is a Data Source.
The PRS Atlas is a comprehensive resource analyzing 162 polygenic risk scores (PRS) derived from genome-wide association studies against 551 heritable traits from the UK Biobank study (N=334,398). The atlas was developed to highlight putative causal relationships across the human phenome using Mendelian randomization approaches. PRS were constructed using independent SNPs (p<5×10⁻⁵) to evaluate associations with complex traits, providing insights into disease susceptibility and potential causal risk factors. The resource includes a web application for querying and visualizing associations between genetic liability and diverse health outcomes.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| prsatlas.dryad | PRS Atlas Dryad Archive | dryad.h18c66b | Product | http | Dryad archive for PRS Atlas results, ... |
| prsatlas.results_5e05 ⚠ | PRS Atlas Results P less than 5e-05 | 83029 | Product | txt | PRS Atlas results using the P less th... |
| prsatlas.results_5e08 ⚠ | PRS Atlas Results P less than 5e-08 | 83030 | Product | txt | PRS Atlas results using the P less th... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| epigraphdb.graph | EpiGraphDB Graph Database | graph-database | GraphProduct | neo4j | had primary source | Integrated graph knowledge base combi... |
The PRS Atlas is a comprehensive resource analyzing polygenic risk scores (PRS) for 162 traits derived from genome-wide association studies and their associations with 551 complex traits from the UK Biobank study. Developed by the MRC Integrative Epidemiology Unit at the University of Bristol, this atlas enables phenome-wide association studies using PRS to identify putative causal relationships between genetic liability and health outcomes. The original web application is no longer accessible, but a copy of the result data is archived in Dryad.
Created: December 03, 2025 | Last modified: June 02, 2026