular Data KP edges.tsv (18.8 GB) GraphProduct kgx had primary source KGX edges for Molecular Data KP

Details

Probe Miner

Overview

Probe Miner is a public, data-driven resource developed at the Institute of Cancer Research that provides objective, quantitative assessments of chemical probes for protein targets. By mining large-scale public medicinal chemistry and bioactivity data, it scores small molecules against a set of objective criteria so that researchers can judge whether a compound is a suitable chemical probe for a given target.

Scope & Content

  • Objective, quantitative scoring of compounds across six chemical probe quality criteria
  • Coverage of small-molecule potency, selectivity, and cell-based activity evidence
  • Assessment of chemical probes across a broad space of human protein targets
  • Transparent, reproducible evaluations derived from public bioactivity data

Use Cases

  • Selecting high-quality chemical probes for target validation
  • Avoiding poor-quality or non-selective probes in chemical biology experiments
  • Comparing candidate compounds for a protein target of interest
  • Providing upstream probe-assessment data to integrative knowledge graphs (e.g., MolePro / molecular-data-kp)

Access

The Probe Miner web resource is publicly available and can be searched and browsed by protein target or compound.

Citation & Attribution

When using Probe Miner, cite Antolin et al. (2018), “Objective, Quantitative, Data-Driven Assessment of Chemical Probes,” Cell Chemical Biology.

Contact

General inquiries can be directed to the Institute of Cancer Research via its website.

Is this information incorrect or incomplete? Request an update.

Created: June 18, 2026 | Last modified: June 27, 2026