is a Data Source.
It is part of the NAMs collection.
Tox21 (Toxicology in the 21st Century) is a US federal collaboration among the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS), the US Environmental Protection Agency (EPA), the National Toxicology Program at the National Institute of Environmental Health Sciences (NTP/NIEHS), and the US Food and Drug Administration (FDA). The consortium uses quantitative high-throughput screening to test a library of approximately 10,000 chemicals, including environmental compounds and approved drugs, against a panel of biological assays that probe nuclear-receptor signaling and cellular stress-response pathways. The resulting data are used to predict potential toxicity and to prioritize chemicals for further, more targeted testing.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| tox21.data | Tox21 Data and Resources | resources | Product | mixed | Tox21 data and resources, including q... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| biobricks-tox21.graph | BioBricks Tox21 Knowledge Graph | biobricks-okg | Graph | ttl | was derived from | RDF knowledge graph repackaging EPA/N... |
| comptox-dashboard.portal | CompTox Chemicals Dashboard Web Application | dashboard | Graphical Interface | http | was derived from | Web interface to the CompTox Chemical... |
Tox21 (Toxicology in the 21st Century) is a collaboration among US federal agencies – NIH/NCATS, the EPA, NTP/NIEHS, and the FDA – that applies quantitative high-throughput screening to characterize the potential toxicity of chemicals. The program screens a library of roughly 10,000 chemicals against assays measuring activity in nuclear-receptor signaling and cellular stress-response pathways, generating data used to predict human health effects and prioritize compounds for further testing.
Created: July 01, 2026 | Last modified: October 19, 2026