is a Data Source.
It is part of the NAMs collection.
Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) is an online US EPA screening tool for extrapolating chemical toxicity information from data-rich model organisms (e.g., human, mouse, rat, zebrafish) to thousands of non-target species. Many chemicals act through known protein targets. Using protein sequence and structure data from the NCBI protein database, SeqAPASS compares amino acid sequence and protein structure similarity across species to predict whether those targets are present, and so whether the species are likely to be susceptible. Version 8 can also generate protein structures across species and report metrics on their quality.
U.S. Government Work (public domain)
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No external IDs available
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| seqapass.app | SeqAPASS Web Application | seqapass | Graphical Interface | http | The SeqAPASS web application for cros... |
| seqapass.user-guide | SeqAPASS User Guide | seqapass-user-guide | Documentation | http | SeqAPASS V8 user guide describing how... |
SeqAPASS is a fast, online screening tool from the US EPA that lets researchers and regulators extrapolate toxicity information across species. Toxicity data are plentiful for a few model organisms and scarce for most other plants and animals. SeqAPASS addresses this gap by checking whether the protein target a chemical acts on is conserved in non-target species, such as pollinators or threatened and endangered species. It supports cross-species extrapolation as a new approach methodology (NAM) and reduces reliance on animal testing.
SeqAPASS is developed by the US EPA. As a work of the U.S. federal government it is generally in the public domain (U.S. Government Work). The underlying sequence data come from NCBI.
Created: October 19, 2026 | Last modified: October 19, 2026