prokn

is a Knowledge Graph.

It is part of the OKN collection.

The Protein Knowledge Network (ProKN) integrates protein-centric data with the genomic-centric datasets of the Common Fund Data Ecosystem (CFDE), spanning heterogeneous biological data types across multiple domains to foster CFDE re-use and collaboration through enhanced connectivity and data integration, enabling new capabilities for functional genomics and systems-level understanding of disease mechanisms.

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Domains

proteomics, genomics, systems biology

License

GSEA/MSigDB License Terms (inferred)

Homepage

prokn

Repository

Unknown

Infores ID

Unknown

FAIRsharing ID

Unknown

Product Summary

Contacts

Chuming Chen

Github: chenchuming

Products

From this Resource
ID Name URL Category Format Description
prokn.glygen.aminoacid.nodes ProKN GlyGen AminoAcid Nodes DDKG_PROTEOFORM.AminoAcid.nodes.csv (853 B) Graph csv GlyGen amino acid nodes used in ProKN
prokn.gtexexp.anatomy.nodes ProKN GTEx Anatomy Nodes DDKG_GTEXEXP.Anatomy.nodes.csv (6.8 KB) Graph csv GTEx expression anatomy nodes (GTEXEX...
prokn.hmaz.anatomy.nodes ProKN HuBMAP Azimuth Anatomy Nodes DDKG_HMAZ.Anatomy.nodes.csv (12.4 KB) Graph csv HuBMAP Azimuth anatomy nodes used in ...
prokn.imex.complex.nodes ProKN IMEx Complex Nodes IMEx.Complex.nodes.csv (1.3 MB) Graph csv IMEx complex nodes used in ProKN
prokn.idgp.compound.nodes ProKN TCRD Compound-Protein Compound Nodes DDKG_IDGP.Compound.nodes.csv (80.1 MB) Graph csv IDG/TCRD compound-protein nodes used ...
prokn.idgd.compound.nodes ProKN TCRD Compound-Disease Compound Nodes DDKG_IDGD.Compound.nodes.csv (103.3 KB) Graph csv IDG/TCRD compound-disease nodes used ...
prokn.hmaz.anatomy.has_marker_gene_in_heart.gene.edges ProKN HuBMAP Azimuth Heart Marker Edges DDKG_HMAZ.Anatomy.HAS_MARKER_GENE_IN_HEART.Gene.edges.csv (47.2 KB) Graph csv HuBMAP Azimuth anatomy to heart marke...
prokn.hmaz.anatomy.has_marker_gene_in_kidney.gene.edges ProKN HuBMAP Azimuth Kidney Marker Edges DDKG_HMAZ.Anatomy.HAS_MARKER_GENE_IN_KIDNEY.Gene.edges.csv (124.0 KB) Graph csv HuBMAP Azimuth anatomy to kidney mark...
prokn.hmaz.anatomy.has_marker_gene_in_liver.gene.edges ProKN HuBMAP Azimuth Liver Marker Edges DDKG_HMAZ.Anatomy.HAS_MARKER_GENE_IN_LIVER.Gene.edges.csv (55.4 KB) Graph csv HuBMAP Azimuth anatomy to liver marke...
prokn.idgp.compound.bioactivity.protein.edges ProKN TCRD Compound-Protein Bioactivity Edges DDKG_IDGP.Compound.BIOACTIVITY.Protein.edges.csv (122.2 MB) Graph csv TCRD compound bioactivity to protein ...
prokn.lincs.compound.in_similarity_relationship_with.compound.edges ProKN LINCS Compound Similarity Edges DDKG_LINCS.Compound.IN_SIMILARITY_RELATIONSHIP_WITH.Compound.edges.csv (5.9 MB) Graph csv LINCS compound similarity edges
prokn.idgd.compound.indication.diseaseorphenotype.edges ProKN TCRD Compound-Disease Indication Edges DDKG_IDGD.Compound.INDICATION.DiseaseOrPhenotype.edges.csv (1.6 MB) Graph csv TCRD compound indication edges to dis...
prokn.lincs.compound.negatively_regulates.gene.edges ProKN LINCS Negative Regulation Edges DDKG_LINCS.Compound.NEGATIVELY_REGULATES.Gene.edges.csv (27.0 MB) Graph csv LINCS compound negatively regulates g...
prokn.lincs.compound.positively_regulates.gene.edges ProKN LINCS Positive Regulation Edges DDKG_LINCS.Compound.POSITIVELY_REGULATES.Gene.edges.csv (26.9 MB) Graph csv LINCS compound positively regulates g...
prokn.pir.compound.skos_exact_match.compound.edges ProKN PIR Compound Exact Match Edges PIR.Compound.SKOS_EXACT_MATCH.Compound.edges.csv (95.5 MB) Graph csv PIR compound exact match edges
prokn.pir.gene.skos_exact_match.impchumangene.edges ProKN PIR Gene Exact Match Edges PIR.Gene.SKOS_EXACT_MATCH.ImpcHumanGene.edges.csv (4.6 MB) Graph csv PIR gene exact match to IMPC human ge...
prokn.interpro.domain.is_a.domain.edges ProKN InterPro Domain Hierarchy Edges InterPro.Domain.IS_A.Domain.edges.csv (167.0 KB) Graph csv InterPro domain is_a domain edges
prokn.hgnchpo.gene.associated_with.diseaseorphenotype.edges ProKN HPO Gene-to-Phenotype Association Edges DDKG_HGNCHPO.Gene.ASSOCIATED_WITH.DiseaseOrPhenotype.edges.csv (148.6 MB) Graph csv HPO gene-to-phenotype association edges
prokn.gtexexp.gene.expressed_in.anatomy.edges ProKN GTEx Gene Expression Edges DDKG_GTEXEXP.Gene.EXPRESSED_IN.Anatomy.edges.csv (325.3 MB) Graph csv GTEx gene expressed in anatomy edges
prokn.clinvar.gene.associated_with.diseaseorphenotype.edges ProKN ClinVar Association Edges DDKG_CLINVAR.Gene.GENE_ASSOCIATED_WITH_DISEASE_OR_PHENOTYPE.DiseaseOrPhenotype.edges.csv (16.1 MB) Graph csv ClinVar gene associated with disease/...
prokn.hgncuniprot.gene.is_protein.protein.edges ProKN HGNC UniProt Gene-Protein Edges DDKG_HGNCUNIPROT.Gene.IS_PROTEIN.Protein.edges.csv (1.7 MB) Graph csv HGNC to UniProt gene is_protein edges
prokn.pir.gene.skos_exact_match.impc_gene.edges ProKN PIR Gene Exact Match Edges PIR.Gene.SKOS_EXACT_MATCH.ImpcHumanGene.edges.csv (4.6 MB) Graph csv PIR gene exact match to IMPC human ge...
prokn.glygen.glycoprotein.glycosylated_at.glycosylationsite.edges ProKN GlyGen Glycosylated Site Edges DDKG_PROTEOFORM.Glycoprotein.GLYCOSYLATED_AT.GlycosylationSite.edges.csv (13.4 MB) Graph csv GlyGen glycoprotein glycosylated site...
prokn.glygen.glycoprotein.has_evidence.glycoproteinevidence.edges ProKN GlyGen Evidence Edges DDKG_PROTEOFORM.Glycoprotein.HAS_EVIDENCE.GlycoproteinEvidence.edges.csv (32.3 MB) Graph csv GlyGen glycoprotein evidence edges
prokn.glygen.glycoprotein.has_pro_entry.gpid2pro.edges ProKN GlyGen PRO Entry Edges DDKG_PROTEOFORM.Glycoprotein.HAS_PRO_ENTRY.GPID2PRO.edges.csv (14.8 MB) Graph csv GlyGen glycoprotein PRO entry edges
prokn.glygen.glycoprotein.sequence.isoform.edges ProKN GlyGen Isoform Sequence Edges DDKG_PROTEOFORM.Glycoprotein.SEQUENCE.Isoform.edges.csv (6.8 MB) Graph csv GlyGen glycoprotein isoform sequence ...
prokn.glygen.glycoprotein.sequence.protein.edges ProKN GlyGen Protein Sequence Edges DDKG_PROTEOFORM.Glycoprotein.SEQUENCE.Protein.edges.csv (7.4 MB) Graph csv GlyGen glycoprotein protein sequence ...
prokn.glygen.glycoproteinevidence.citation.glycoproteincitation.edges ProKN GlyGen Evidence Citation Edges DDKG_PROTEOFORM.GlycoproteinEvidence.CITATION.GlycoproteinCitation.edges.csv (558.3 KB) Graph csv GlyGen glycoprotein evidence citation...
prokn.glygen.glycosylation.has_enzyme_protein.protein.edges ProKN GlyGen Enzyme Protein Edges DDKG_GLYCANS.Glycosylation.HAS_ENZYME_PROTEIN.Protein.edges.csv (23.2 KB) Graph csv GlyGen glycosylation enzyme protein e...
prokn.glygen.glycosylationsite.has_saccharide.glytoucan.edges ProKN GlyGen Saccharide Edges DDKG_PROTEOFORM.GlycosylationSite.HAS_SACCHARIDE.Glytoucan.edges.csv (10.8 MB) Graph csv GlyGen glycosylation site saccharide ...
prokn.glygen.glycosylationsite.location.glygenlocation.edges ProKN GlyGen Site Location Edges DDKG_PROTEOFORM.GlycosylationSite.LOCATION.GlyGenLocation.edges.csv (12.2 MB) Graph csv GlyGen glycosylation site location edges
prokn.glygen.glycosyltransferasereaction.has_enzyme_protein_gr.protein.edges ProKN GlyGen Reaction Enzyme Edges DDKG_GLYCANS.GlycosyltransferaseReaction.HAS_ENZYME_PROTEIN_GR.Protein.edges.csv (24.4 KB) Graph csv GlyGen glycosyltransferase reaction e...
prokn.glygen.glygenlocation.has_amino_acid.aminoacid.edges ProKN GlyGen Location Amino Acid Edges DDKG_PROTEOFORM.GlyGenLocation.HAS_AMINO_ACID.AminoAcid.edges.csv (11.9 MB) Graph csv GlyGen location amino acid edges
prokn.glygen.glygenresidue.attached_by.glycosylation.edges ProKN GlyGen Residue Attachment Edges DDKG_GLYCANS.GlyGenResidue.ATTACHED_BY.Glycosylation.edges.csv (85.9 KB) Graph csv GlyGen residue attached by glycosylat...
prokn.glygen.glygenresidue.has_parent.glygenresidue.edges ProKN GlyGen Residue Parent Edges DDKG_GLYCANS.GlyGenResidue.HAS_PARENT.GlyGenResidue.edges.csv (18.2 KB) Graph csv GlyGen residue parent edges
prokn.glygen.glytoucan.has_canonical_residue.glygenresidue.edges ProKN GlyGen Canonical Residue Edges DDKG_GLYCANS.Glytoucan.HAS_CANONICAL_RESIDUE.GlyGenResidue.edges.csv (20.7 MB) Graph csv GlyGen glytoucan canonical residue edges
prokn.glygen.glytoucan.has_glycosequence.gyglycosequence.edges ProKN GlyGen Glycosequence Edges DDKG_GLYCANS.Glytoucan.HAS_GLYCOSEQUENCE.GlyGenGlycosequence.edges.csv (30.3 MB) Graph csv GlyGen glytoucan glyco-sequence edges
prokn.glygen.glytoucan.has_motif.glycanmotif.edges ProKN GlyGen Motif Edges DDKG_GLYCANS.Glytoucan.HAS_MOTIF.GlycanMotif.edges.csv (4.2 MB) Graph csv GlyGen glytoucan motif edges
prokn.glygen.glytoucan.is_from_source.glygensrc.edges ProKN GlyGen Source Edges DDKG_GLYCANS.Glytoucan.IS_FROM_SOURCE.GlyGenSrc.edges.csv (7.4 MB) Graph csv GlyGen glytoucan source edges
prokn.glygen.glytoucan.synthesized_by.glycosyltransferasereaction.edges ProKN GlyGen Synthesized By Edges DDKG_GLYCANS.Glytoucan.SYNTHESIZED_BY.GlycosyltransferaseReaction.edges.csv (52.2 MB) Graph csv GlyGen glytoucan synthesized by react...
prokn.go.goterm.is_a.goterm.edges ProKN GO Term Hierarchy Edges GO.GOTerm.IS_A.GOTerm.edges.csv (11.4 MB) Graph csv GO term hierarchy edges
prokn.gtexexp.gtexexp.expressed_in.anatomy.edges ProKN GTExEXP Anatomy Expression Edges DDKG_GTEXEXP.GTExEXP.EXPRESSED_IN.Anatomy.edges.csv (387.6 MB) Graph csv GTEx expression to anatomy edges (GTE...
prokn.gtexexp.gtexexp.expressed_in.gene.edges ProKN GTExEXP Gene Expression Edges DDKG_GTEXEXP.GTExEXP.EXPRESSED_IN.Gene.edges.csv (368.8 MB) Graph csv GTEx expression to gene edges (GTExEX...
prokn.gtexexp.gtexexp.has_expression.expbins.edges ProKN GTExEXP Expression Bin Edges DDKG_GTEXEXP.GTExEXP.HAS_EXPRESSION.EXPBINS.edges.csv (394.4 MB) Graph csv GTEx expression to expression bins edges
prokn.impc.impcallele.impc_ensembl_id.impcmousegene.edges ProKN IMPC Allele to Mouse Gene Edges IMPC.ImpcAllele.IMPC_ENSEMBL_ID.ImpcMouseGene.edges.csv (29.5 MB) Graph csv IMPC allele to mouse gene edges
prokn.impc.impchumangene.interacts_with.impchumangene.edges ProKN IMPC Human-Human Interaction Edges IMPC.ImpcHumanGene.BIOLINK_INTERACTS_WITH.ImpcHumanGene.edges.csv (1.2 GB) Graph csv IMPC human gene interacts with human ...
prokn.impc.impchumangene.interacts_with.impcmousegene.edges ProKN IMPC Human-Mouse Interaction Edges IMPC.ImpcHumanGene.BIOLINK_INTERACTS_WITH.ImpcMouseGene.edges.csv (7.9 MB) Graph csv IMPC human gene interacts with mouse ...
prokn.impc.impchumangene.orthologous_to.impcmousegene.edges ProKN IMPC Ortholog Edges IMPC.ImpcHumanGene.BIOLINK_ORTHOLOGOUS_TO.ImpcMouseGene.edges.csv (16.0 MB) Graph csv IMPC human gene orthologous to mouse ...
prokn.pir.impchumangene.orthologous_to.protein.edges ProKN PIR Human Gene to Protein Ortholog Edges PIR.ImpcHumanGene.BIOLINK_ORTHOLOGOUS_TO.Protein.edges.csv (17.2 MB) Graph csv PIR IMPC human gene orthologous to pr...
prokn.pir.impcmousegene.has_gene_product.protein.edges ProKN PIR Mouse Gene Product Edges PIR.ImpcMouseGene.BIOLINK_HAS_GENE_PRODUCT.Protein.edges.csv (18.6 MB) Graph csv PIR IMPC mouse gene has gene product ...
prokn.impc.impcmousegene.interacts_with.impchumangene.edges ProKN IMPC Mouse-Human Interaction Edges IMPC.ImpcMouseGene.BIOLINK_INTERACTS_WITH.ImpcHumanGene.edges.csv (25.2 MB) Graph csv IMPC mouse gene interacts with human ...
prokn.impc.impcmousegene.interacts_with.impcmousegene.edges ProKN IMPC Mouse-Mouse Interaction Edges IMPC.ImpcMouseGene.BIOLINK_INTERACTS_WITH.ImpcMouseGene.edges.csv (337.9 MB) Graph csv IMPC mouse gene interacts with mouse ...
prokn.impc.impcmousegene.orthologous_to.impchumangene.edges ProKN IMPC Mouse-Human Ortholog Edges IMPC.ImpcMouseGene.IMPC_HUMAN_GENE_ORTHOLOGUES.ImpcHumanGene.edges.csv (5.5 MB) Graph csv IMPC mouse gene orthologous to human ...
prokn.impc.impcmousegene.impc_mouse_allele_id.impcallele.edges ProKN IMPC Mouse Allele ID Edges IMPC.ImpcMouseGene.IMPC_MOUSE_ALLELE_ID.ImpcAllele.edges.csv (2.3 MB) Graph csv IMPC mouse gene allele ID edges
prokn.impc.impcmousegene.impc_mouse_alleles.impcallele.edges ProKN IMPC Mouse Alleles Edges IMPC.ImpcMouseGene.IMPC_MOUSE_ALLELES.ImpcAllele.edges.csv (28.0 MB) Graph csv IMPC mouse gene allele membership edges
prokn.impc.imppublication.impc_alleles.impcallele.edges ProKN IMPC Publication Allele Edges IMPC.ImpcPublication.IMPC_ALLELES.ImpcAllele.edges.csv (4.0 MB) Graph csv IMPC publication allele edges
prokn.msigdb.msigdb.chr_band_contains_gene.gene.edges ProKN MSIGDB Chromosome Band Edges DDKG_MSIGDB.MSigDB.CHR_BAND_CONTAINS_GENE.Gene.edges.csv (4.9 MB) Graph csv MSIGDB chromosome band contains gene ...
prokn.msigdb.msigdb.has_marker_gene.gene.edges ProKN MSIGDB Marker Gene Edges DDKG_MSIGDB.MSigDB.HAS_MARKER_GENE.Gene.edges.csv (23.7 MB) Graph csv MSIGDB marker gene edges
prokn.msigdb.msigdb.has_signature_gene.gene.edges ProKN MSIGDB Signature Gene Edges DDKG_MSIGDB.MSigDB.HAS_SIGNATURE_GENE.Gene.edges.csv (1.6 MB) Graph csv MSIGDB signature gene edges
prokn.msigdb.msigdb.pathway_associated_with_gene.gene.edges ProKN MSIGDB Pathway Gene Edges DDKG_MSIGDB.MSigDB.PATHWAY_ASSOCIATED_WITH_GENE.Gene.edges.csv (120.1 MB) Graph csv MSIGDB pathway associated with gene e...
prokn.msigdb.msigdb.targets_expression_of_gene.gene.edges ProKN MSIGDB Targets Expression Edges DDKG_MSIGDB.MSigDB.TARGETS_EXPRESSION_OF_GENE.Gene.edges.csv (149.2 MB) Graph csv MSIGDB targets expression of gene edges
prokn.reactome.pathway.event_of.pathway.edges ProKN Reactome Pathway Event Edges Reactome.Pathway.PATHWAY_EVENT_OF.Pathway.edges.csv (1.0 MB) Graph csv Reactome pathway event hierarchy edges
prokn.lincs_p100.perturbagen.is_used_in.experiment.edges ProKN LINCS P100 Perturbagen Edges LINCS_P100.Perturbagen.IS_USED_IN.Experiment.edges.csv (529.1 KB) Graph csv LINCS P100 perturbagen experiment edges
prokn.lincs_p100.experiment.perturbation_effect.ptmsite.edges ProKN LINCS P100 Perturbation Effect Edges LINCS_P100.Experiment.PERTURBATION_EFFECT.PTMSite.edges.csv (50.1 MB) Graph csv LINCS P100 experiment perturbation ef...
prokn.lincs_p100.ptmsite.is_site.site.edges ProKN LINCS P100 PTM Site Mapping Edges LINCS_P100.PTMSite.IS_SITE.Site.edges.csv (980 B) Graph csv LINCS P100 PTM site is site of site e...
prokn.go.protein.acts_upstream_of.goterm.edges ProKN GO Acts Upstream Of Edges GO.Protein.ACTS_UPSTREAM_OF.GOTerm.edges.csv (155.2 KB) Graph csv GO protein acts upstream of GO term e...
prokn.go.protein.acts_upstream_of_negative_effect.goterm.edges ProKN GO Acts Upstream Negative Edges GO.Protein.ACTS_UPSTREAM_OF_NEGATIVE_EFFECT.GOTerm.edges.csv (10.2 KB) Graph csv GO protein acts upstream of negative ...
prokn.go.protein.acts_upstream_of_or_within.goterm.edges ProKN GO Acts Upstream Or Within Edges GO.Protein.ACTS_UPSTREAM_OF_OR_WITHIN.GOTerm.edges.csv (697.6 KB) Graph csv GO protein acts upstream of or within...
prokn.go.protein.acts_upstream_of_or_within_negative_effect.goterm.edges ProKN GO Acts Upstream Or Within Negative Edges GO.Protein.ACTS_UPSTREAM_OF_OR_WITHIN_NEGATIVE_EFFECT.GOTerm.edges.csv (4.2 KB) Graph csv GO protein acts upstream of or within...
prokn.go.protein.acts_upstream_of_or_within_positive_effect.goterm.edges ProKN GO Acts Upstream Or Within Positive Edges GO.Protein.ACTS_UPSTREAM_OF_OR_WITHIN_POSITIVE_EFFECT.GOTerm.edges.csv (13.6 KB) Graph csv GO protein acts upstream of or within...
prokn.go.protein.acts_upstream_of_positive_effect.goterm.edges ProKN GO Acts Upstream Positive Edges GO.Protein.ACTS_UPSTREAM_OF_POSITIVE_EFFECT.GOTerm.edges.csv (31.8 KB) Graph csv GO protein acts upstream of positive ...
prokn.go.protein.colocalizes_with.goterm.edges ProKN GO Colocalizes Edges GO.Protein.COLOCALIZES_WITH.GOTerm.edges.csv (255.4 KB) Graph csv GO protein colocalizes with GO term e...
prokn.go.protein.contributes_to.goterm.edges ProKN GO Contributes To Edges GO.Protein.CONTRIBUTES_TO.GOTerm.edges.csv (303.3 KB) Graph csv GO protein contributes to GO term edges
prokn.go.protein.enables.goterm.edges ProKN GO Enables Edges GO.Protein.ENABLES.GOTerm.edges.csv (50.7 MB) Graph csv GO protein enables GO term edges
prokn.interpro.protein.has_domain.domain.edges ProKN InterPro Domain Edges InterPro.Protein.HAS_DOMAIN.Domain.edges.csv (4.5 MB) Graph csv InterPro protein has domain edges
prokn.glygen.protein.has_isoform.isoform.edges ProKN GlyGen Protein Isoform Edges DDKG_PROTEOFORM.Protein.HAS_ISOFORM.Isoform.edges.csv (1.3 MB) Graph csv GlyGen protein isoform edges
prokn.iptmnet.protein.has_site.site.edges ProKN iPTMnet Protein Site Edges iPTMnet.Protein.HAS_SITE.Site.edges.csv (32.6 MB) Graph csv iPTMnet protein has site edges
prokn.glygen.protein.has_isoform.protein.edges ProKN GlyGen Protein Isoform Protein Edges DDKG_PROTEOFORM.Protein.HAS_ISOFORM.Protein.edges.csv (637.8 KB) Graph csv GlyGen protein isoform protein edges
prokn.uniprotkb.protein.has_site.site.edges ProKN UniProtKB Protein Site Edges UniProtKB.Protein.HAS_SITE.Site.edges.csv (25.6 MB) Graph csv UniProtKB protein has site edges
prokn.uniprotkb.protein.has_variant.variant.edges ProKN UniProtKB Variant Edges UniProtKB.Protein.HAS_VARIANT.Variant.edges.csv (18.8 MB) Graph csv UniProtKB protein variant edges
prokn.emind.protein.has_variant.variant.edges ProKN eMIND Variant Edges eMIND.Protein.HAS_VARIANT.Variant.edges.csv (58.7 KB) Graph csv eMIND protein variant edges
prokn.imex.protein.interacts_with.protein.edges ProKN IMEx Protein Interaction Edges IMEx.Protein.INTERACTS_WITH.Protein.edges.csv (346.5 MB) Graph csv IMEx protein interacts with protein e...
prokn.go.protein.involved_in.goterm.edges ProKN GO Involved In Edges GO.Protein.INVOLVED_IN.GOTerm.edges.csv (41.4 MB) Graph csv GO protein involved in GO term edges
prokn.go.protein.is_active_in.goterm.edges ProKN GO Active In Edges GO.Protein.IS_ACTIVE_IN.GOTerm.edges.csv (1.6 MB) Graph csv GO protein active in GO term edges
prokn.go.protein.located_in.goterm.edges ProKN GO Located In Edges GO.Protein.LOCATED_IN.GOTerm.edges.csv (48.4 MB) Graph csv GO protein located in GO term edges
prokn.go.protein.not_acts_upstream_of_or_within.goterm.edges ProKN GO Not Acts Upstream Or Within Edges GO.Protein.NOT_ACTS_UPSTREAM_OF_OR_WITHIN.GOTerm.edges.csv (1.8 KB) Graph csv GO protein not acts upstream of or wi...
prokn.go.protein.not_acts_upstream_of_or_within_negative_effect.goterm.edges ProKN GO Not Acts Upstream Negative Edges GO.Protein.NOT_ACTS_UPSTREAM_OF_OR_WITHIN_NEGATIVE_EFFECT.GOTerm.edges.csv (455 B) Graph csv GO protein not acts upstream of or wi...
prokn.go.protein.not_colocalizes_with.goterm.edges ProKN GO Not Colocalizes Edges GO.Protein.NOT_COLOCALIZES_WITH.GOTerm.edges.csv (3.3 KB) Graph csv GO protein not colocalizes with GO te...
prokn.go.protein.not_contributes_to.goterm.edges ProKN GO Not Contributes Edges GO.Protein.NOT_CONTRIBUTES_TO.GOTerm.edges.csv (3.1 KB) Graph csv GO protein not contributes to GO term...
prokn.go.protein.not_enables.goterm.edges ProKN GO Not Enables Edges GO.Protein.NOT_ENABLES.GOTerm.edges.csv (126.7 KB) Graph csv GO protein not enables GO term edges
prokn.go.protein.not_involved_in.goterm.edges ProKN GO Not Involved In Edges GO.Protein.NOT_INVOLVED_IN.GOTerm.edges.csv (139.8 KB) Graph csv GO protein not involved in GO term edges
prokn.go.protein.not_is_active_in.goterm.edges ProKN GO Not Active In Edges GO.Protein.NOT_IS_ACTIVE_IN.GOTerm.edges.csv (893 B) Graph csv GO protein not active in GO term edges
prokn.go.protein.not_located_in.goterm.edges ProKN GO Not Located In Edges GO.Protein.NOT_LOCATED_IN.GOTerm.edges.csv (51.5 KB) Graph csv GO protein not located in GO term edges
prokn.go.protein.not_part_of.goterm.edges ProKN GO Not Part Of Edges GO.Protein.NOT_PART_OF.GOTerm.edges.csv (4.6 KB) Graph csv GO protein not part of GO term edges
prokn.go.protein.part_of.goterm.edges ProKN GO Part Of Edges GO.Protein.PART_OF.GOTerm.edges.csv (3.5 MB) Graph csv GO protein part of GO term edges
prokn.imex.protein.participates_in.complex.edges ProKN IMEx Protein Participates In Complex Edges IMEx.Protein.PARTICIPATES_IN.Complex.edges.csv (17.9 MB) Graph csv IMEx protein participates in complex ...
prokn.reactome.protein.participates_in.pathway.edges ProKN Reactome Protein Pathway Edges Reactome.Protein.PARTICIPATES_IN.Pathway.edges.csv (16.3 MB) Graph csv Reactome protein participates in path...
prokn.iptmnet.protein.catalyzes.ptmsite.edges ProKN iPTMnet Protein Catalyzes PTM Site Edges iPTMnet.Protein.CATALYZES.PTMSite.edges.csv (3.9 MB) Graph csv iPTMnet protein catalyzes PTM site edges
prokn.emind.variant.associated_with.disease.edges ProKN eMIND Variant Disease Edges eMIND.Variant.ASSOCIATED_WITH.Disease.edges.csv (1.6 KB) Graph csv eMIND variant associated with disease...
prokn.emind.variant.impact.disease.edges ProKN eMIND Variant Impact Disease Edges eMIND.Variant.IMPACT.Disease.edges.csv (68.0 KB) Graph csv eMIND variant impact on disease edges
prokn.emind.variant.impact.protein.edges ProKN eMIND Variant Impact Protein Edges eMIND.Variant.IMPACT.Protein.edges.csv (1.3 KB) Graph csv eMIND variant impact on protein edges
prokn.explorer Protein Knowledge Network Explorer explorer Graphical Interface http Web explorer for the Protein Knowledg...
prokn.downloads Protein Knowledge Network Downloads downloads Product http Bulk downloads page listing current P...
prokn.api Protein Knowledge Network REST API restapi Programming Interface http REST API for the Protein Knowledge Ne...
prokn.mcp ProKN MCP Interface mcp Programming Interface http Hosted Model Context Protocol endpoin...
prokn.tpf Protein Knowledge Network TPF prokn Programming Interface http Triple Pattern Fragments endpoint for...
prokn.sparql Protein Knowledge Network SPARQL sparql Programming Interface http SPARQL endpoint for Protein Knowledge...

Details

Protein Knowledge Network

Protein Knowledge Network (ProKN) is a protein-centric knowledge graph that links CFDE datasets with curated biomedical resources spanning protein function, post-translational modification, pathway biology, gene expression, genotype-phenotype associations, and chemical perturbation data. The graph is designed to support cross-domain exploration of functional genomics and systems-level responses to perturbations.

The current public ProKN site exposes several complementary access paths. The network explorer supports interactive browsing, the REST API publishes resource-specific endpoints plus graph search operations, and the FRINK Triple Pattern Fragments endpoint provides linked-data access for graph-pattern queries. Bulk node and edge exports are indexed from the downloads page, which is the current authoritative landing page for public CSV exports.

Recent ProKN infrastructure also includes an MCP server implementation for AI clients. The MCP server source is published separately from the main website and documents both local deployment and the hosted MCP entry point used by compatible clients.

Access Points

Automated Evaluation

Is this information incorrect or incomplete? Request an update.

Created: January 23, 2026 | Last modified: September 23, 2026