rxnorm

is a Data Source.

It is part of the OMOP collection.

RxNorm is the National Library of Medicine's standardized nomenclature for clinical drugs, providing normalized names and unique concept identifiers (RxCUIs) for medications. Developed to support interoperability between healthcare systems, RxNorm links its standardized drug names to the vocabularies commonly used in pharmacy management and drug interaction software, including First Databank, Micromedex, Multum, and Gold Standard Drug Database. By providing links between these diverse vocabularies, RxNorm enables seamless communication between systems that do not use the same software or terminology. RxNorm organizes drug information into a hierarchy of term types representing different levels of specificity, from ingredients through clinical drug components to specific branded and generic products. The nomenclature covers prescription drugs, over-the-counter medications, and now includes the United States Pharmacopeia Compendial Nomenclature containing all Active Pharmaceutical Ingredients. RxNorm is updated monthly with new drug products, revisions to existing entries, and retirement of obsolete terms to maintain currency with the evolving pharmaceutical landscape. The system supports multiple use cases including electronic health records, e-prescribing, pharmacy management systems, drug interaction checking, clinical decision support, and public health surveillance.

Domains

health

License

Warning: No license entered

Homepage

rxnorm

Repository

Unknown

Infores ID

infores:rxnorm

FAIRsharing ID

Unknown

Product Summary

Publications

Preferred

Products

From this Resource
ID Name URL Category Format Description
rxnorm.data_files RxNorm Data Files rxnormfiles.html Product http Monthly releases of RxNorm data files...
rxnorm.api RxNorm API RxNormAPIs.html ProgrammingInterface http RESTful web services providing progra...
rxnorm.rxnav RxNav Browser RxNav GraphicalInterface http Interactive web browser for searching...
rxnorm.rxclass RxClass RxClass GraphicalInterface http Tool for exploring drug class hierarc...
rxnorm.rxmix RxMix RxMix ProgrammingInterface http Interactive tool allowing users to co...
rxnorm.rxnav_in_a_box RxNav-in-a-Box RxNav-in-a-Box.html Product http Locally installable package containin...
ndfrt.rxnorm VANDF in RxNorm rxnorm Product VANDF data integrated into RxNorm
From other Resources
ID Name URL Category Format Description
athena.vocabularies Athena Vocabulary Downloads list Product csv Downloadable standardized vocabulary ...

Details

RxNorm

Overview

RxNorm is the National Library of Medicine’s standardized nomenclature for clinical drugs, serving as a foundational terminology for drug information exchange in healthcare IT systems. As a free, publicly available resource, RxNorm provides normalized names and unique identifiers for clinical drugs and links these names to the vocabularies used by pharmacy management and drug interaction software systems.

Information Resource ID

This resource has the Information Resource identifier: infores:rxnorm

Purpose and Scope

RxNorm was developed to solve a critical interoperability problem in healthcare: different information systems use different drug naming conventions, making it difficult to communicate medication information across systems. By serving as a common language and providing links between proprietary drug vocabularies, RxNorm enables:

  • Electronic health record systems to exchange medication information
  • E-prescribing systems to communicate prescriptions accurately
  • Pharmacy systems to process and dispense medications correctly
  • Clinical decision support systems to check for drug interactions
  • Public health systems to monitor medication usage and safety

Drug Terminology Structure

RxNorm organizes drug information hierarchically through term types:

  • Ingredients: Active pharmaceutical ingredients (e.g., acetaminophen)
  • Precise Ingredients: Ingredients with specific form (e.g., acetaminophen oral)
  • Clinical Drug Components: Ingredient + strength (e.g., acetaminophen 325 mg)
  • Clinical Drugs: Generic formulations (e.g., acetaminophen 325 mg oral tablet)
  • Branded Drugs: Brand name products (e.g., Tylenol 325 mg oral tablet)

Each concept receives a unique RxNorm Concept Unique Identifier (RxCUI) enabling consistent referencing across systems.

Content and Coverage

  • Prescription medications: Full coverage of FDA-approved prescription drugs
  • Over-the-counter products: Common OTC medications
  • USP Compendial Nomenclature: All Active Pharmaceutical Ingredients from the United States Pharmacopeia
  • Links to proprietary vocabularies: Connections to First Databank, Micromedex, Multum, Gold Standard Drug Database, and others
  • Monthly updates: New products, revisions, and retirements to maintain currency

RxNav Suite of Tools

The RxNav ecosystem extends RxNorm with user-friendly tools and services:

RxNav Browser

Interactive web application for searching and exploring RxNorm drug concepts, viewing relationships, properties, and status information with multiple visualization options.

RxClass

Exploration of drug class hierarchies from multiple classification systems including ATC, MeSH, FMTSME, EPC, and disease-specific classes, showing RxNorm drug members for each class.

RxMix

Interactive platform allowing users to combine multiple API functions to create custom drug information applications and workflows.

RxNav-in-a-Box

Locally installable version of RxNav, RxClass, RxMix, and companion APIs for institutions requiring offline access or local deployment.

Data Access

RxNorm data is freely available through:

  • Monthly data file releases: Complete RxNorm vocabulary in RRF and other formats
  • RESTful APIs: Comprehensive web services for programmatic access
  • Interactive browsers: Web-based tools for human exploration
  • UMLS integration: Available as part of the Unified Medical Language System

Technical Integration

RxNorm is required by the U.S. Office of the National Coordinator for Health Information Technology (ONC) for use in certified EHR systems. The terminology supports:

  • HL7 messaging standards
  • FHIR resources for medications
  • CDA documents
  • NCPDP SCRIPT e-prescribing standards

Maintenance and Updates

RxNorm is updated monthly following a regular release schedule, incorporating:

  • New FDA-approved drug products
  • Revisions to existing drug concepts
  • Retirement of discontinued products
  • Updates to linked vocabularies
  • Improvements to relationships and hierarchies

Support and Documentation

Comprehensive documentation, training materials, video tutorials, and technical support are available through the NLM. Users can access FAQs, technical documentation, learning resources, and direct support from the RxNorm team.

Is this information incorrect or incomplete? Request an update.

Created: November 08, 2025 | Last modified: April 10, 2026