is a Data Source.
The PRS Atlas is a comprehensive resource analyzing 162 polygenic risk scores (PRS) derived from genome-wide association studies against 551 heritable traits from the UK Biobank study (N=334,398). The atlas was developed to highlight putative causal relationships across the human phenome using Mendelian randomization approaches. PRS were constructed using independent SNPs (p<5×10⁻⁵) to evaluate associations with complex traits, providing insights into disease susceptibility and potential causal risk factors. The resource includes a web application for querying and visualizing associations between genetic liability and diverse health outcomes.
genomics, translational, biomedical
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infores:prsatlas
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| epigraphdb.graph | EpiGraphDB Graph Database | graph-database | GraphProduct | neo4j | Integrated graph knowledge base combi... |
The PRS Atlas is a comprehensive resource analyzing polygenic risk scores (PRS) for 162 traits derived from genome-wide association studies and their associations with 551 complex traits from the UK Biobank study. Developed by the MRC Integrative Epidemiology Unit at the University of Bristol, this atlas enables phenome-wide association studies using PRS to identify putative causal relationships between genetic liability and health outcomes. The resource was designed to facilitate causal inference through Mendelian randomization approaches and includes a web application for querying results, though the application may no longer be accessible.
Created: December 03, 2025 | Last modified: December 03, 2025