is a Data Source.
TRRUST (Transcriptional Regulatory Relationships Unraveled by Sentence-based Text mining) is a manually curated database of human and mouse transcriptional regulatory networks. Its interactions are extracted from sentences in PubMed abstracts using sentence-based text mining followed by manual expert curation, capturing transcription factor (TF) to target-gene relationships along with the mode of regulation (activation, repression, or unknown). The v2 release contains 8,444 human and 6,552 mouse TF-target regulatory interactions derived from over 11,000 PubMed articles, each linked to the supporting literature evidence. TRRUST serves as an upstream primary source for derived regulatory-network resources such as DoRothEA.
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| trrust.web | TRRUST Web Resource | trrust | Product | http | TRRUST web resource for browsing and ... |
| trrust.human.tsv | TRRUST Human Interactions (TSV) | trrust_rawdata.human.tsv (290.7 KB) | Product | tsv | TRRUST v2 human transcription factor-... |
| trrust.mouse.tsv | TRRUST Mouse Interactions (TSV) | trrust_rawdata.mouse.tsv (215.2 KB) | Product | tsv | TRRUST v2 mouse transcription factor-... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| dorothea.graph | DoRothEA Regulon Graph | v1.0.0 | Graph | r | had primary source | Core TF–target regulon knowledge grap... |
| tflink.downloads | TFLink Downloads | download | Product | http | had primary source | Download page listing interaction tab... |
| tflink.interactions.human | TFLink Human Interactions | TFLink_Homo_sapiens_interactions_All_simpleFormat_v1.0.tsv.gz (295.1 MB) | Graph | tsv | had primary source | All TF-target gene interactions for H... |
| tflink.interactions.mouse | TFLink Mouse Interactions | TFLink_Mus_musculus_interactions_All_simpleFormat_v1.0.tsv.gz (166.9 MB) | Graph | tsv | had primary source | All TF-target gene interactions for M... |
| tflink.interactions.rat | TFLink Rat Interactions | TFLink_Rattus_norvegicus_interactions_All_simpleFormat_v1.0.tsv (12.4 MB) | Graph | tsv | had primary source | All TF-target gene interactions for R... |
| tflink.interactions.zebrafish | TFLink Zebrafish Interactions | TFLink_Danio_rerio_interactions_All_simpleFormat_v1.0.tsv (3.3 MB) | Graph | tsv | had primary source | All TF-target gene interactions for D... |
| tflink.interactions.fly | TFLink Fruit Fly Interactions | TFLink_Drosophila_melanogaster_interactions_All_simpleFormat_v1.0.tsv (53.9 MB) | Graph | tsv | had primary source | All TF-target gene interactions for D... |
| tflink.interactions.worm | TFLink Nematode Interactions | TFLink_Caenorhabditis_elegans_interactions_All_simpleFormat_v1.0.tsv (46.2 MB) | Graph | tsv | had primary source | All TF-target gene interactions for C... |
| tflink.interactions.yeast | TFLink Yeast Interactions | TFLink_Saccharomyces_cerevisiae_interactions_All_simpleFormat_v1.0.tsv (42.1 MB) | Graph | tsv | had primary source | All TF-target gene interactions for S... |
| tflink.interactions.human.mitab | TFLink Human Interactions (MITAB) | TFLink_Homo_sapiens_interactions_All_mitab_v1.0.tsv.gz (218.9 MB) | Graph | psi_mi_mitab | had primary source | All human TF-target gene interactions... |
| tflink.gmt.human | TFLink Human TF Target Gene Sets | TFLink_Homo_sapiens_interactions_All_GMT_ncbiGeneID_v1.0.gmt (36.1 MB) | Product | tsv | had primary source | Human gene sets, one per transcriptio... |
| tflink.binding-sites.human | TFLink Human Binding Sites | TFLink_Homo_sapiens_bindingSites_All_annotation_v1.0.tsv.gz (153.1 MB) | Product | tsv | had primary source | Genomic locations of human TF binding... |
| tflink.binding-sites.human.gff3 | TFLink Human Binding Sites (GFF3) | TFLink_Homo_sapiens_bindingSites_All_annotation_v1.0.gff3 (913.7 MB) | Product | gff | had primary source | Human TF binding site locations as a ... |
| tflink.binding-sites.human.fasta | TFLink Human Binding Site Sequences | TFLink_Homo_sapiens_bindingSites_All_v1.0.fasta (1.1 GB) | Product | fasta | had primary source | Nucleotide sequences of human TF bind... |
TRRUST is a manually curated data source of human and mouse transcriptional regulatory interactions, providing transcription factor-target relationships with their mode of regulation and supporting literature evidence. It is an upstream primary source of derived regulatory-network resources such as DoRothEA.
Created: June 18, 2026 | Last modified: September 23, 2026