wormbase

is a Data Source.

WormBase is an online biological database providing comprehensive genomic and biological information about C. elegans and related nematodes, including annotated genomes, gene structures, functional annotations, genetic maps, gene expression data, protein interactions, RNAi phenotypes, and curated literature.

Domains

genomics, organisms, anatomy and development

Homepage

wormbase

Repository

GitHub

Infores ID

infores:wormbase

FAIRsharing ID

Unknown

Product Summary

Products

From this Resource
ID Name URL Category Format Description
wormbase.portal WormBase Web Portal www.wormbase.org GraphicalInterface http Primary web portal for browsing and s...
wormbase.gbrowse WormBase GBrowse c_elegans GraphicalInterface Genome browser for visualizing genes,...
wormbase.api WormBase REST API API-REST ProgrammingInterface REST API providing programmatic acces...
wormbase.wormmine WormMine begin.do GraphicalInterface WormMine InterMine instance for compl...
wormbase.textpresso Textpresso tfw.cgi GraphicalInterface Full-text search tool for querying C....
wormbase.ftp WormBase FTP Downloads wormbase Product FTP server providing bulk downloads o...
wormbase.parasite WormBase ParaSite parasite.wormbase.org GraphicalInterface Sub-portal hosting approximately 100 ...
From other Resources
ID Name URL Category Format Description
string.protein.links STRING Protein Links protein.links.v12.0.txt.gz (128.7 GB) GraphProduct txt protein network data (full network, s...
string.protein.links.detailed STRING Protein Links Detailed protein.links.detailed.v12.0.txt.gz (189.6 GB) GraphProduct txt protein network data (full network, i...
string.protein.links.full STRING Protein Links Full protein.links.full.v12.0.txt.gz (199.6 GB) GraphProduct txt protein network data (full network, i...
string.protein.physical.links STRING Protein Physical Links protein.physical.links.v12.0.txt.gz (11.1 GB) GraphProduct txt protein network data (physical subnet...
string.protein.physical.links.detailed STRING Protein Physical Links Detailed protein.physical.links.detailed.v12.0.txt.gz (13.8 GB) GraphProduct txt protein network data (physical subnet...
string.protein.physical.links.full STRING Protein Physical Links Full protein.physical.links.full.v12.0.txt.gz (14.5 GB) GraphProduct txt protein network data (physical subnet...
string.cog.links STRING COG Links COG.links.v12.0.txt.gz (176.8 MB) GraphProduct txt association scores between orthologou...
string.cog.links.detailed STRING COG Links Detailed COG.links.detailed.v12.0.txt.gz (238.7 MB) GraphProduct txt association scores (incl. subscores p...
string.database STRING Database Network Schema network_schema.v12.0.sql.gz (262.2 GB) GraphProduct full database, part II: the networks ...

Details

WormBase

Overview

WormBase is a comprehensive biological database and online resource for the biology and genome of the nematode model organism Caenorhabditis elegans and related nematode species. The database integrates genomic sequences, gene structures, functional annotations, genetic and physical maps, gene expression patterns, protein-protein interactions, RNAi phenotypes, mutant alleles, and curated literature.

Primary Organism

WormBase primarily focuses on Caenorhabditis elegans but also includes data for:

  • C. briggsae, C. remanei, C. brenneri, C. angaria, C. japonica
  • Pristionchus pacificus
  • Parasitic nematodes including Haemonchus contortus, Brugia malayi, Meloidogyne hapla, and Meloidogyne incognita

Data Content

WormBase comprises:

  • Annotated genomes with hand-curated gene structures
  • ~20,500 protein-coding genes and ~16,000 non-coding genes for C. elegans
  • Gene family classifications and orthology relationships
  • Comprehensive phenotype and allele information
  • Whole-genome RNAi screens
  • Gene expression profiles from microarrays, RNA-Seq, and GFP reporter studies
  • Complete cell lineage and nervous system wiring diagram
  • Protein-protein interaction networks
  • Genetic regulatory relationships
  • Searchable bibliography of C. elegans research

Tools & Access

  • Web Portal: Interactive browsing and search interface
  • GBrowse: Genome browser for visualizing genomic features
  • WormMine: InterMine-based data mining facility for complex queries
  • REST API: Programmatic access to all WormBase data
  • Textpresso: Literature text mining and search
  • FTP Downloads: Bulk data files including genome assemblies and annotations
  • WormBase ParaSite: Sub-portal for parasitic helminth genomes

Management & Funding

WormBase is a collaboration among the European Bioinformatics Institute, Wellcome Trust Sanger Institute, Ontario Institute for Cancer Research, Washington University in St. Louis, and California Institute of Technology. Supported by the National Institutes of Health (P41-HG002223) and the British Medical Research Council.

Part of Alliance

WormBase is a founding member of the Alliance of Genome Resources, which integrates data across model organism databases.

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Created: October 30, 2025 | Last modified: October 30, 2025