Toxin and Toxin Target Database (T3DB)

Overview

The Toxin and Toxin Target Database (T3DB), also called the Toxic Exposome Database, is a curated bioinformatics resource developed by the Wishart lab that pairs detailed toxin records with comprehensive information about their molecular targets. Each toxin is described across more than 90 data fields and linked to the proteins, genes, or other targets it acts upon, together with the mechanisms by which it exerts its toxic effects.

Scope & Content

• Thousands of toxins, including environmental pollutants, pesticides, drugs, and food toxins
• Chemical, physical, and toxicological property annotations for each toxin
• Toxin target records (proteins, genes, and other molecular targets)
• Toxin-target associations describing mechanisms of toxicity
• Cross-references to external chemical and biomedical resources

Use Cases

• Computational and mechanistic toxicology research
• Linking chemical exposures to molecular targets and adverse effects
• Building integrated knowledge graphs of toxins, targets, and mechanisms
• Serving as an upstream primary source for downstream resources such as PharmDB

Access

T3DB is available through its public web portal at http://www.t3db.ca/, which supports browsing and searching of toxin and target records. Bulk data downloads (e.g., XML and SDF) are provided via the downloads page; use is subject to the T3DB terms of use.

Citation & Attribution

When using T3DB, cite Wishart D et al., “T3DB: the toxic exposome database,” Nucleic Acids Research, 2015 (doi:10.1093/nar/gku1004).