is a Data Source.
TRRUST (Transcriptional Regulatory Relationships Unraveled by Sentence-based Text mining) is a manually curated database of human and mouse transcriptional regulatory networks. Its interactions are extracted from sentences in PubMed abstracts using sentence-based text mining followed by manual expert curation, capturing transcription factor (TF) to target-gene relationships along with the mode of regulation (activation, repression, or unknown). The v2 release contains 8,444 human and 6,552 mouse TF-target regulatory interactions derived from over 11,000 PubMed articles, each linked to the supporting literature evidence. TRRUST serves as an upstream primary source for derived regulatory-network resources such as DoRothEA.
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| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| trrust.web | TRRUST Web Resource | trrust | Product | http | TRRUST web resource for browsing and ... |
| trrust.human.tsv | TRRUST Human Interactions (TSV) | trrust_rawdata.human.tsv (290.7 KB) | Product | tsv | TRRUST v2 human transcription factor-... |
| trrust.mouse.tsv | TRRUST Mouse Interactions (TSV) | trrust_rawdata.mouse.tsv (215.2 KB) | Product | tsv | TRRUST v2 mouse transcription factor-... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| dorothea.graph | DoRothEA Regulon Graph | v1.0.0 | GraphProduct | ❔ | had primary source | Core TF–target regulon knowledge grap... |
TRRUST is a manually curated data source of human and mouse transcriptional regulatory interactions, providing transcription factor-target relationships with their mode of regulation and supporting literature evidence. It is an upstream primary source of derived regulatory-network resources such as DoRothEA.
Created: June 18, 2026 | Last modified: June 18, 2026