is a Data Source.
It is part of the NAMs collection.
The Toxicity Reference Database (ToxRefDB) is a US EPA database of in vivo animal toxicity study data from thousands of guideline or guideline-like studies covering over 1,000 chemicals. Study designs, doses, treatment-related effects, and endpoints are recorded with a controlled vocabulary, making the data structured and computable. ToxRefDB supports retrospective and predictive toxicology analyses, including the validation and benchmarking of in vitro high-throughput screening and other new approach methodologies (NAMs).
No external IDs available
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| toxrefdb.download | ToxRefDB Database Download | 6062545 | Product | mixed | ToxRefDB database package and associa... |
| toxrefdb.repository | ToxRefDB GitHub Repository | CompTox-ToxRefDB | Product | http | GitHub repository for US EPA's Toxici... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| comptox-dashboard.portal | CompTox Chemicals Dashboard Web Application | dashboard | Graphical Interface | http | was derived from | Web interface to the CompTox Chemical... |
| comptox-dashboard.downloads | Downloadable Computational Toxicology Data | downloadable-computational-toxicology-data | Product | mixed | was derived from | EPA's downloadable computational toxi... |
| toxvaldb.download | ToxValDB Database Download | 20394501 | Product | mixed | was derived from | ToxValDB database releases (current v... |
| toxvaldb.main | toxvaldbmain R Package | toxvaldbmain | Process | r | was derived from | R package of scripts that transform s... |
The Toxicity Reference Database (ToxRefDB) is maintained by the US EPA Center for Computational Toxicology and Exposure. It holds structured in vivo animal toxicity study data from guideline and guideline-like studies. EPA uses it as a reference set of in vivo outcomes, against which in vitro high-throughput screening and other new approach methodologies (NAMs) can be validated and benchmarked.
The ToxRefDB files on EPA’s figshare are released under CC0. As an EPA product, ToxRefDB is also a U.S. Government Work.
Created: October 19, 2026 | Last modified: October 19, 2026