is a Knowledge Graph.
ReproTox-KG is a knowledge graph for structural birth defects and reproductive toxicology that integrates literature-derived and chemical evidence to support exploration of drug-birth defect relationships.
No external IDs available
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| reprotox-kg.portal | ReproTox-KG Explorer | reprotox-kg | Graphical Interface | http | Public web interface for querying and... |
| reprotox-kg.code | ReproTox-KG Source Repository | Reprotox-KG | Process | http | Source repository for the ReproTox-KG... |
| reprotox-kg.schema | ReproTox-KG Schema | schema.json (15.2 KB) | Product | json | Knowledge graph schema definition use... |
| reprotox-kg.data | ReproTox-KG Downloads | downloads | Product | http | Downloads page listing the ReproTox-K... |
| reprotox-kg.graph.core | ReproTox-KG Core Graph | reprotox_serialization.valid.json (1.6 MB) | Graph | json | Core ReproTox-KG graph linking birth ... |
| reprotox-kg.graph.sigcom-lincs | ReproTox-KG SigCom LINCS Drug-Gene Graph | sigcom_lincs_serialization.valid.json (109.3 MB) | Graph | json | Drug-to-gene up- and down-regulation ... |
| reprotox-kg.graph.drug-similarity | ReproTox-KG LINCS Drug Similarity Graph | sigcom_lincs_drug_similarity.valid.json (14.3 MB) | Graph | json | Drug-drug cosine similarity edges com... |
| reprotox-kg.graph.faers-male | ReproTox-KG FAERS Male Graph | drugsto_faers_male.valid.json (199.9 KB) | Graph | json | Drug to birth defect associations fro... |
| reprotox-kg.graph.faers-female | ReproTox-KG FAERS Female Graph | drugsto_faers_female.valid.json (206.1 KB) | Graph | json | Drug to birth defect associations fro... |
| reprotox-kg.graph.hpo | ReproTox-KG HPO Graph | hpo.valid.json (48.5 MB) | Graph | json | Gene to birth defect phenotype associ... |
| reprotox-kg.graph.archs4 | ReproTox-KG ARCHS4 Coexpression Graph | archs4_coexpression.valid.json (89.4 MB) | Graph | json | Gene-gene positive and negative coexp... |
| reprotox-kg.graph.drugshot-hpo | ReproTox-KG DrugShot HPO-Drug Graph | Drugshot_HPO_to_Drug.valid.json (8.5 MB) | Graph | json | Birth defect phenotype to drug associ... |
| reprotox-kg.graph.geneshot-hpo | ReproTox-KG GeneShot HPO-Gene Graph | Geneshot_HPO_to_Gene.valid.json (6.9 MB) | Graph | json | Birth defect phenotype to gene associ... |
| reprotox-kg.graph.idg | ReproTox-KG IDG Drug Target Graph | idg_drug_targets.valid.json (6.1 MB) | Graph | json | Drug-target edges from the Illuminati... |
ReproTox-KG is a knowledge graph focused on reproductive toxicology and structural birth defects.
ReproTox-KG has BirthDefect, Gene, and Drug nodes. Its edges come from ARCHS4 coexpression, DrugEnrichr, DrugShot, FAERS, GeneShot, the Human Phenotype Ontology, IDG drug targets, and SigCom LINCS L1000 signatures. The graph serializations on the downloads page are dated November 2022; the repository was last updated in August 2023. Neither the site nor the repository states a license for the data.
The legacy reprotox-kg.net endpoints appear to have been retired. This entry now points to the currently maintained Ma’ayan Lab resources and removes stale URL-check warnings tied to the abandoned domain.
Created: September 23, 2025 | Last modified: October 10, 2026