sldb

is a Knowledge Graph.

A graph of synthetic lethal interactions.

Domains

biomedical, genomics

License

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Homepage

sldb

Repository

GitHub

Infores ID

Unknown

FAIRsharing ID

Unknown

Product Summary

Contacts

Peter Robinson

Github: pnrobinson

Products

From this Resource
ID Name URL Category Format Description
sldb.code SLDB Source Repository SLDBGen ProcessProduct http Source code for building the syntheti...
sldb.docs SLDB Documentation SLDBGen#readme DocumentationProduct http Project README and documentation for ...
sldb.data SLDB Interaction Table SL_data.tsv (35.5 KB) Product tsv Tab-separated export of curated synth...
sldb.releases SLDB Releases releases Product mixed Release artifacts for SLDB graph builds.

Details

SLDB is a synthetic lethality knowledge graph and build workflow developed in the Monarch Initiative ecosystem. The project curates synthetic lethal relationships from published cancer studies, normalizes gene identifiers, captures assay and perturbation context, and emits a structured interaction table that can be reused for downstream graph construction.

The upstream SLDBGen repository includes the extraction scripts, test data, and a tabular export of curated interactions. Records in the published table include the paired genes, identifier mappings, perturbation types, assay information, cell line context, and PMID-backed provenance from the source literature.

Automated Evaluation

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Created: March 09, 2025 | Last modified: July 01, 2026