prsatlas

is a Data Source.

The PRS Atlas is a comprehensive resource analyzing 162 polygenic risk scores (PRS) derived from genome-wide association studies against 551 heritable traits from the UK Biobank study (N=334,398). The atlas was developed to highlight putative causal relationships across the human phenome using Mendelian randomization approaches. PRS were constructed using independent SNPs (p<5×10⁻⁵) to evaluate associations with complex traits, providing insights into disease susceptibility and potential causal risk factors. The resource includes a web application for querying and visualizing associations between genetic liability and diverse health outcomes.

This resource is inactive. It may not be actively maintained.

Domains

genomics, translational, biomedical

License

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Homepage

Repository

Unknown

Infores ID

infores:prsatlas

FAIRsharing ID

Unknown

⚠ The web application at http://mrcieu.mrsoftware.org/PRS_atlas/ may no longer be accessible

Contacts

MRC Integrative Epidemiology Unit, University of Bristol

URL: https://www.bristol.ac.uk/integrative-epidemiology-unit/

Publications

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome Preferred

Products

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Created: December 03, 2025 | Last modified: December 03, 2025