is a Data Source.
YEASTRACT (Yeast Search for Transcriptional Regulators And Consensus Tracking) is a curated repository of documented regulatory associations between transcription factors (TFs) and target genes, and of TF binding sites, in Saccharomyces cerevisiae, compiled by manual curation of the published literature. It is now part of the YEASTRACT+ portal, which also hosts PathoYeastract (pathogenic Candida species and Cryptococcus neoformans), N.C.Yeastract (non-conventional biotechnological yeasts), and CommunityYeastract (automatically generated databases for further species and strains). YEASTRACT+ provides tools to search regulators, targets, and associations, analyze promoter motifs, rank genes by TF or GO term, compare regulatory networks across species through orthology, and combine regulatory data with genome-scale metabolic models. In 2023 the portal held over 300,000 documented regulatory associations across 11 yeast species, about 215,000 of them for S. cerevisiae.
gene regulation, genomics, microbiology, model organisms, organisms
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No external IDs available
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| yeastract.portal | YEASTRACT+ Portal | yeastract-plus.org | Graphical Interface | http | YEASTRACT+ portal giving access to th... |
| yeastract.scerevisiae | Yeastract (S. cerevisiae) | scerevisiae | Graphical Interface | http | Yeastract web interface for Saccharom... |
| yeastract.pathoyeastract | PathoYeastract | pathoyeastract | Graphical Interface | http | PathoYeastract web interface with cur... |
| yeastract.ncyeastract | N.C.Yeastract | ncyeastract | Graphical Interface | http | N.C.Yeastract web interface with cura... |
| yeastract.community | CommunityYeastract | community | Graphical Interface | http | CommunityYeastract, a set of automati... |
| ID | Name | URL | Category | Format | Relation | Description |
|---|---|---|---|---|---|---|
| tflink.downloads | TFLink Downloads | download | Product | http | had primary source | Download page listing interaction tab... |
| tflink.interactions.human | TFLink Human Interactions | TFLink_Homo_sapiens_interactions_All_simpleFormat_v1.0.tsv.gz (295.1 MB) | Graph | tsv | had primary source | All TF-target gene interactions for H... |
| tflink.interactions.mouse | TFLink Mouse Interactions | TFLink_Mus_musculus_interactions_All_simpleFormat_v1.0.tsv.gz (166.9 MB) | Graph | tsv | had primary source | All TF-target gene interactions for M... |
| tflink.interactions.rat | TFLink Rat Interactions | TFLink_Rattus_norvegicus_interactions_All_simpleFormat_v1.0.tsv (12.4 MB) | Graph | tsv | had primary source | All TF-target gene interactions for R... |
| tflink.interactions.zebrafish | TFLink Zebrafish Interactions | TFLink_Danio_rerio_interactions_All_simpleFormat_v1.0.tsv (3.3 MB) | Graph | tsv | had primary source | All TF-target gene interactions for D... |
| tflink.interactions.fly | TFLink Fruit Fly Interactions | TFLink_Drosophila_melanogaster_interactions_All_simpleFormat_v1.0.tsv (53.9 MB) | Graph | tsv | had primary source | All TF-target gene interactions for D... |
| tflink.interactions.worm | TFLink Nematode Interactions | TFLink_Caenorhabditis_elegans_interactions_All_simpleFormat_v1.0.tsv (46.2 MB) | Graph | tsv | had primary source | All TF-target gene interactions for C... |
| tflink.interactions.yeast | TFLink Yeast Interactions | TFLink_Saccharomyces_cerevisiae_interactions_All_simpleFormat_v1.0.tsv (42.1 MB) | Graph | tsv | had primary source | All TF-target gene interactions for S... |
| tflink.interactions.human.mitab | TFLink Human Interactions (MITAB) | TFLink_Homo_sapiens_interactions_All_mitab_v1.0.tsv.gz (218.9 MB) | Graph | psi_mi_mitab | had primary source | All human TF-target gene interactions... |
| tflink.gmt.human | TFLink Human TF Target Gene Sets | TFLink_Homo_sapiens_interactions_All_GMT_ncbiGeneID_v1.0.gmt (36.1 MB) | Product | tsv | had primary source | Human gene sets, one per transcriptio... |
| tflink.binding-sites.human | TFLink Human Binding Sites | TFLink_Homo_sapiens_bindingSites_All_annotation_v1.0.tsv.gz (153.1 MB) | Product | tsv | had primary source | Genomic locations of human TF binding... |
| tflink.binding-sites.human.gff3 | TFLink Human Binding Sites (GFF3) | TFLink_Homo_sapiens_bindingSites_All_annotation_v1.0.gff3 (913.7 MB) | Product | gff | had primary source | Human TF binding site locations as a ... |
| tflink.binding-sites.human.fasta | TFLink Human Binding Site Sequences | TFLink_Homo_sapiens_bindingSites_All_v1.0.fasta (1.1 GB) | Product | fasta | had primary source | Nucleotide sequences of human TF bind... |
YEASTRACT (Yeast Search for Transcriptional Regulators And Consensus Tracking) is a curated database of transcription regulation in Saccharomyces cerevisiae, first described in 2006. Since 2020 it has been part of the YEASTRACT+ portal, maintained at Instituto Superior Técnico, Universidade de Lisboa, and most recently described in Teixeira et al. 2023 (Nucleic Acids Research).
The portal holds documented regulatory associations between transcription factors (TFs) and target genes, along with TF binding sites, manually curated from the published literature. It covers four databases: Yeastract (S. cerevisiae, about 215,000 associations in 2023), PathoYeastract (Candida glabrata, C. albicans, C. tropicalis, C. parapsilosis, C. auris, and Cryptococcus neoformans), N.C.Yeastract (non-conventional yeasts such as Yarrowia lipolytica, Kluyveromyces lactis, and Komagataella phaffii), and CommunityYeastract, which generates databases for further species and strains from orthology without species-specific curated data. GO annotations come from SGD, the Candida Genome Database, and PomBase.
All data are accessed through the web interfaces, which provide searches for regulators, targets, and associations, DNA motif and promoter analysis, regulation matrices, cross-species comparisons through orthologs, and tools that combine regulatory data with genome-scale metabolic models. The flat-file download page currently lists no files and asks users to contact the team for specific data. The REST web services are no longer maintained.
The YEASTRACT+ Terms of Usage state that there are no restrictions on use or redistribution of the data beyond those set by the original data owners (the authors of the curated articles). Users may not reproduce substantial parts of the content in ways that would compete with YEASTRACT+, and must cite the 2023 YEASTRACT+ publication.
Created: October 10, 2026 | Last modified: October 19, 2026