sfld

is a Data Source.

The Structure-Function Linkage Database (SFLD) is a resource that links enzyme sequence, structure, and chemical function. It organizes functionally diverse enzyme superfamilies by mapping the specific chemical reactions catalyzed by members to the conserved structural features that enable those reactions.

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Domains

proteomics, chemistry and biochemistry

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Homepage

sfld

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Product Summary

Products

From this Resource
ID Name URL Category Format Description
sfld.site SFLD Website sfld.rbvi.ucsf.edu GraphicalInterface http Web interface for browsing enzyme sup...
From other Resources
ID Name URL Category Format Relation Description
genecards.web.interface GeneCards Web Interface www.genecards.org GraphicalInterface http had primary source Web-based interface for searching and...

Details

Structure-Function Linkage Database

The Structure-Function Linkage Database (SFLD) is a manually curated resource that describes the relationships between the sequences, structures, and chemical functions of enzymes within functionally diverse superfamilies. It hierarchically links the partial reactions and conserved active-site features that underlie enzyme chemistry.

Content includes:

  • Functionally diverse enzyme superfamilies organized by subgroup and family
  • Mappings between conserved structural features and catalyzed chemical reactions
  • Sequence and structure annotations supporting functional inference

GeneCards integrates enzyme structure-function relationships from SFLD.

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Created: June 17, 2026 | Last modified: June 17, 2026