complexportal

is a Data Source.

The Complex Portal is an encyclopaedic resource of macromolecular complexes from model organisms, providing manually curated and high-confidence machine-learning predicted protein complexes with comprehensive structural and functional annotation.

Domains

proteomics, systems biology

License

CC BY 4.0

Homepage

complexportal

Repository

GitHub

Infores ID

infores:complexportal

FAIRsharing ID

Unknown

Product Summary

Products

From this Resource
ID Name URL Category Format Description
complexportal.portal Complex Portal Web Interface complexportal GraphicalInterface http Web portal for searching, browsing, a...
complexportal.psi25 Complex Portal PSI-MI XML 2.5 psi25 Product psi_mi_xml Complete Complex Portal dataset in PS...
complexportal.psi30 Complex Portal PSI-MI XML 3.0 psi30 Product psi_mi_xml Complete Complex Portal dataset in PS...
complexportal.complextab Complex Portal ComplexTAB complextab Product tsv Complex Portal data in ComplexTAB fla...
complexportal.human.psi25 Complex Portal Human PSI-MI XML 2.5 Homo_sapiens.zip (25.8 MB) Product psi_mi_xml Human complexes dataset from Complex ...
complexportal.human.psi30 Complex Portal Human PSI-MI XML 3.0 human.zip (22.6 MB) Product psi_mi_xml Human complexes dataset from Complex ...
complexportal.human.predicted.psi25 Complex Portal Human Predicted PSI-MI XML 2.5 Homo_sapiens_predicted.zip (145.9 MB) Product psi_mi_xml Human predicted complexes dataset fro...
complexportal.human.predicted.psi30 Complex Portal Human Predicted PSI-MI XML 3.0 human_predicted.zip (114.8 MB) Product psi_mi_xml Human predicted complexes dataset fro...
complexportal.human.complextab Complex Portal Human ComplexTAB 9606.tsv (4.8 MB) Product tsv Human complexes dataset from Complex ...
complexportal.human.predicted.complextab Complex Portal Human Predicted ComplexTAB 9606_predicted.tsv (5.0 MB) Product tsv Human predicted complexes dataset fro...
complexportal.mouse.psi25 Complex Portal Mouse PSI-MI XML 2.5 Mus_musculus.zip (6.0 MB) Product psi_mi_xml Mouse complexes dataset from Complex ...
complexportal.mouse.psi30 Complex Portal Mouse PSI-MI XML 3.0 mouse.zip (5.1 MB) Product psi_mi_xml Mouse complexes dataset from Complex ...
complexportal.mouse.complextab Complex Portal Mouse ComplexTAB 10090.tsv (1.4 MB) Product tsv Mouse complexes dataset from Complex ...
complexportal.yeast.psi25 Complex Portal Yeast PSI-MI XML 2.5 Saccharomyces_cerevisiae.zip (4.4 MB) Product psi_mi_xml Yeast complexes dataset from Complex ...
complexportal.yeast.psi30 Complex Portal Yeast PSI-MI XML 3.0 yeast.zip (3.9 MB) Product psi_mi_xml Yeast complexes dataset from Complex ...
complexportal.yeast.s288c.complextab Complex Portal Yeast S288c ComplexTAB 559292.tsv (871.8 KB) Product tsv Budding yeast (S288c) complexes datas...
complexportal.fruitfly.complextab Complex Portal Fruit Fly ComplexTAB 7227.tsv (323.3 KB) Product tsv Fruit fly complexes dataset from Comp...
complexportal.worm.complextab Complex Portal Worm ComplexTAB 6239.tsv (175.6 KB) Product tsv Worm complexes dataset from Complex P...
complexportal.ecoli.complextab Complex Portal E. coli ComplexTAB 83333.tsv (532.6 KB) Product tsv E. coli complexes dataset from Comple...
complexportal.bsubtilis.complextab Complex Portal Bacillus subtilis ComplexTAB 562.tsv (4.4 KB) Product tsv Bacillus subtilis complexes dataset f...
complexportal.arabidopsis.complextab Complex Portal Arabidopsis thaliana ComplexTAB 3702.tsv (417.0 KB) Product tsv Arabidopsis thaliana complexes datase...
complexportal.lamprey.complextab Complex Portal Lamprey ComplexTAB 6523.tsv (2.6 KB) Product tsv Lamprey complexes dataset from Comple...
complexportal.pufferfish.tetraodon.complextab Complex Portal Pufferfish (Tetraodon) ComplexTAB 7787.tsv (2.7 KB) Product tsv Pufferfish (Tetraodon nigroviridis) c...
complexportal.pufferfish.takifugu.complextab Complex Portal Pufferfish (Takifugu) ComplexTAB 7788.tsv (2.8 KB) Product tsv Pufferfish (Takifugu rubripes) comple...
complexportal.zebrafish.complextab Complex Portal Zebrafish ComplexTAB 7955.tsv (10.5 KB) Product tsv Zebrafish complexes dataset from Comp...
complexportal.xenopus.complextab Complex Portal African Clawed Frog ComplexTAB 8355.tsv (8.9 KB) Product tsv African clawed frog complexes dataset...
complexportal.seaurchin.complextab Complex Portal Sea Urchin ComplexTAB 8732.tsv (24.8 KB) Product tsv Sea urchin complexes dataset from Com...
complexportal.chicken.complextab Complex Portal Chicken ComplexTAB 9031.tsv (58.3 KB) Product tsv Chicken complexes dataset from Comple...
complexportal.dog.complextab Complex Portal Dog ComplexTAB 9615.tsv (5.8 KB) Product tsv Dog complexes dataset from Complex Po...
complexportal.pig.complextab Complex Portal Pig ComplexTAB 9823.tsv (10.9 KB) Product tsv Pig complexes dataset from Complex Po...
complexportal.cattle.complextab Complex Portal Cattle ComplexTAB 9913.tsv (31.9 KB) Product tsv Cattle complexes dataset from Complex...
complexportal.sheep.complextab Complex Portal Sheep ComplexTAB 9940.tsv (1.3 KB) Product tsv Sheep complexes dataset from Complex ...
complexportal.rabbit.complextab Complex Portal Rabbit ComplexTAB 9986.tsv (12.9 KB) Product tsv Rabbit complexes dataset from Complex...
complexportal.rat.complextab Complex Portal Rat ComplexTAB 10116.tsv (261.5 KB) Product tsv Rat complexes dataset from Complex Po...
complexportal.hpylori.complextab Complex Portal Helicobacter pylori ComplexTAB 208964.tsv (2.2 KB) Product tsv Helicobacter pylori complexes dataset...
complexportal.paeru.complextab Complex Portal Pseudomonas aeruginosa ComplexTAB 243277.tsv (2.1 KB) Product tsv Pseudomonas aeruginosa complexes data...
complexportal.fissionyeast.complextab Complex Portal Fission Yeast ComplexTAB 284812.tsv (168.4 KB) Product tsv Fission yeast complexes dataset from ...
complexportal.dictyostelium.complextab Complex Portal Dictyostelium discoideum ComplexTAB 694009.tsv (32.3 KB) Product tsv Dictyostelium discoideum complexes da...
complexportal.leishmania.complextab Complex Portal Leishmania major ComplexTAB 1235996.tsv (9.2 KB) Product tsv Leishmania major complexes dataset fr...
complexportal.toxoplasma.complextab Complex Portal Toxoplasma gondii ComplexTAB 1263720.tsv (24.4 KB) Product tsv Toxoplasma gondii complexes dataset f...
complexportal.sarscov2.complextab Complex Portal SARS-CoV-2 ComplexTAB 2697049.tsv (71.4 KB) Product tsv SARS-CoV-2 complexes dataset from Com...
complexportal.released-complexes Complex Portal Released Complexes released_complexes.txt (259.5 KB) Product txt Tab-delimited list of complexes relea...
complexportal.db-crossrefs Complex Portal Database Cross-References complex_portal_dr_export.tsv (1.2 MB) MappingProduct tsv Cross-references exported from Comple...
complexportal.id-translation Complex Portal ID Translation Table cpx_ebi_ac_translation.txt (68.3 KB) MappingProduct txt Translation table between stable Comp...
complexportal.webservice Complex Portal Web Service webservice ProgrammingInterface http RESTful web service API for programma...
complexportal.documentation Complex Portal Documentation documentation DocumentationProduct http Comprehensive documentation covering ...
From other Resources
ID Name URL Category Format Description
mechreponet.kg MechRepoNet Knowledge Graph publication The MechRepoNet knowledge graph in it...
obo-db-ingest.complexportal.tsv complexportal Nodes TSV complexportal.tsv (638.9 KB) Product tsv complexportal Nodes TSV

Details

Complex Portal

Overview

The Complex Portal is a comprehensive, manually curated resource of macromolecular complexes from key model organisms. It serves as an authoritative aggregator that combines expert manual curation with high-confidence machine-learning predictions to provide detailed annotations for protein complexes that have been experimentally characterized.

Data Content

The Complex Portal defines complexes as assemblies of two or more proteins and/or nucleic acids that are stable enough to be reconstituted in vitro and have demonstrated specific molecular functions. The resource covers multiple organisms:

  • Human (Homo sapiens) - Most comprehensive coverage
  • Mouse (Mus musculus) - Key model organism
  • Yeast (Saccharomyces cerevisiae) - Well-studied unicellular model
  • Fruit fly (Drosophila melanogaster) - Developmental biology model
  • Worm (Caenorhabditis elegans) - Simple multicellular model
  • E. coli (Escherichia coli) - Bacterial model

Complex Annotation Features

Each complex entry provides:

  • Protein composition with UniProt identifiers and stoichiometry
  • Functional annotation using Gene Ontology terms
  • Cellular localization and tissue distribution
  • Structural information and cross-references to PDB
  • Disease associations and clinical relevance
  • Experimental evidence with literature references
  • Complex assembly pathways and regulatory mechanisms

High-Confidence Predictions

In addition to manually curated complexes, the portal includes:

  • hu.MAP 3.0 predictions - Machine learning-derived human protein complexes
  • MuSIC predictions - Multi-species interaction complexes
  • Quality scores and confidence metrics for computational predictions

Data Formats and Access

File Formats

  1. PSI-MI XML 2.5/3.0 - Proteomics Standards Initiative format with comprehensive metadata
  2. ComplexTAB - Flat-file format designed for easy parsing and Excel compatibility
  3. Web Service API - RESTful interface for programmatic access

Data Organization

Data is systematically organized by:

  • Species-specific files for targeted organism studies
  • Complete datasets for comprehensive analyses
  • Monthly releases with version control and change logs
  • FTP access for bulk downloads and automated processing

Applications

Research Applications

  • Systems biology modeling of cellular networks
  • Drug discovery targeting specific protein complexes
  • Structural biology studies of macromolecular assemblies
  • Proteomics analysis of complex compositions
  • Disease research investigating complex dysfunction

Integration Partners

The Complex Portal integrates with and contributes to:

  • IntAct molecular interaction database
  • UniProt protein sequence and annotation
  • PDBe structural biology database
  • Gene Ontology functional annotation
  • Reactome pathway database

Quality Assurance

Curation Standards

  • Manual curation from peer-reviewed literature
  • Expert biocurator review and validation
  • Cross-referencing with multiple evidence sources
  • Regular updates incorporating new experimental data
  • Community feedback and correction mechanisms

Data Reliability

  • Experimental evidence requirements for all entries
  • Confidence scoring for computational predictions
  • Version tracking and change documentation
  • Quality metrics and validation procedures

Citations and Usage

The Complex Portal is freely available under CC BY 4.0 license. Users should cite both the database and specific datasets used. The resource serves as a Global Core Biodata Resource and is part of the ELIXIR infrastructure for biological data management.

Is this information incorrect or incomplete? Request an update.

Created: July 17, 2025 | Last modified: February 26, 2026